Assistant Professor of Biochemistry and Biophysics, University of Pennsylvania https://www.yiweichanglab.org/ Structural biology; cryo-electron tomography; host-pathogen interactionshttps://bsky.app/profile/yiweichang.bsky.socialhttps://bsky.app/profile/yiweichang.bsky.social/post/3m7prykhxys24Congratulations to Melanie Ohi for this very well-deserved recognition! [contains quote post or other embedded content]11 Dec 2025 14:30 +0000at://did:plc:5zwerrqlgeim7yml3ha46b4y/app.bsky.feed.post/3m7prykhxys24https://bsky.app/profile/yiweichang.bsky.social/post/3lpabyglrj22lExcited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. https://www.science.org/doi/10.1126/science.adq759715 May 2025 19:51 +0000at://did:plc:5zwerrqlgeim7yml3ha46b4y/app.bsky.feed.post/3lpabyglrj22lhttps://bsky.app/profile/yiweichang.bsky.social/post/3lggk7u5tcs2oThrilled to share that our work with the Ben Black Lab, led by a co-mentored star MD/PhD student Katie Kixmoeller, now is formally published! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️ https://authors.elsevier.com/c/1kUW9L7PXqT5H23 Jan 2025 18:47 +0000at://did:plc:5zwerrqlgeim7yml3ha46b4y/app.bsky.feed.post/3lggk7u5tcs2o