🦠🚀 High-impact infectious disease research—Rigorous in review, Global in impact. Gold open access and indexed in PubMed, Scopus, and ESCI.https://bsky.app/profile/tainfdis.bsky.socialhttps://bsky.app/profile/tainfdis.bsky.social/post/3mlbugbmzhc27New systematic review & meta-analysis in SSA HCWs shows moderate AMR knowledge (65%) and attitudes (69%), but weaker practices (54%), with a clear knowledge–practice gap—most evident among doctors (knowledge 65%, practice 43%). https://journals.sagepub.com/doi/full/10.1177/2049936125141067707 May 2026 18:39 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mlbugbmzhc27https://bsky.app/profile/tainfdis.bsky.social/post/3mksdk4uzy224TB treatment is evolving—but persistence remains a major barrier. New evidence shows macrophage metabolism and redox state shape intracellular drug tolerance in Mtb. Host-directed strategies may enhance antibiotic efficacy and help shorten therapy ⏳ https://journals.sagepub.com/doi/full/10.1177/2049936126144529501 May 2026 14:27 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mksdk4uzy224https://bsky.app/profile/tainfdis.bsky.social/post/3mki7illoek2rCase report: a young patient with years of “chronic lung disease” ultimately diagnosed with aggressive HTLV-1 driven lymphoma-fatal within weeks. Early biopsy + T-cell panel (CD4+CD25+ with CD7 loss) should trigger HTLV-1 testing, regardless of geography. https://journals.sagepub.com/doi/full/10.1177/2049936126144413627 Apr 2026 13:48 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mki7illoek2rhttps://bsky.app/profile/tainfdis.bsky.social/post/3mki7fnfyuk2rCKD and UTIs form a vicious cycle: kidney dysfunction increases infection risk ; while recurrent UTIs accelerate renal decline. Breaking this loop demands early CKD detection, antimicrobial stewardship & non-antibiotic prevention strategies. https://journals.sagepub.com/doi/full/10.1177/2049936126144105627 Apr 2026 13:46 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mki7fnfyuk2rhttps://bsky.app/profile/tainfdis.bsky.social/post/3mk3mnzzya224Neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) are valuable, readily available markers for gauging severity in community-acquired pneumonia 🦠📊 https://journals.sagepub.com/doi/10.1177/2049936126144170322 Apr 2026 13:39 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mk3mnzzya224https://bsky.app/profile/tainfdis.bsky.social/post/3mk3mdm2ag22uCKD and UTIs form a dangerous feedback loop 🔁: impaired immunity and structural changes drive recurrent, often MDR infections, which in turn hasten kidney decline. Prevention, early detection, and stewardship are central to breaking the cycle https://journals.sagepub.com/doi/full/10.1177/2049936126144105622 Apr 2026 13:33 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mk3mdm2ag22uhttps://bsky.app/profile/tainfdis.bsky.social/post/3mjumdhobic26Prospective study (Ukraine/Moldova/Spain, n=287): mfloDx™ MDR-TB assay achieved Se 100% / Sp 98.7% for INH+RIF resistance vs culture DST. Caveat: 35% inconclusive results. Potential role as rapid screening tool. https://journals.sagepub.com/doi/full/10.1177/2049936126143654219 Apr 2026 18:44 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mjumdhobic26https://bsky.app/profile/tainfdis.bsky.social/post/3mjeubgtcec2oDoes EV-D68 amplify TB immunopathology? Case series suggests coinfection may worsen lung inflammation, with clinical response seen after corticosteroid escalation. A reminder to consider viral triggers in atypical TB courses. https://journals.sagepub.com/doi/10.1177/2049936126143291813 Apr 2026 12:24 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mjeubgtcec2ohttps://bsky.app/profile/tainfdis.bsky.social/post/3mipxkl3i5c2bArboviruses don’t act in isolation 🦟 Chikungunya and Zika spread where structural vulnerabilities persist—limited surveillance, inequity, and inadequate sanitation. Future resilience depends on integrating social and biological surveillance systems 🧬. https://journals.sagepub.com/doi/10.1177/2049936126143824005 Apr 2026 04:56 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mipxkl3i5c2bhttps://bsky.app/profile/tainfdis.bsky.social/post/3mipxfjd6k227Diagnosing invasive mold infections 🧫 in immunocompromised patients remains difficult.NGS 🧬 offers noninvasive, actionable insights-identifying missed infections and guiding therapy in over half of cases. https://journals.sagepub.com/doi/10.1177/2049936126143700905 Apr 2026 04:54 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mipxfjd6k227https://bsky.app/profile/tainfdis.bsky.social/post/3mipxatclfk27Malaria 🦟 + soil-transmitted helminths 🪱 often co-infect young children in Nigeria, driving early red cell changes 🩸 before overt anaemia. Host factors esp haemoglobin genotype 🧬matter more than parasite load. https://journals.sagepub.com/doi/10.1177/2049936126142577405 Apr 2026 04:51 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mipxatclfk27https://bsky.app/profile/tainfdis.bsky.social/post/3mi52lhkxnc2cNew meta-analysis 📊: HBV escape mutations are common in LMICs 🧬 Immune escape ~56% 💊 Resistance highest with 3TC/LdT https://journals.sagepub.com/doi/full/10.1177/2049936126143160628 Mar 2026 16:30 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mi52lhkxnc2chttps://bsky.app/profile/tainfdis.bsky.social/post/3mhlepq3sqs2eCase report: in HIV patient with recurrent Cryptocccal meningitis 🧠 despite virologic suppression, re-induction + isavuconazole led to immune recovery, viral control, and no further CM episodes over 6 months https://journals.sagepub.com/doi/full/10.1177/2049936125139590321 Mar 2026 15:43 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mhlepq3sqs2ehttps://bsky.app/profile/tainfdis.bsky.social/post/3mhiwsmwbpc2oChronic pulmonary aspergillosis + pulmonary embolism = a challenging duo 🫁🦠🩸Mechanisms may include inflammation + endothelial damage 🧬Management is tricky—anticoagulation vs hemoptysis risk ⚖️https://journals.sagepub.com/doi/full/10.1177/2049936126143190020 Mar 2026 16:29 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mhiwsmwbpc2ohttps://bsky.app/profile/tainfdis.bsky.social/post/3mh6jk674fs2mP: Mild COVID-19 pneumonia 🦠 I: Clarithromycin 800 mg/day 💊 C: Standard of care O: No significant change in time to 50% symptom improvement, but ↓ fatigue and ↓ inflammatory cytokines. Signals of immunomodulation worth further study. 🔬 https://journals.sagepub.com/doi/full/10.1177/2049936126143148816 Mar 2026 13:05 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mh6jk674fs2mhttps://bsky.app/profile/tainfdis.bsky.social/post/3mh6jh5dxkk2mContingency management isn’t just for abstinence.A harm-reduction clinic for people who use drugs used incentives to encourage risk assessment, testing, clinic engagement to reduce HIV and infection risk.Early results show engagement among patients. https://journals.sagepub.com/doi/full/10.1177/2049936126142091616 Mar 2026 13:04 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mh6jh5dxkk2mhttps://bsky.app/profile/tainfdis.bsky.social/post/3mgzkp3mugk2pIn a survey of women in 🇿🇦 younger women& those engaged in transactional sex were more likely to intend to use PrEP, while condom users were less likely. #HIVPrevention #PrEP https://journals.sagepub.com/doi/full/10.1177/2049936125139976514 Mar 2026 13:43 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mgzkp3mugk2phttps://bsky.app/profile/tainfdis.bsky.social/post/3mfepnsjb722uStrongyloides hyperinfection can occur without eosinophilia—even with CD4 >500 and undetectable HIV viral load. Early diagnosis is lifesaving ⚠️ https://journals.sagepub.com/doi/full/10.1177/2049936126142532721 Feb 2026 13:20 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mfepnsjb722uhttps://bsky.app/profile/tainfdis.bsky.social/post/3met77oixa223Invasive pulmonary aspergillosis remains a lethal threat in immunocompromised and post-COVID patients 🦠 Advances in PCR, lateral flow assays, and immuno-PET/MRI are reshaping diagnosis, but rising azole resistance demands susceptibility testing https://journals.sagepub.com/doi/full/10.1177/2049936125140618914 Feb 2026 14:11 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3met77oixa223https://bsky.app/profile/tainfdis.bsky.social/post/3meobv34y2k2fIn this systematic review (29 studies), mNGS outperformed culture for spinal infections with broader pathogen detection,higher sensitivity,faster turnaround⏱️ Challenges remain: cost & distinguishing colonization from infection. https://journals.sagepub.com/doi/full/10.1177/2049936125141278912 Feb 2026 15:15 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3meobv34y2k2fhttps://bsky.app/profile/tainfdis.bsky.social/post/3mduwkqj6m22zPeptide-based vaccines are redefining precision immunology, offering safety, specificity,scalable manufacturing. This review explores how bioinformatics-driven epitope design, nanoparticles,& next-gen adjuvants are fighting viral threats 🚀🦠 https://journals.sagepub.com/doi/full/10.1177/2049936125141118802 Feb 2026 13:16 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mduwkqj6m22zhttps://bsky.app/profile/tainfdis.bsky.social/post/3mdavjpoqjk2vTicks strike twice 🐜🐜 Fatal Babesia microti/Borrelia burgdorferi coinfection presenting as acute liver failure and shock. Read full case @ https://journals.sagepub.com/doi/full/10.1177/2049936126141619025 Jan 2026 14:04 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mdavjpoqjk2vhttps://bsky.app/profile/tainfdis.bsky.social/post/3mcf3ss3znc2a🦠 Rare but severe: necrotizing gingival & sinus infection due to Trichoderma longibrachiatum in an allo-HSCT recipient. Cure achieved with aggressive surgery 🔪 + combination antifungals 💊, including consolidation with rezafungin. https://journals.sagepub.com/doi/full/10.1177/2049936125140306014 Jan 2026 12:42 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mcf3ss3znc2ahttps://bsky.app/profile/tainfdis.bsky.social/post/3mccqxoqvkk22Febrile neutropenia still drives heavy carbapenem use due to MDR Gram-negatives. In a cohort of 553 FN episodes, an ML risk model + prior colonisation data could cut meropenem use by ~30% and IEAT from 23% to 9%, supporting personalised EAT. https://journals.sagepub.com/doi/full/10.1177/2049936125141106113 Jan 2026 14:23 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mccqxoqvkk22https://bsky.app/profile/tainfdis.bsky.social/post/3mb7jexyw3222Chronic pulmonary aspergillosis can complicate pulmonary echinococcosis via residual lung cavities. In this review (41 studies, 72 CPA cases), diagnosis relied on radiology/histology, combined surgical–medical therapy led to uniformly favorable outcomes https://journals.sagepub.com/doi/full/10.1177/2049936125140436230 Dec 2025 14:04 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mb7jexyw3222https://bsky.app/profile/tainfdis.bsky.social/post/3mathbwwcys2e⚠️ Rising MDR in cUTIs demands new options. Plazomicin shows strong in-vitro activity, synergy with key agents, and favorable outcomes in trials—yet real-world evidence from LMICs is urgently needed 📉📊. https://journals.sagepub.com/doi/full/10.1177/2049936125140110425 Dec 2025 18:54 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mathbwwcys2ehttps://bsky.app/profile/tainfdis.bsky.social/post/3maqmp2wezc2rImidazolopiperazines (KAF156/ganaplacide) show potent activity across blood, liver, and gametocyte stages of Plasmodium 🦟💊—a promising path forward as antimalarial resistance rises. https://journals.sagepub.com/doi/full/10.1177/2049936125140177124 Dec 2025 15:53 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3maqmp2wezc2rhttps://bsky.app/profile/tainfdis.bsky.social/post/3mae7a53y6c2q🧬 Unusual infection: M. luteus, normally a skin commensal, triggered prosthetic valve endocarditis in an immunocompetent woman. 8 weeks of IV vancomycin led to full recovery. https://journals.sagepub.com/doi/full/10.1177/2049936125140305419 Dec 2025 17:20 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mae7a53y6c2qhttps://bsky.app/profile/tainfdis.bsky.social/post/3mae75mg33c2q📊 New study from Teso, Uganda: Among 1009 TB patients, overall treatment success was 91.9%. Females had higher success, while age >49 and HIV infection lowered success. Early screening, preventive therapy, and peer support are key to improving outcomes. https://journals.sagepub.com/doi/full/10.1177/2049936125140533419 Dec 2025 17:19 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3mae75mg33c2qhttps://bsky.app/profile/tainfdis.bsky.social/post/3m7psexb6kc2hAntipseudomonal beta lactams yielded outcomes similar to cefazolin/oxacillin in this study of of MSSA bacteremia.However there were more complicated infections in the SOC arm.These data may inform antibiotic choices when broad coverage is needed. https://journals.sagepub.com/doi/full/10.1177/2049936125139552711 Dec 2025 14:37 +0000at://did:plc:2agtlh32fgdql3aw2np2yng3/app.bsky.feed.post/3m7psexb6kc2h