Located at @TelAvivUni. We study the molecular basis of information transfer within ion channels and prenyltransferases. haitinlab.sites.tau.ac.il https://bsky.app/profile/haitinlab.bsky.socialhttps://bsky.app/profile/haitinlab.bsky.social/post/3mqu4jazh3s2z🚨One probe. 🧪One assay. 👯Two answers. Our new fluorescent platform identifies prenylation inhibitors and reveals how they work, streamlining both screening and mechanistic studies! Full text here: https://www.tandfonline.com/doi/full/10.1080/14756366.2026.2700494 @telavivuni.bsky.social #MedicinalChemistry #DrugDiscovery17 Jul 2026 15:57 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3mqu4jazh3s2zhttps://bsky.app/profile/haitinlab.bsky.social/post/3mqu4jazh3s2z🚨One probe. 🧪One assay. 👯Two answers. Our new fluorescent platform identifies prenylation inhibitors and reveals how they work, streamlining both screening and mechanistic studies! Full text here: https://www.tandfonline.com/doi/full/10.1080/14756366.2026.2700494 @telavivuni.bsky.social #MedicinalChemistry #DrugDiscovery17 Jul 2026 15:57 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3mqu4jazh3s2zhttps://bsky.app/profile/haitinlab.bsky.social/post/3mnfj55nges2iExcited to share our new paper in @proteinsociety.bsky.social 🎉 We combine #BioEmu and SAXS ensemble optimization to characterize protein conformational heterogeneity, bridging AI-generated ensembles and experimental data. doi.org/10.1002/pro.70… #SAXS #MachineLearning https://doi.org/10.1002/pro.70…03 Jun 2026 16:18 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3mnfj55nges2ihttps://bsky.app/profile/haitinlab.bsky.social/post/3mnfj55nges2iExcited to share our new paper in @proteinsociety.bsky.social 🎉 We combine #BioEmu and SAXS ensemble optimization to characterize protein conformational heterogeneity, bridging AI-generated ensembles and experimental data. doi.org/10.1002/pro.70… #SAXS #MachineLearning https://doi.org/10.1002/pro.70…03 Jun 2026 16:18 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3mnfj55nges2ihttps://bsky.app/profile/haitinlab.bsky.social/post/3lb5p4cffak2qHi!17 Nov 2024 15:15 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3lb5p4cffak2qhttps://bsky.app/profile/haitinlab.bsky.social/post/3m6tuffahos2j🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms , revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl https://rdcu.be/eShjl30 Nov 2025 11:59 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3m6tuffahos2jhttps://bsky.app/profile/haitinlab.bsky.social/post/3ltez3knmxc2lExcited to share our new paper in @febsj.bsky.social! 🎉 We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation 🔗 http://doi.org/10.1111/febs.70181 @peterslab1.bsky.social [contains quote post or other embedded content]07 Jul 2025 14:35 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3ltez3knmxc2lhttps://bsky.app/profile/haitinlab.bsky.social/post/3lqnimrxd5s2wHow does a cytoplasmic enzyme make a membrane product? 🤔🧬 We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane! MD simulations + fluorescence = mechanistic insight 👇 🔗https://doi.org/10.1002/pro.7016702 Jun 2025 19:19 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3lqnimrxd5s2whttps://bsky.app/profile/haitinlab.bsky.social/post/3lovz4zcts22dBut your results are 🔥 as usual! [contains quote post or other embedded content]11 May 2025 17:46 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3lovz4zcts22dhttps://bsky.app/profile/haitinlab.bsky.social/post/3lovmctmqr22j💃🕺Happy to share a team effort to uncover the molecular "dance" behind human cis-prenyltransferase regulation!🔬🧬 @peterslab1.bsky.social @AlbGiacomello #Biochemistry #StructuralBiology @TAUMedFaculty @of_sagol https://biorxiv.org/content/10.1101/2025.05.09.652838v111 May 2025 13:56 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3lovmctmqr22jhttps://bsky.app/profile/haitinlab.bsky.social/post/3leqo5zuodc2j🥳 [contains quote post or other embedded content]02 Jan 2025 08:34 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3leqo5zuodc2jhttps://bsky.app/profile/haitinlab.bsky.social/post/3le76gtsa7k2b🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma http://bit.ly/3ZR7w4726 Dec 2024 09:37 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3le76gtsa7k2bhttps://bsky.app/profile/haitinlab.bsky.social/post/3lb5p4cffak2qHi!17 Nov 2024 15:15 +0000at://did:plc:6asxp72fdyrdddrsdvc4offh/app.bsky.feed.post/3lb5p4cffak2q