Professor of Biostatistics Vanderbilt University School of Medicine Expert Biostatistics Advisor FDA Center for Drug Evaluation and Research https://hbiostat.org https://fharrell.comhttps://bsky.app/profile/f2harrell.bsky.socialhttps://bsky.app/profile/f2harrell.bsky.social/post/3mkkmrfnk2k2h1-day online course May 11: Intro to R/RStudio & an efficient comprehensive R workflow, introducing the R rms package, enhancing regression analysis skills to be ready for the RMS 4-day course. Details and registration at hbiostat.org/course @amstatnews.bsky.social @instats.bsky.social #RStats https://hbiostat.org/course28 Apr 2026 12:50 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mkkmrfnk2k2hhttps://bsky.app/profile/f2harrell.bsky.social/post/3mjwul7zmls2oNew presentation: www.fharrell.com/talk/qrct/ #Statistics #StatsSky #clinicaltrials https://www.fharrell.com/talk/qrct/20 Apr 2026 16:17 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mjwul7zmls2ohttps://bsky.app/profile/f2harrell.bsky.social/post/3mjrltygct22sPython script for pretty-printing of R code files: https://github.com/harrelfe/rscripts/blob/master/prprint.md18 Apr 2026 13:57 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mjrltygct22shttps://bsky.app/profile/f2harrell.bsky.social/post/3mjpjqi3jyk2sI have a new favorite editor/IDE: Zed. Open-source, blazing fast, built-in AI operability, easy to use. Heard that lots of developers are dropping Visual Studio Code for Zed. Has R and Quarto extensions. zed.dev https://zed.dev17 Apr 2026 18:14 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mjpjqi3jyk2shttps://bsky.app/profile/f2harrell.bsky.social/post/3mjmgov47gk2jA fantastic reproducibility autopsy that makes me even more dubious of both microbiome & autism research than I was previously & more sickened by how scientific journals work. For them to make money capitalizing on free reviewer labor the least they can do is to be scientific quality gatekeepers. [contains quote post or other embedded content]16 Apr 2026 12:42 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mjmgov47gk2jhttps://bsky.app/profile/f2harrell.bsky.social/post/3mjhivlqaxk26A huge point about meta-analysis, which begs for reliance on individual patient-level data and adjusting for a full set of covariates. [contains quote post or other embedded content]14 Apr 2026 13:38 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mjhivlqaxk26https://bsky.app/profile/f2harrell.bsky.social/post/3mj33iwasak2qCausal by Design: new blog article on Statistical Thinking. fharrell.com/post/causal/ #Statistics #StatsSky #EpiSky https://fharrell.com/post/causal/09 Apr 2026 15:06 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mj33iwasak2qhttps://bsky.app/profile/f2harrell.bsky.social/post/3miyra5rxv22t1-day online course May 11: Intro to R/RStudio & an efficient comprehensive R workflow, introducing the R rms package, enhancing regression analysis skills to be ready for the RMS 4-day course. Details and registration at hbiostat.org/course @amstatnews.bsky.social @instats.bsky.social #RStats https://hbiostat.org/course08 Apr 2026 16:57 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3miyra5rxv22thttps://bsky.app/profile/f2harrell.bsky.social/post/3miwkbnslbk2fRegression Modeling Strategies 4-day virtual course May 14-15, 18-19. More than regression:principled flexible modeling, accuracy, interpretation, selection, stability, validation, Bayes, contrast w/ML &more. hbiostat.org/course @amstatnews.bsky.social @instats.bsky.social #Statistics #StatsSky https://hbiostat.org/course07 Apr 2026 19:47 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3miwkbnslbk2fhttps://bsky.app/profile/f2harrell.bsky.social/post/3mij6kxrqwk2x#Statistics thought of the day: Type I "errors" in frequentist statistics have always been misleading. The "error" exists only inside a stipulated world, not the real one. You cannot call something an error by assuming the very fact that would make it one. #StatsSky fharrell.com/post/journey02 Apr 2026 12:13 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mij6kxrqwk2xhttps://bsky.app/profile/f2harrell.bsky.social/post/3mij2sv6esk2gGot a personal email out of the blue for a ghost worker. Shameless.02 Apr 2026 11:06 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mij2sv6esk2ghttps://bsky.app/profile/f2harrell.bsky.social/post/3mie4omil3c23Sending ICE agents to catch undocumented immigrants who attend their child's U.S. Marines graduation ceremony. What does this say about people who think Trump is making America great again? [contains quote post or other embedded content]31 Mar 2026 11:56 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mie4omil3c23https://bsky.app/profile/f2harrell.bsky.social/post/3mie4axbtxc23Wow this is an impressive article from @verawil.de that I highly recommend. One question-how can one get away with "artificially censored at the moment her actual behavior diverges from the assigned strategy" without making some kind of severe independent censoring assumption? #StatsSky #EpiSky [contains quote post or other embedded content]31 Mar 2026 11:49 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mie4axbtxc23https://bsky.app/profile/f2harrell.bsky.social/post/3mi4yviwvac2sNice paper on effective sample size for Kaplan-Meier survival curve estimates: https://www.tandfonline.com/doi/full/10.1080/00031305.2025.2542390#d1e2236 #Statistics #StatsSky28 Mar 2026 16:00 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mi4yviwvac2shttps://bsky.app/profile/f2harrell.bsky.social/post/3mhspunb2nk2kCelebrating the draft FDA Bayesian guidance document with our perspective in @jama.com. Honored to co-author w/Jack Lee (MD Anderson), Lisa LaVange (past director of Office of Biostatistics FDA CDER&president of ASA),& my Bayesian inspiration Sir David Spiegelhalter https://jamanetwork.com/journals/jama/fullarticle/284701124 Mar 2026 13:52 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mhspunb2nk2khttps://bsky.app/profile/f2harrell.bsky.social/post/3mhnxsuiouk2fThe best things in life truly are free [contains quote post or other embedded content]22 Mar 2026 16:31 +0000at://did:plc:56hsqifm2ft7ql6slwcq5tix/app.bsky.feed.post/3mhnxsuiouk2f