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Ben Kleinstiver
bkleinstiver.bsky.social
did:plc:2mwjjup73vbml7tlixtf4c5r
Optimization of a bespoke base editor to treat a severe pediatric vascular disease! 🫀🧬
Our manuscript describes:
1️⃣ Engineering a target-specific BE🧬
2⃣ A *must avoid* bystander edit that occurs with WT SpCas9 BEs! 🙅♂️
3⃣ Extension of lifespan after in vivo editing! 🐁✅
https://www.nature.com/articles/s41551-025-01499-1
2025-09-12T02:00:52.810Z