Neuroscientist investigating neuronal bases of reward and learning. Associate Prof at Oxford University. www.laklab.orghttps://bsky.app/profile/laklab.bsky.socialhttps://bsky.app/profile/laklab.bsky.social/post/3mlqixkurds2rbig fomo for @dopaminesociety.bsky.social next week but excited that @jessicamoretti.bsky.social and @matthiasfritsche.bsky.social from the lab attending to present what we have been up to13 May 2026 14:23 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3mlqixkurds2rhttps://bsky.app/profile/laklab.bsky.social/post/3mle3snhbbk2zVery interesting stuff here [contains quote post or other embedded content]08 May 2026 15:56 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3mle3snhbbk2zhttps://bsky.app/profile/laklab.bsky.social/post/3mkbbtuchgs26We have new a new doctor in the lab 🍾🍾🎉Congratulations @neurorussell.bsky.social for successful viva today at Oxford @oxforddpag.bsky.social24 Apr 2026 19:41 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3mkbbtuchgs26https://bsky.app/profile/laklab.bsky.social/post/3mjf2inwdzc2dAmazing study and the coolest results (from my point of view!) is that LC norepinephrine neurons projecting to the frontal cortex encode reward prediction error [contains quote post or other embedded content]13 Apr 2026 14:15 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3mjf2inwdzc2dhttps://bsky.app/profile/laklab.bsky.social/post/3mh4ub6xztc2bbombs falling to plant democracy! , but instead fertilising despair and taking lives… writing right after hearing that a few days ago bombs landed some 50 m from my father’s office …. [contains quote post or other embedded content]15 Mar 2026 21:12 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3mh4ub6xztc2bhttps://bsky.app/profile/laklab.bsky.social/post/3mdngos6ios2jRA job alert. We are looking for a fearless experimentalist to join our experiments on cortical neuromodulators during visually guided learning, lead by @michael-lynn.bsky.social . Opportunity to learn 2p imaging, design and conduct experiments. RT plz. Apply here: https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form?p_company=10&p_internal_external=E&p_display_in_irish=N&p_process_type=&p_applicant_no=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y&p_recruitment_id=18459830 Jan 2026 13:43 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3mdngos6ios2jhttps://bsky.app/profile/laklab.bsky.social/post/3mcfm5jbpjk25This one from @kepecslab.bsky.social and Song Hu lab is awesome: https://www.nature.com/articles/s41593-025-02106-x14 Jan 2026 17:34 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3mcfm5jbpjk25https://bsky.app/profile/laklab.bsky.social/post/3mbobchsyrc2tNew preprint. We show that in addition to reward prediction errors (RPEs), dorsal striatal dopamine signals encode sensory prediction errors (SPEs), the difference between sensory prior & observed stimulus. https://www.biorxiv.org/content/10.64898/2026.01.01.696999v105 Jan 2026 10:49 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3mbobchsyrc2thttps://bsky.app/profile/laklab.bsky.social/post/3m6ffzsgndc2uconcise and informative review article on corticostriatal pathways in sensory process by @giladsilberberg.bsky.social et al . I find myself looking into it frequently and learn/cross check a new thing every time : https://www.sciencedirect.com/science/article/pii/S095943882300106X24 Nov 2025 18:04 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3m6ffzsgndc2uhttps://bsky.app/profile/laklab.bsky.social/post/3m5j2cztjpc2jWe look forward to discussing these with you all #SfN25, #SfN202513 Nov 2025 11:20 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3m5j2cztjpc2jhttps://bsky.app/profile/laklab.bsky.social/post/3m3czjh66222mOut today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream connectivity of neurons, revealing a structured, multi-scale code for economic variables. https://www.cell.com/neuron/fulltext/S0896-6273(25)00715-916 Oct 2025 14:59 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3m3czjh66222mhttps://bsky.app/profile/laklab.bsky.social/post/3m2yp4cqwzs2pAll-optical experiments are great but @neurorussell.bsky.social found that opsin desensitization due to cross-talk between the imaging laser and the opsin causes major issues. These can be ameleorated with long inter-stimulus intervals & short imaging doses. All here: https://www.biorxiv.org/content/10.1101/2025.10.02.680058v1 https://www.biorxiv.org/content/10.1101/2025.10.02.680058v1.full12 Oct 2025 12:27 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3m2yp4cqwzs2phttps://bsky.app/profile/laklab.bsky.social/post/3lzbbzafrys26Beautiful and clear results showing that temporal difference error calculation is hardwired in the dopamine/striatum mircocircuits: https://www.biorxiv.org/content/10.1101/2025.09.18.677203v1 from @malcolmgcampbell.bsky.social and @naoshigeuchida.bsky.social20 Sep 2025 11:36 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3lzbbzafrys26https://bsky.app/profile/laklab.bsky.social/post/3lygabmyvk22bConcise and informative highlight on our recent paper, thanks to Seung Chan Kim, Sehwan Kim & Sang Ryong Kim. https://www.nature.com/articles/s41392-025-02406-509 Sep 2025 17:23 +0000at://did:plc:56ln3tzeadvxck44bttutjch/app.bsky.feed.post/3lygabmyvk22b