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Rémi Buisson
buissonlab.bsky.social
did:plc:nv46f5vleyk2omwxe663mgqj
Today, we report that APOBEC3B targets unprotected single-stranded DNA at replication forks upon ATR inhibition, triggering a reaction cascade involving UNG2 and APE1 that leads to fork collapse and hyperactivation of PARP1, causing replication catastrophe.
https://www.science.org/doi/10.1126/sciadv.adu0437
2025-04-16T21:19:42.886Z