Passionate about #immunology. Sensing damaged self, infections & microbiota by DCs and macrophages to ignite innate & adaptive immunity. #Immunometabolism Professor of Immunology @CNIC, Madrid, Spain. https://www.cnic.es/en/investigacion/immunobiologyhttps://bsky.app/profile/sancholab.bsky.socialhttps://bsky.app/profile/sancholab.bsky.social/post/3mmymkq5r5s24How does oxygen sensing shape #alveolar #macrophage (AM) identity? Our new @cp-cellreports.bsky.social: HIF-1α and HIF-2α play distinct, non-redundant roles in AM maturation & function A #metabolic split that defines macrophage biology in the lung. 🔗 https://doi.org/10.1016/j.celrep.2026.117447 #CNIC #immunosky29 May 2026 13:14 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3mmymkq5r5s24https://bsky.app/profile/sancholab.bsky.social/post/3mmpfcdvf222bDoes mitochondrial respiration in DCs just “fuel” activation? In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s https://www.science.org/doi/10.1126/sciimmunol.aef0098 At: CNIC_CARDIO @inmunosky25 May 2026 21:10 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3mmpfcdvf222bhttps://bsky.app/profile/sancholab.bsky.social/post/3mjqwn4mmyk2p🤔Do you think that OXPHOS in DCs = tolerance? In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance. Life (& #immunometabolism) is not simple ⚡️ OPEN: https://www.cell.com/cell-metabolism/fulltext/S1550-4131%2826%2900106-3 #immunoSky18 Apr 2026 07:38 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3mjqwn4mmyk2phttps://bsky.app/profile/sancholab.bsky.social/post/3mesxh7nw6s2x#PhD in #immunometabolism on fatty acid oxidation in #macrophage function. MSCA-DN: https://unimedizin-mainz.de/unlimited-msca/consortium.html For our DC8 position apply in parallel in 2 sites: 1. https://unimedizin-mainz.de/unlimited-msca/how-to-apply.html 2. https://cnic.es/en/convocatoria/predoctoral-researcher-group-immunobiology (DC8: NOT resident in Spain >12m in last 3 years) #immunosky14 Feb 2026 11:52 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3mesxh7nw6s2xhttps://bsky.app/profile/sancholab.bsky.social/post/3mesxcud3l22xGreat opportunity for a #PhD on how lipid #metabolism regulates immune cell function in diseases such as cancer and autoimmunity. Train in immunology, bioIT, & metabolism. Apply in parallel in: 1. UNLIMITED: https://www.unimedizin-mainz.de/unlimited-msca/consortium.html 2. Local partner site that you choose. #immunosky14 Feb 2026 11:49 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3mesxcud3l22xhttps://bsky.app/profile/sancholab.bsky.social/post/3meswsyexqc2xExcessive #inflammation? We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: https://www.cell.com/immunity/fulltext/S1074-7613%2825%2900566-7 #immunosky14 Feb 2026 11:40 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3meswsyexqc2xhttps://bsky.app/profile/sancholab.bsky.social/post/3mcxfiahwdc2bDon't miss the 2nd Conference of the European ImmunoMetabolism Network - EIMN2026 📅10-12th June 2026 📌Luxembourg immunometnet.eu @immunometeurope.bsky.social https://linkedin.comevents/2ndconferenceoftheeuropeanimmun7419020716488065024/21 Jan 2026 19:23 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3mcxfiahwdc2bhttps://bsky.app/profile/sancholab.bsky.social/post/3lurqj3jwas2nGracias @caixaresearch.bsky.social por el sólido apoyo a nuestra investigación. Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.325792 También apoyo fundamental en: https://www.nature.com/articles/s41586-025-09263-w [contains quote post or other embedded content]25 Jul 2025 09:32 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3lurqj3jwas2nhttps://bsky.app/profile/sancholab.bsky.social/post/3lucmgqb4222dA gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment|ERC https://erc.europa.eu/news-events/news/gut-microbiota-metabolite-linked-atherosclerosis-could-revolutionise-diagnosis-and19 Jul 2025 09:09 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3lucmgqb4222dhttps://bsky.app/profile/sancholab.bsky.social/post/3lu67pyiaas2cFantástico resumen por @manuelansede.bsky.social 🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón € 🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab 🙏 @erc.europa.eu ERC-CoG ERC-POC #CNIC_CARDIO Open acess: https://www.nature.com/articles/s41586-025-09263-w [contains quote post or other embedded content]17 Jul 2025 15:11 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3lu67pyiaas2chttps://bsky.app/profile/sancholab.bsky.social/post/3lu3xerwyzc2v💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. https://nature.com/articles/s41586-025-09263-w #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky16 Jul 2025 17:36 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3lu3xerwyzc2vhttps://bsky.app/profile/sancholab.bsky.social/post/3lsuzthxbs22lCongrats @iannaconelab.bsky.social & team on a wonderful work @natimmunol.nature.com on the immune regulation in the liver: CD4+ T cells license Kupffer cells to rescue CD8+ T cells through IL12 & mainly IL27. Highly relevant for liver immunotherapy!!! 👏🏻👏🏻👏🏻👏🏻👏🏻 #immunosky 👇🏻👇🏻👇🏻 [contains quote post or other embedded content]01 Jul 2025 06:06 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3lsuzthxbs22lhttps://bsky.app/profile/sancholab.bsky.social/post/3ls7mjbtb3s27🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles. 🔗 https://doi.org/10.1161/CIRCRESAHA.124.325792 #Immunotherapy #Atherosclerosis #Nanomedicine #CNIC_CARDIO #immunosky #cardiosky22 Jun 2025 17:42 +0000at://did:plc:6ny7n2pub2uclk56f2tkmaop/app.bsky.feed.post/3ls7mjbtb3s27