Neuroscientist, Professor at University Hospital Cologne, @unicologne.bsky.social My lab studies molecular and circuit mechanisms of neurodegeneration.https://bsky.app/profile/irinadudanova.bsky.socialhttps://bsky.app/profile/irinadudanova.bsky.social/post/3mpm7mh26222yOur joint study with Takaki Komiyama @takakikomiyama.bsky.social is out in @nature.com! We found cell type-specific changes in the cortical circuit of Huntington’s disease mice. Optogenetic stimulation of VIP interneurons rescued circuit dysfunction and improved motor behavior. https://www.nature.com/articles/s41586-026-10671-9?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20260701&utm_content=10.1038/s41586-026-10671-901 Jul 2026 19:06 +0000at://did:plc:3bcaavr2b5wktlb2cftkcasv/app.bsky.feed.post/3mpm7mh26222yhttps://bsky.app/profile/irinadudanova.bsky.social/post/3mp76twq35s2lOur paper on the effects of anle138b in #Huntington’sDisease models is now out in @embomolmed.org. Many thanks to everyone who has made this possible, especially Miguel da Silva Padilha and all our collaborators, including @sedakoyuncu.bsky.social @thevilchezlab.bsky.social. https://link.springer.com/article/10.1038/s44321-026-00459-926 Jun 2026 14:48 +0000at://did:plc:3bcaavr2b5wktlb2cftkcasv/app.bsky.feed.post/3mp76twq35s2lhttps://bsky.app/profile/irinadudanova.bsky.social/post/3mimitdghv22mI am starting a new chapter as Full Professor and Chair of Anatomy and Cell Biology at the University of Würzburg. I am deeply grateful to all my wonderful colleagues in Cologne with whom I've had the pleasure of working together. I will miss the great environment of the Uniklinik campus.03 Apr 2026 19:55 +0000at://did:plc:3bcaavr2b5wktlb2cftkcasv/app.bsky.feed.post/3mimitdghv22mhttps://bsky.app/profile/irinadudanova.bsky.social/post/3m6yy3q7o5k2zNew preprint from the lab by Dennis Feigenbutz et al.: Using #snRNA-seq, we explore vulnerability profiles of cortical cell types in #HuntingtonsDisease mice and identify ER-phagy as a new pathway in HD pathogenesis. https://www.biorxiv.org/content/10.1101/2025.11.28.691138v102 Dec 2025 12:48 +0000at://did:plc:3bcaavr2b5wktlb2cftkcasv/app.bsky.feed.post/3m6yy3q7o5k2zhttps://bsky.app/profile/irinadudanova.bsky.social/post/3lymmf2bh3s2wCongratulations to Cole Sitron et al. from Ulrich Hartl's group @mpibiochem.bsky.social on this beautiful study exploring the interaction of α-synuclein aggregates with the ESCRT-III complex, now out in @cp-molcell.bsky.social - it was a pleasure to contribute to the project. [contains quote post or other embedded content]12 Sep 2025 06:15 +0000at://did:plc:3bcaavr2b5wktlb2cftkcasv/app.bsky.feed.post/3lymmf2bh3s2whttps://bsky.app/profile/irinadudanova.bsky.social/post/3llou7ugy7s27Delighted to be part of the new Research Unit on Organismal Proteostasis. Thanks to @thevilchezlab.bsky.social for all the hard work on putting together this consortium, and to the #DFG for funding our research! [contains quote post or other embedded content]31 Mar 2025 17:13 +0000at://did:plc:3bcaavr2b5wktlb2cftkcasv/app.bsky.feed.post/3llou7ugy7s27https://bsky.app/profile/irinadudanova.bsky.social/post/3lkd5snftp226Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment. Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social [contains quote post or other embedded content]14 Mar 2025 08:08 +0000at://did:plc:3bcaavr2b5wktlb2cftkcasv/app.bsky.feed.post/3lkd5snftp226https://bsky.app/profile/irinadudanova.bsky.social/post/3lhqoxqmq2k2oHow do different cortical neuron types contribute to circuit dysfunction in #Huntington’s disease? Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint. https://www.biorxiv.org/content/10.1101/2025.02.07.637155v109 Feb 2025 13:04 +0000at://did:plc:3bcaavr2b5wktlb2cftkcasv/app.bsky.feed.post/3lhqoxqmq2k2o