Catch the latest updates on aversive learning & memory, anxiety, fear, stress, and effects of psychedelics and cannabinoids from our rodent lab in Florianopolis, Brazil, and others!https://bsky.app/profile/bertogliolab.bsky.socialhttps://bsky.app/profile/bertogliolab.bsky.social/post/3mvs6vyf6u22cTopographic structure and function of locus coeruleus noradrenaline neurons https://www.nature.com/articles/s41586-026-11026-018 Sep 2026 12:41 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs6vyf6u22chttps://bsky.app/profile/bertogliolab.bsky.social/post/3mvs5j3togs23Reconciling the neurogenic hypothesis of depression with recent advances in adult hippocampal neurogenesis research in humans https://www.nature.com/articles/s41380-026-03896-718 Sep 2026 12:16 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs5j3togs23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvs5fdciqs23Toward autonomous science with agentic artificial intelligence https://www.cell.com/cell/abstract/S0092-8674(26)01063-918 Sep 2026 12:14 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs5fdciqs23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvs5ce6kis23A hypothalamic circuit links high-fat diet exposure to anxiety-like behavior and anxiety-associated hyperphagia https://www.nature.com/articles/s41467-026-77749-w18 Sep 2026 12:12 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs5ce6kis23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvs542agg223Reciprocal connections dynamically build consensus between neocortical areas https://www.nature.com/articles/s41593-026-02437-318 Sep 2026 12:09 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs542agg223https://bsky.app/profile/bertogliolab.bsky.social/post/3mvs4pqhkus23The Amygdalostriatal Transition Area Exhibits Lateral Amygdala–Like Spiking Activity and Tone–Shock Pairing–Induced Plasticity https://www.jneurosci.org/content/early/2026/09/16/JNEUROSCI.2285-25.202618 Sep 2026 12:02 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs4pqhkus23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvs4am3kus23Stress and Cancer from an Integrative Psychoneuroimmunology Perspective: Neurobiological Mechanisms and Clinical Implications https://www.sciencedirect.com/science/article/pii/S014976342600440918 Sep 2026 11:53 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs4am3kus23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvs45d3pas23Relational memory structure among prior neutral episodes guides Pavlovian threat responses https://learnmem.cshlp.org/content/33/8-9/a054210.abstract18 Sep 2026 11:51 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs45d3pas23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvs3z35uw223Baseline cortisol level moderated the effect of stress on associative memory: Pre-encoding and pre-retrieval manipulations https://www.sciencedirect.com/science/article/pii/S107474272600090018 Sep 2026 11:49 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs3z35uw223https://bsky.app/profile/bertogliolab.bsky.social/post/3mvs3jsnres23Mechanistic Basis for 5-HT2AR Over 5-HT2BR Activation https://doi.org/10.1038/s41467-026-77659-x18 Sep 2026 11:40 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs3jsnres23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvs3isemtc23Structure-based design of subtype-selective psychedelic analogs https://doi.org/10.1038/s41467-026-77658-y18 Sep 2026 11:40 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvs3isemtc23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvphzunawc27Developmental xenocortication using human-derived organoids in mice https://www.nature.com/articles/s41586-026-11032-217 Sep 2026 10:46 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvphzunawc27https://bsky.app/profile/bertogliolab.bsky.social/post/3mvphsfhups27Brain-wide reconfiguration of burst firing by psilocybin reveals 5-HT2A-dependent circuit dynamics https://www.biorxiv.org/content/10.64898/2026.08.14.744865v217 Sep 2026 10:42 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvphsfhups27https://bsky.app/profile/bertogliolab.bsky.social/post/3mvphpvy6bs27Acute LSD induces a time-dependent shift toward hippocampal control of default mode network reorganization https://www.biorxiv.org/content/10.64898/2026.09.03.748807v117 Sep 2026 10:41 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvphpvy6bs27https://bsky.app/profile/bertogliolab.bsky.social/post/3mvphcbh6hs27Ligand-specific effects of 5-HT2A receptor antagonists on fear extinction in C57BL/6J mice: Comparative insights from MDL 11,939 and MDL 100,907 https://www.biorxiv.org/content/10.64898/2026.06.29.735330v117 Sep 2026 10:33 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvphcbh6hs27https://bsky.app/profile/bertogliolab.bsky.social/post/3mvph6ygt7s27MDMA enhances prefrontal plasticity and representational drift during fear extinction https://www.biorxiv.org/content/10.64898/2026.03.06.710094v117 Sep 2026 10:31 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvph6ygt7s27https://bsky.app/profile/bertogliolab.bsky.social/post/3mvph4rfm2k27Sex-specific frontal cortical circuit mechanisms mediating fear extinction https://www.biorxiv.org/content/10.64898/2026.04.10.717763v217 Sep 2026 10:30 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvph4rfm2k27https://bsky.app/profile/bertogliolab.bsky.social/post/3mvpgzbidhs27Silencing basal forebrain cholinergic input to the infralimbic cortex renders fear extinction resistant to renewal https://www.biorxiv.org/content/10.64898/2026.07.06.736678v217 Sep 2026 10:28 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvpgzbidhs27https://bsky.app/profile/bertogliolab.bsky.social/post/3mvpgvutbts27The serotonin transporter genotype x cumulative early-life stress interaction has opposite effects on anxiety-like behaviors in male and female rats https://www.biorxiv.org/content/10.64898/2026.09.04.749397v117 Sep 2026 10:26 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvpgvutbts27https://bsky.app/profile/bertogliolab.bsky.social/post/3mvpguyuzn227Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination https://www.biorxiv.org/content/10.64898/2026.03.08.710406v317 Sep 2026 10:26 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvpguyuzn227https://bsky.app/profile/bertogliolab.bsky.social/post/3mvpgt45fds27Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role for Tent5a in reconsolidation https://www.biorxiv.org/content/10.64898/2026.09.08.750076v117 Sep 2026 10:24 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvpgt45fds27https://bsky.app/profile/bertogliolab.bsky.social/post/3mvncj5qjgk2jHippocampal astrocytic sequences emerge during learning and memory recall https://www.nature.com/articles/s41593-026-02448-016 Sep 2026 14:02 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvncj5qjgk2jhttps://bsky.app/profile/bertogliolab.bsky.social/post/3mvn4a3lhck2d(+)-Trans-Cannabidiol Is an Agonist at Human CB2 Receptors https://doi.org/10.1002/prp2.7032516 Sep 2026 12:10 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvn4a3lhck2dhttps://bsky.app/profile/bertogliolab.bsky.social/post/3mvn44td2ns2dPrenatal Δ9-tetrahydrocannabinol exposure rewires glucocorticoid-hippocampal crosstalk and impairs memory under stress in adolescent rat offspring https://doi.org/10.1016/j.ejphar.2026.17932716 Sep 2026 12:08 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvn44td2ns2dhttps://bsky.app/profile/bertogliolab.bsky.social/post/3mvkocgq5rc23Learning reorganizes dendritic and stabilizes axon initial segment inhibitory synapses in CA1 pyramidal neurons https://www.nature.com/articles/s41467-026-77800-w15 Sep 2026 12:55 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvkocgq5rc23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvko3fjlg2235-HT2A receptor and psychedelics: a trip through the mechanisms of action and therapeutic potential in mental disorders https://www.nature.com/articles/s41398-026-04455-y15 Sep 2026 12:51 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvko3fjlg223https://bsky.app/profile/bertogliolab.bsky.social/post/3mvknubmoek23Overlapping representations in the ventral hippocampus support rapid fear memory retrieval https://www.nature.com/articles/s41593-026-02435-515 Sep 2026 12:47 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvknubmoek23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvknldd7es23The ventral hippocampus: computations, circuits and functions https://www.nature.com/articles/s41583-026-01078-615 Sep 2026 12:42 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvknldd7es23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvkncqx6gs23Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors https://www.cell.com/neuron/fulltext/S0896-6273(26)00642-215 Sep 2026 12:37 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvkncqx6gs23https://bsky.app/profile/bertogliolab.bsky.social/post/3mvkn7mtsms23Physical Activity Is Associated With Age-Related Differences in Hippocampal Macrostructure and Microstructure in Middle-Aged and Older Adults https://onlinelibrary.wiley.com/doi/10.1002/hipo.7013015 Sep 2026 12:36 +0000at://did:plc:3tcdl5knf4vlmm6momyghzrm/app.bsky.feed.post/3mvkn7mtsms23