Light microscopy at Bruker Fluorescence Microscopy division. #lightsheet #multiphoton #superresolution #screening Cell biologist in my previous life. Alumnus @mpicbg.bsky.social @turkubioscience.bsky.social‬https://bsky.app/profile/ichajaroslav.bsky.socialhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mz3o7heex22jTetraspanin-labeled extracellular vesicles from a recent demo of Bruker superresolution microscope Vutara VXL. The individual EV size is in 10s of nm. See what we can do in EV imaging including capturing EVs in tissues, automated EV analysis and quantitative reports: https://www.bruker.com/en/products-and-solutions/fluorescence-microscopy/super-resolution-microscopes/extracellular-vesicle-ev-visualization-and-quantification.html30 Oct 2026 11:24 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mz3o7heex22jhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mz3o7heex22jTetraspanin-labeled extracellular vesicles from a recent demo of Bruker superresolution microscope Vutara VXL. The individual EV size is in 10s of nm. See what we can do in EV imaging including capturing EVs in tissues, automated EV analysis and quantitative reports: https://www.bruker.com/en/products-and-solutions/fluorescence-microscopy/super-resolution-microscopes/extracellular-vesicle-ev-visualization-and-quantification.html30 Oct 2026 11:24 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mz3o7heex22jhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3myzex4sg4c2cDo laser ablation experiments have to be slow and done one sample at a time? You know the answer is NO! 😊 New publication from Nadia Mercader Huber lab shows how to scale laser ablation into 96-well plate format with the power of Bruker Luxendo Acquifer IM equipped with a photomanipulation module.29 Oct 2026 13:33 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3myzex4sg4c2chttps://bsky.app/profile/ichajaroslav.bsky.social/post/3myzex4sg4c2cDo laser ablation experiments have to be slow and done one sample at a time? You know the answer is NO! 😊 New publication from Nadia Mercader Huber lab shows how to scale laser ablation into 96-well plate format with the power of Bruker Luxendo Acquifer IM equipped with a photomanipulation module.29 Oct 2026 13:33 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3myzex4sg4c2chttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mqebhyqwh22nI'm sitting in the last session of the #EZM2026 conference and I'm grateful that I could participate on behalf of @brukercorporation.bsky.social Fluorescence Microscopy. Great trip to my academic past, I was relieved that I still more or less understand what people are working on.11 Jul 2026 08:44 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mqebhyqwh22nhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mrli7cu4yk2qThis week I visited Belgium for a Bruker Luxendo HIVE server installation (Fig. 1) with a detour to the Netherlands for some Bruker Fluorescence Microscopy lightsheet and superresolution microscopy conversations.26 Jul 2026 22:58 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mrli7cu4yk2qhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mxqrn6c2a22kI enjoyed reading this paper from Wittbrodt lab on retinal lamination, using in vitro approach of retinal organoids/assembloids. It adds to what we know about need for polarity cues in the developing retina and draws a parallel to invertebrate compound eye development. https://www.cell.com/iscience/fulltext/S2589-0042(26)01059-X13 Oct 2026 10:01 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mxqrn6c2a22khttps://bsky.app/profile/ichajaroslav.bsky.social/post/3my7paumxvs2nNew paper in eLife showing lens morphogenesis taking a very different route in medaka organoids as opposed to in vivo in the fish embryo. Wittbrodt and Zilova from COS Heidelberg as senior authors. Video: First stage of lens formation in medaka retinal organoids. Lens precursors expressing GFP.19 Oct 2026 08:28 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3my7paumxvs2nhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3myetimuoyk2qToday I want to highlight other typical lightsheet microscopy use – in toto embryo imaging with laser ablation. In a recent Biophysical J paper Timo Betz and co. from Uni of Göttingen studied how robust zebrafish gastrulation is to mechanical perturbation by laser ablation. Tl;DR: very robust.21 Oct 2026 09:28 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3myetimuoyk2qhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mycfdh67l225Today I want to highlight a study from Elvan Böke lab at CRG in Barcelona as a perfect example why it makes sense to use tissue clearing and lightsheet microscopy.20 Oct 2026 10:09 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mycfdh67l225https://bsky.app/profile/ichajaroslav.bsky.social/post/3mxzns4n6nk2hI'm happy to share that we installed the superresolution microscope Vutara VXL (by Bruker Fluorescence Microscopy), including the fluidics unit at the Hubrecht Institute. I'm sure we will see great science coming out of this system.16 Oct 2026 22:46 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mxzns4n6nk2hhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3myetimuoyk2qToday I want to highlight other typical lightsheet microscopy use – in toto embryo imaging with laser ablation. In a recent Biophysical J paper Timo Betz and co. from Uni of Göttingen studied how robust zebrafish gastrulation is to mechanical perturbation by laser ablation. Tl;DR: very robust.21 Oct 2026 09:28 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3myetimuoyk2qhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mycfdh67l225Today I want to highlight a study from Elvan Böke lab at CRG in Barcelona as a perfect example why it makes sense to use tissue clearing and lightsheet microscopy.20 Oct 2026 10:09 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mycfdh67l225https://bsky.app/profile/ichajaroslav.bsky.social/post/3my7paumxvs2nNew paper in eLife showing lens morphogenesis taking a very different route in medaka organoids as opposed to in vivo in the fish embryo. Wittbrodt and Zilova from COS Heidelberg as senior authors. Video: First stage of lens formation in medaka retinal organoids. Lens precursors expressing GFP.19 Oct 2026 08:28 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3my7paumxvs2nhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mxzns4n6nk2hI'm happy to share that we installed the superresolution microscope Vutara VXL (by Bruker Fluorescence Microscopy), including the fluidics unit at the Hubrecht Institute. I'm sure we will see great science coming out of this system.16 Oct 2026 22:46 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mxzns4n6nk2hhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mxqrn6c2a22kI enjoyed reading this paper from Wittbrodt lab on retinal lamination, using in vitro approach of retinal organoids/assembloids. It adds to what we know about need for polarity cues in the developing retina and draws a parallel to invertebrate compound eye development. https://www.cell.com/iscience/fulltext/S2589-0042(26)01059-X13 Oct 2026 10:01 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mxqrn6c2a22khttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mrli7cu4yk2qThis week I visited Belgium for a Bruker Luxendo HIVE server installation (Fig. 1) with a detour to the Netherlands for some Bruker Fluorescence Microscopy lightsheet and superresolution microscopy conversations.26 Jul 2026 22:58 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mrli7cu4yk2qhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mqebhyqwh22nI'm sitting in the last session of the #EZM2026 conference and I'm grateful that I could participate on behalf of @brukercorporation.bsky.social Fluorescence Microscopy. Great trip to my academic past, I was relieved that I still more or less understand what people are working on.11 Jul 2026 08:44 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mqebhyqwh22nhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mpxqkeu3o22bCome to the Bruker Fluorescence Microscopy booth at the #EZM2026 zebrafish meeting in Vienna this week to learn how to capture movies like this one below in high throughput.06 Jul 2026 09:09 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mpxqkeu3o22bhttps://bsky.app/profile/ichajaroslav.bsky.social/post/3mpxqkeu3o22bCome to the Bruker Fluorescence Microscopy booth at the #EZM2026 zebrafish meeting in Vienna this week to learn how to capture movies like this one below in high throughput.06 Jul 2026 09:09 +0000at://did:plc:3o7tc7lt3resqlppzwxnf6pd/app.bsky.feed.post/3mpxqkeu3o22b