Consultant and senior lecturer in medical oncology, University of Bristol. Breast cancer, clinical trials and harm v benefit. Rides a bike sometimeshttps://bsky.app/profile/drtimrobinson.bsky.socialhttps://bsky.app/profile/drtimrobinson.bsky.social/post/3lbyouenoas25The SONIA trial shows the utility of well-designed academic trials. But funding such studies is getting harder and harder. We need to work with industry to design smarter trials that don’t need further costly and lengthy trials to fill gaps https://www.nature.com/articles/d41586-024-03838-9 @oncoalert.bsky.social #bcsm28 Nov 2024 08:52 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3lbyouenoas25https://bsky.app/profile/drtimrobinson.bsky.social/post/3lbyntozlls25This is potentially very interesting data but follow up is short at this point and would want to see an EFS/OS outcome. Does provide early signal and could be useful for those where steroids are contraindicated or problematic [contains quote post or other embedded content]28 Nov 2024 08:34 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3lbyntozlls25https://bsky.app/profile/drtimrobinson.bsky.social/post/3lbtkm5vpp22bNice review! I’m sure we will have combination strategies in the clinic on the next few years but must balance efficacy with cost/side effect profiles [contains quote post or other embedded content]26 Nov 2024 07:53 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3lbtkm5vpp22bhttps://bsky.app/profile/drtimrobinson.bsky.social/post/3lbmwoefkvc2sYep quoting to keep the links! [contains quote post or other embedded content]23 Nov 2024 16:40 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3lbmwoefkvc2shttps://bsky.app/profile/drtimrobinson.bsky.social/post/3lbmw6r4cgk2sReassuring BUT short follow up at this time point [contains quote post or other embedded content]23 Nov 2024 16:31 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3lbmw6r4cgk2shttps://bsky.app/profile/drtimrobinson.bsky.social/post/3lbhqos3p6s2hInteresting results, be nice to see these replicated in other eTNBC IO trials. Also to explore links with irAEs [contains quote post or other embedded content]21 Nov 2024 15:10 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3lbhqos3p6s2hhttps://bsky.app/profile/drtimrobinson.bsky.social/post/3lbh65ca65k2hAnecdotally, seeing an awful lot of younger patients with TNBC coming through MDT. Is anyone else seeing this?21 Nov 2024 09:38 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3lbh65ca65k2hhttps://bsky.app/profile/drtimrobinson.bsky.social/post/3lbf3mo2vys26I’m excited to see data at #SABCS but I’m also mindful that we are adding more and more to treatments and feel like we’re reaching the point that we need to start trying smarter patient selection to prevent harm @oncoalert.bsky.social #oncsky20 Nov 2024 13:47 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3lbf3mo2vys26https://bsky.app/profile/drtimrobinson.bsky.social/post/3lbain4473c2lWe really need some better biomarkers for immunotherapy toxicity…. Im worried we’re storing up psome big issues down the line18 Nov 2024 17:57 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3lbain4473c2lhttps://bsky.app/profile/drtimrobinson.bsky.social/post/3laoprzqpqk2rWell this seems rather pleasant compared to… you know the other place11 Nov 2024 16:17 +0000at://did:plc:65slphpked67cnuufyyeee5z/app.bsky.feed.post/3laoprzqpqk2r