Professor of Bioinformatics at Wageningen University and Leiden University. Natural product discovery, microbiomes, method development.https://bsky.app/profile/marnixmedema.bsky.socialhttps://bsky.app/profile/marnixmedema.bsky.social/post/3mj7uke4qrs2fNow out in @acs.org JACS Au, the manuscript by #BarbaraTerlouw et al. describing PARAS, a high-accuracy machine-learning algorithm to predict substrate specificities of nonribosomal peptide synthetase (NRPS) adenylation domains, key for estimating natural product structures from BGC sequence. 1/n11 Apr 2026 12:45 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3mj7uke4qrs2fhttps://bsky.app/profile/marnixmedema.bsky.social/post/3mheq3dyw7k2bCheck out this blog from @catarinacarolina.bsky.social on the story behind the paper: https://communities.springernature.com/posts/making-biosynthetic-diversity-clustering-scalable-and-accessible-the-creation-journey-behind-the-new-versions-of-big-scape-and-big-slice A story of overcoming challenges, careful engineering and collaborative teamwork. [contains quote post or other embedded content]19 Mar 2026 00:18 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3mheq3dyw7k2bhttps://bsky.app/profile/marnixmedema.bsky.social/post/3mgrgpkp2e22eAre you interested in how to predict functions of natural product biosynthetic gene clusters (BGCs) and their products? And/or do you love metallophores and would love to identify their producers in microbiomes? Check out @zachreitz.bsky.social 's new paper! https://elifesciences.org/articles/109154 1/n11 Mar 2026 08:10 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3mgrgpkp2e22ehttps://bsky.app/profile/marnixmedema.bsky.social/post/3mfr6ignwvk2vNow out in @natcomms.nature.com : versions 2.0 of both BiG-SCAPE and BiG-SLiCE! With significant speed and accuracy increases, as well as new interactive functionalities. Read the full paper here #openaccess: https://www.nature.com/articles/s41467-026-68733-526 Feb 2026 12:18 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3mfr6ignwvk2vhttps://bsky.app/profile/marnixmedema.bsky.social/post/3mfbedhk4ek23Come join us again in a next round of this massive online open science community effort! 💪 Sign up using the link in the thread. It’s great fun, and really helps the scientific community. What more can you ask? 🙂 [contains quote post or other embedded content]20 Feb 2026 05:20 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3mfbedhk4ek23https://bsky.app/profile/marnixmedema.bsky.social/post/3mfbedhk4ek23Come join us again in a next round of this massive online open science community effort! 💪 Sign up using the link in the thread. It’s great fun, and really helps the scientific community. What more can you ask? 🙂 [contains quote post or other embedded content]20 Feb 2026 05:20 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3mfbedhk4ek23https://bsky.app/profile/marnixmedema.bsky.social/post/3meo6gbjos22nI am delighted and feel honored to be appointed as chair of Bioinformatics at @w-u-r.bsky.social . I look forward to working with the team and with our collaborators worldwide on keeping bioinformatics science and education flourishing at WUR and beyond. https://www.wur.nl/en/news/marnix-medema-appointed-chair-bioinformatics-wur12 Feb 2026 14:13 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3meo6gbjos22nhttps://bsky.app/profile/marnixmedema.bsky.social/post/3m7u4aj2cvk2qGrab the chance to already pre-register for the MIBiG 5.0 annotathons that we plan to organize in spring 2026! [contains quote post or other embedded content]13 Dec 2025 07:44 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3m7u4aj2cvk2qhttps://bsky.app/profile/marnixmedema.bsky.social/post/3m7u422mswc2rNow available online: the new 2.0 version of gutSMASH, with capabilities to detect 12 new types of catabolic gene clusters relevant to gut microbiome ecology, as well as predictions of their regulation through transcription factor binding site detection. https://www.sciencedirect.com/science/article/pii/S0022283625006333?via%3Dihub13 Dec 2025 07:41 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3m7u422mswc2rhttps://bsky.app/profile/marnixmedema.bsky.social/post/3m7mpprcygs2lImpressed by the hyper modern campus of Shenzhen University of Advanced Technology. All built in just over one year... 😮10 Dec 2025 09:11 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3m7mpprcygs2lhttps://bsky.app/profile/marnixmedema.bsky.social/post/3m7mnnkm2z22wNow out in @asm.org #mSystems! https://journals.asm.org/doi/10.1128/msystems.01321-25 Congratulations to Robert and thanks to all collaborators. See thread below for a summary of the work, exploring the use of cross-species coexpression analyses to predict primary and secondary metabolic interactions in microbiomes. [contains quote post or other embedded content]10 Dec 2025 08:34 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3m7mnnkm2z22whttps://bsky.app/profile/marnixmedema.bsky.social/post/3m4dmhjrw5k2pKudos to @elenadelpup.bsky.social for this significant update to plantiSMASH! Try it out now... [contains quote post or other embedded content]29 Oct 2025 14:04 +0000at://did:plc:46o7vf7wxxodsfh2cuxpwsuy/app.bsky.feed.post/3m4dmhjrw5k2p