Harvard-based consortium curating structural biology (CryoEM Crystallography NMR Tomography) software, hosting educational webinars, supporting reproducibility, validation, reprocessing of data, & access to scientific resources sbgrid.org / biogrids.orghttps://bsky.app/profile/sbgrid.bsky.socialhttps://bsky.app/profile/sbgrid.bsky.social/post/3mj5pb7s3yf2sNew Title Alert: MemBrain-v2- is a tool that includes MemBrain-seg, MemBrain-pick, MemBrain-stats, and several Napari tools. Learn more here: buff.ly/U3s12Ic #SBGrid #SBGridSoftware https://buff.ly/U3s12Ic10 Apr 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mj5pb7s3yf2shttps://bsky.app/profile/sbgrid.bsky.social/post/3mj36rvz6ij2ySBGrid updated the wiki to include guidance for new & existing users. Our revised installation instructions provide clearer instructions for setting up SBGrid buff.ly/5QhSXOR Expanded Using SBGrid documentation provides more detailed guidance on working w/in the SBGrid environment: buff.ly/rs7dV0l https://buff.ly/5QhSXOR09 Apr 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mj36rvz6ij2yhttps://bsky.app/profile/sbgrid.bsky.social/post/3miyoehqpbc2kNew Title Alert: AFmassive- is a modified AlphaFold implementation for massive conformational sampling, derived from AlphaFold v2.3.2 and designed to integrate with MassiveFold for parallelized prediction workflows. Learn more here: buff.ly/jPxTEV0 #SBGrid #SBGridSoftware https://buff.ly/jPxTEV008 Apr 2026 16:06 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3miyoehqpbc2khttps://bsky.app/profile/sbgrid.bsky.social/post/3miw5tsk76l2sSBGrid's eLife paper received a citation in March from K. Christopher Garcia from @stanford.edu School of Medicine in @science.org: Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering. Read more here: buff.ly/WnBw3wr #SBGrid #StayConnected #ScienceMatters https://buff.ly/WnBw3wr07 Apr 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3miw5tsk76l2shttps://bsky.app/profile/sbgrid.bsky.social/post/3mitnali5q322Technical Notes: March's software push includes updates to AlphaPulldown, AreTomo, Coot, CCP4, CryoLithe, DIALS, Doppio, Java, MPicker, OpenFreeEenergy, Open Force Field, qfit, SAMtools, Schrodinger, Scipion, and Xmipp. More here: buff.ly/WXLwT6q #SBGrid #Software #StructuralBiology https://buff.ly/WXLwT6q06 Apr 2026 16:02 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mitnali5q322https://bsky.app/profile/sbgrid.bsky.social/post/3mim677jsti22New Title Alert: PXDesign- is a de novo protein-binder design suite combining a diffusion generator (PXDesign-d) with Protenix and AF2-IG confidence models for candidate selection and ranking. Learn more here: buff.ly/s455Ck8 #SBGrid #SBGridSoftware https://buff.ly/s455Ck803 Apr 2026 16:45 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mim677jsti22https://bsky.app/profile/sbgrid.bsky.social/post/3mim3rdq3j32hOur member tale for March features @palencialab.bsky.social from @inserm.fr in Grenoble, France where his group is harnessing the matchmaking qualities of the LeuRS enzyme in efforts to advance a new class of drugs to tackle drug-resistant bacteria & parasites. Read more here: https://buff.ly/XOOPQHf03 Apr 2026 16:01 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mim3rdq3j32hhttps://bsky.app/profile/sbgrid.bsky.social/post/3mijmw3uixx2bSBGrid's eLife paper received a citation in February from @cryoet.bsky.social from @jhu.edu School of Medicine and Dylan Hale (now at University of Pittsburgh) in @natcomms.nature.com. Read more here: buff.ly/kx5Fiaw #SBGrid #Stayconnected02 Apr 2026 16:30 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mijmw3uixx2bhttps://bsky.app/profile/sbgrid.bsky.social/post/3mic24zirhj2uSBGrid's eLife paper received a citation in February from Philip Kranzusch from @danafarber.bsky.social in @Nature: Nucleotide signals coordinate activation and inhibition of bacterial immunity. Read more here: buff.ly/CFikpvv #SBGrid #StayConnected https://buff.ly/CFikpvv30 Mar 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mic24zirhj2uhttps://bsky.app/profile/sbgrid.bsky.social/post/3mi2ipppjly2sSBGrid's eLife paper received a citation in February from Anthony Kossiakoff from The University of Chicago in @pnas.org : Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating. Read more here: buff.ly/3Oawrum #SBGrid #ScienceMatters https://buff.ly/3Oawrum27 Mar 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mi2ipppjly2shttps://bsky.app/profile/sbgrid.bsky.social/post/3mhxy73gdhc2mNew Title Alert: vossvolvox- a C++17 command-line tools for analyzing molecular structures, specifically for computing volumes, channels, cavities, and tunnel geometry from various molecular input formats. Learn more here: buff.ly/0ff33pF #SBGrid #SBGridSoftware https://buff.ly/0ff33pF26 Mar 2026 16:04 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhxy73gdhc2mhttps://bsky.app/profile/sbgrid.bsky.social/post/3mhvhtefccp26SBGrid's eLife paper received a citation in February from Alireza Ghanbarpour from Washington University School of Medicine in St. Louis, in @Nature: Bacterial immune activation via supramolecular assembly with phage triggers. Read more here: buff.ly/vgiNzUl #SBGrid #ScienceMatters https://buff.ly/vgiNzUl25 Mar 2026 16:06 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhvhtefccp26https://bsky.app/profile/sbgrid.bsky.social/post/3mhsxdicwu42tTechnical Notes: Phenix 2 / Coot 1 integration update: The Phenix/Coot GUI integration is not currently working; the Phenix developers are targeting a fix for their next official release.24 Mar 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhsxdicwu42thttps://bsky.app/profile/sbgrid.bsky.social/post/3mhqgnvxmvc2ySBGrid's eLife paper received a citation in February from Christopher Garcia from @stanforduniversity.bsky.social School of Medicine in @science.org: Structural ontogeny of protein-protein interactions. Read more here: buff.ly/BPRhfUL #SBGrid #ScienceMatters https://buff.ly/BPRhfUL23 Mar 2026 16:02 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhqgnvxmvc2yhttps://bsky.app/profile/sbgrid.bsky.social/post/3mhpzbz2mkn27SBGrid's eLife paper received a citation in February from Eric Fischer from @danafarber.bsky.social in @natchembio.nature.com High-throughput ligand diversification to discover chemical inducers of proximity. Read more here: buff.ly/Z9db5GU #SBGrid #StayConnected23 Mar 2026 12:02 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhpzbz2mkn27https://bsky.app/profile/sbgrid.bsky.social/post/3mhivhdu27n2oWe've published some initial documentation on using individual or group SBGrid installations on HPC resources where creating a `/programs/` link is problematic. Please contact us at accounts@sbgrid.org if you encounter problems. Learn more here: https://buff.ly/W2JfmU820 Mar 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhivhdu27n2ohttps://bsky.app/profile/sbgrid.bsky.social/post/3mhdxqgnn6m2rIn case you missed Joshua Mitchell webinar featuring Open Force Field Initiative, it is now available in our YouTube channel. More here: buff.ly/6tzRrM8 #SBGrid #Webinars #ScienceMatters https://youtu.be/4tyxCzrBreQ18 Mar 2026 17:03 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhdxqgnn6m2rhttps://bsky.app/profile/sbgrid.bsky.social/post/3mhdvwcctxv27Member News: SBGrid member Andrew Kruse, professor of biological chemistry & molecular pharmacology in the Blavatnik Institute at HMS is featured in The Harvard Gazette for his discovery offering hope for patients with hard-to-treat heart disease. Read more here: buff.ly/ZZjaGtZ #SBGrid #Members https://buff.ly/ZZjaGtZ18 Mar 2026 16:30 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhdvwcctxv27https://bsky.app/profile/sbgrid.bsky.social/post/3mhbfilpimd2uSBGrid's eLife paper received a citation in February from Elizabeth Wright from @uwmadison.bsky.social in @natprot.nature.com : Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET. Read more here: buff.ly/EGZomRA #SBGrid #ScienceMatters https://buff.ly/EGZomRA17 Mar 2026 16:31 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhbfilpimd2uhttps://bsky.app/profile/sbgrid.bsky.social/post/3mhbe2s4aa62uNew Title Alert: mBER-open- is a protein design framework for antibody binder design that leverages structure templates and sequence conditioning in backpropagation-based design through AlphaFold-Multimer. Learn more here: buff.ly/59LkTAm #SBGrid #SBGridSoftware https://buff.ly/59LkTAm17 Mar 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhbe2s4aa62uhttps://bsky.app/profile/sbgrid.bsky.social/post/3mhbd6zmv2p2oA postdoc fellowship & postbac position are available in the Cell Biology & Biophysics Unit headed by Dr. Antonina Roll-Mecak. Please send your CV, research experience summary & contact info of three references to Antonina@nih.gov Please write “Tubulin code” in the subject header.17 Mar 2026 15:50 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhbd6zmv2p2ohttps://bsky.app/profile/sbgrid.bsky.social/post/3mhbcwgqa3w27SBGrid's eLife paper received a citation in February from James Berger from @jhu.edu School of Medicine in @natcomms.nature.com : Supercoiled DNA recognition and cleavage control in topoisomerase VI. Read more here: buff.ly/tKmGHHK #SBGrid #ScienceMatters17 Mar 2026 15:45 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhbcwgqa3w27https://bsky.app/profile/sbgrid.bsky.social/post/3mhbc47juue2rSBGrid's eLife paper received a citation in February from John Pascal from Université de Montréal (University of Montreal) in @natcomms.nature.com : PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation. Read more here: buff.ly/VbygZD2 #SBGrid17 Mar 2026 15:30 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mhbc47juue2rhttps://bsky.app/profile/sbgrid.bsky.social/post/3mgxdltcywb27New Member Alert: Dylan Hale from University of Pittsburgh joined SBGrid in February. Welcome!!13 Mar 2026 16:30 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mgxdltcywb27https://bsky.app/profile/sbgrid.bsky.social/post/3mgxc6ljg5e24New Title Alert: easymode- a collection of general pretrained networks for cellular cryoET. Learn more here: buff.ly/mLbcUbZ #SBGrid #SBGridSoftware https://buff.ly/mLbcUbZ13 Mar 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mgxc6ljg5e24https://bsky.app/profile/sbgrid.bsky.social/post/3mgsb7sbvb42rNews Alert: We've updated SBGrid's primary citation to our 2024 Acta Crystallographica paper. We would be grateful if you could use this reference in future manuscripts, preprints, and related work where appropriate. Read it here: buff.ly/RQ0Ybpx #SBGrid #Citation https://pubmed.ncbi.nlm.nih.gov/38832828/11 Mar 2026 16:04 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mgsb7sbvb42rhttps://bsky.app/profile/sbgrid.bsky.social/post/3mgpqrtsaz52oTechnical Notes: This month's software push includes updates to Ais, AlphaFold3, Boltzgen, Bowtie2, CellProfiler, ChimeraX, CryoMaskR, CryoSPARC-tools, Foldseek, IsoNet2, Protenix, RDKit, and upside2-md. More here: buff.ly/SHUsfWz #SBGrid #Software #StructuralBiology https://buff.ly/SHUsfWz10 Mar 2026 16:05 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mgpqrtsaz52ohttps://bsky.app/profile/sbgrid.bsky.social/post/3mgnae5p5vg2yJoin our software webinar on March 10th to hear from Joshua Mitchell from the Open Molecular Software Foundation on Open Force Field Initiative. ' Tues, March 10, 2026 12:00PM ET Josh Mitchell Science Communicator, Open Force Field Register here: buff.ly/YVCdTmr #SBGrid #StructuralBiology https://buff.ly/YVCdTmr09 Mar 2026 16:06 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mgnae5p5vg2yhttps://bsky.app/profile/sbgrid.bsky.social/post/3mgfvfpbgfu2zSBGrid's eLife paper received a citation in February from Woonghee Lee from University of Colorado Denver in Journal of Biological Chemistry: Modernizing Biomolecular NMR: the POKY Suite. Read more here: buff.ly/7ys6qCM #SBGrid #ScienceMatters https://buff.ly/7ys6qCM06 Mar 2026 18:01 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mgfvfpbgfu2zhttps://bsky.app/profile/sbgrid.bsky.social/post/3mgfsafa3x62yNew Member Alert: @krishnareddy.bsky.social from @usf.edu joined SBGrid in February. Welcome!!06 Mar 2026 17:04 +0000at://did:plc:5dsgexwn4fa4pc7evaxjvulp/app.bsky.feed.post/3mgfsafa3x62y