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Roberto Chica Lab
chicalab.bsky.social
did:plc:ewcrd3pyisorjeiinh2n3x6t
In collaboration with @birtehoecker.bsky.social, we’ve unlocked enzymatic activity in a minimal de novo TIM barrel by designing a custom lid for catalysis! 🧵👇
#ProteinDesign #EnzymeDesign
Customizing the Structure of a Minimal TIM Barrel to Create a De Novo Enzyme
https://www.biorxiv.org/content/10.1101/2025.01.28.635154v2
2025-07-29T18:33:16.504Z