I am a population geneticist.https://bsky.app/profile/davecutler.bsky.socialhttps://bsky.app/profile/davecutler.bsky.social/post/3l2655cnkta2nDid you ever wonder how good any disease predictor based only on genetic data could be? Answer: it is a function of the heritability of the markers used, and might not be very high, without ~all~ the genetic variants identified. Figure 5. https://www.pivotscipub.com/hpgg/4/3/0008/html20 Aug 2024 17:30 +0000at://did:plc:2slhi4celibxhfcom3we2uoi/app.bsky.feed.post/3l2655cnkta2nhttps://bsky.app/profile/davecutler.bsky.social/post/3l265357ww72qDid you ever wonder why polygenic risk scores seem so hard to interpret across populations? Answer: it is almost all due to allele frequency and LD differences. https://www.pivotscipub.com/hpgg/4/3/0008/html20 Aug 2024 17:28 +0000at://did:plc:2slhi4celibxhfcom3we2uoi/app.bsky.feed.post/3l265357ww72qhttps://bsky.app/profile/davecutler.bsky.social/post/3kg2kljugee2yThis monster of paper is entirely open source, so if you find it at all useful, please share it with your friends and trainees.  https://pivotscipub.com/hpgg/3/4/0007/html08 Dec 2023 18:56 +0000at://did:plc:2slhi4celibxhfcom3we2uoi/app.bsky.feed.post/3kg2kljugee2yhttps://bsky.app/profile/davecutler.bsky.social/post/3kg2kb3woyu2wDo you know what an additive by additive genetic interaction is? If you want to see a definition and a description for how to calculate such a thing for both quantitative and binary traits try  https://pivotscipub.com/hpgg/3/4/0007/html08 Dec 2023 18:50 +0000at://did:plc:2slhi4celibxhfcom3we2uoi/app.bsky.feed.post/3kg2kb3woyu2whttps://bsky.app/profile/davecutler.bsky.social/post/3kg2k4y6c732kHave you ever wanted to know how to calculate heritability for a human disease? Have you ever wanted to know how to convert human genetics quantities like odds ratios or penetrance into their quantitative genetics equivalents?  https://pivotscipub.com/hpgg/3/4/0007/html08 Dec 2023 18:47 +0000at://did:plc:2slhi4celibxhfcom3we2uoi/app.bsky.feed.post/3kg2k4y6c732khttps://bsky.app/profile/davecutler.bsky.social/post/3kg2jzcy6cf23Have you ever wanted to see a derivation of fundamental quantitative genetics results without any assumption of normal distributions?  https://pivotscipub.com/hpgg/3/4/0007/html08 Dec 2023 18:45 +0000at://did:plc:2slhi4celibxhfcom3we2uoi/app.bsky.feed.post/3kg2jzcy6cf23