The official Bluesky account of https://psoriasisclub.org *Please note we do not answer questions here about psoriasis, you will need to join our forum where you will find a friendly bunch of people sharing support and information. https://bsky.app/profile/psoriasisclub.orghttps://bsky.app/profile/psoriasisclub.org/post/3mjrdpvxgps25This multicentre retrospective study in Germany looked at patients with erythrodermic psoriasis using a wide variety of treatments. #Psoriasis https://psoriasisclub.org/thread-8463.html18 Apr 2026 11:32 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mjrdpvxgps25https://bsky.app/profile/psoriasisclub.org/post/3mjrb2j3ygk25How demographics and family history redefine clearance predictions in psoriasis patients treated with biologics. #Psoriasis https://psoriasisclub.org/thread-8462.html18 Apr 2026 10:44 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mjrb2j3ygk25https://bsky.app/profile/psoriasisclub.org/post/3mjjv46buts2vThis study looked at the effectiveness of interleukin-17 inhibitors (IL-17i) in treating anti-TNF-induced Paradoxical psoriasis (PP) in patients with Hidradenitis Suppurativa (HS) #Psoriasis https://psoriasisclub.org/thread-8461.html15 Apr 2026 12:22 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mjjv46buts2vhttps://bsky.app/profile/psoriasisclub.org/post/3mjjujf3jvc2vThis study constructed a gene carrier with transdermal transfection capabilities, providing a new approach for gene delivery. This system achieves significant therapeutic effects in immune diseases like psoriasis. #Psoriasis https://psoriasisclub.org/thread-8460.html15 Apr 2026 12:11 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mjjujf3jvc2vhttps://bsky.app/profile/psoriasisclub.org/post/3mj35mbkqdc2aWe seem to be stabilising and the forum is back online. [contains quote post or other embedded content]09 Apr 2026 15:44 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mj35mbkqdc2ahttps://bsky.app/profile/psoriasisclub.org/post/3mj2whroj5c2aWe are aware of some intermittent downtime on our forum and working to fix it. psoriasisclub.org https://psoriasisclub.org09 Apr 2026 13:36 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mj2whroj5c2ahttps://bsky.app/profile/psoriasisclub.org/post/3mj2s77ah2s2aGlucagon-like peptide-1 receptor (GLP-1RA) agonist therapy is associated with improvement in psoriatic arthritis (PsA) related and metabolic outcomes. #Psoriasis #Psoriaticarthritis https://psoriasisclub.org/thread-8458.html09 Apr 2026 12:20 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mj2s77ah2s2ahttps://bsky.app/profile/psoriasisclub.org/post/3minzxwrs5c2xAround one third of psoriasis patients experience skin pain, this study investigated what is going on. #Psoriasis https://psoriasisclub.org/thread-8457.html04 Apr 2026 10:34 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3minzxwrs5c2xhttps://bsky.app/profile/psoriasisclub.org/post/3midzudqnwk2gThis study aimed to investigate treatment resistance mechanisms in palmoplantar psoriasis and assess the contribution of IL-17, IL-23, and IL-36α to the differential diagnosis. #Psoriasis https://psoriasisclub.org/thread-8454.html31 Mar 2026 11:06 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3midzudqnwk2ghttps://bsky.app/profile/psoriasisclub.org/post/3midzhxlrrk2gThis study focused on the level of B-cell types in the whole blood of psoriasis patients and investigated the variability between Bregs and memory B cells and other classified B cells in the blood of psoriasis patients and healthy controls. #Psoriasis https://psoriasisclub.org/thread-8453.html31 Mar 2026 10:59 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3midzhxlrrk2ghttps://bsky.app/profile/psoriasisclub.org/post/3mi6vljadzk2gEnvudeucitinib is a next-generation oral allosteric inhibitor of tyrosine kinase 2 (TYK2) precision‑engineered for maximal 24‑hour TYK2 inhibition to correct immune dysregulation driven by proinflammatory mediators including IL-23 & IL-17 #Psoriasis https://psoriasisclub.org/thread-8452.html29 Mar 2026 10:06 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mi6vljadzk2ghttps://bsky.app/profile/psoriasisclub.org/post/3mi226zp2ts2dThis study aimed to characterise changes in the diversity and composition of oral fungal and bacterial communities in psoriasis patients before and after treatment with IL-17 inhibitors. #Psoriasis https://psoriasisclub.org/thread-8449.html27 Mar 2026 11:45 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mi226zp2ts2dhttps://bsky.app/profile/psoriasisclub.org/post/3mhsijuqm722jAdiponectin (APN) holds potential as an anti-psoriatic agent targeting Aurora kinase A (AURKA) and Forkhead transcription factor 1 (FOXM1) for the gene-targeted therapies in psoriasis treatment. #Psoriasis https://psoriasisclub.org/thread-8448.html24 Mar 2026 11:40 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mhsijuqm722jhttps://bsky.app/profile/psoriasisclub.org/post/3mhl2bzfw3s23This study analysed psoriasis-related mRNA microarray datasets, comprising 605 psoriatic plaque samples and 611 normal samples. These datasets were integrated into a cohort to systematically identify immune-related genes associated with psoriasis. #Psoriasis https://psoriasisclub.org/thread-8445.html21 Mar 2026 12:37 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mhl2bzfw3s23https://bsky.app/profile/psoriasisclub.org/post/3mhkzj5vza223This study examined the association between radiographic structural damage and physical function (PF) in psoriatic arthritis (PsA) #Psoriaticarthritis https://psoriasisclub.org/thread-8444.html21 Mar 2026 12:23 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mhkzj5vza223https://bsky.app/profile/psoriasisclub.org/post/3mhkulq347c23This study provides valuable insights into the role of glucocorticoid receptor (GR) expression in psoriasis and its subtypes. #Psoriasis #Psoriaticarthritis https://psoriasisclub.org/thread-8443.html21 Mar 2026 10:55 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mhkulq347c23https://bsky.app/profile/psoriasisclub.org/post/3mhg3bgeyr22yBlood based systemic inflammatory biomarkers are an easily accessible and cost effective tool for identifying psoriasis and partially mediating the association between psoriasis and depression. #Psoriasis #Depression https://psoriasisclub.org/thread-8440.html19 Mar 2026 13:11 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mhg3bgeyr22yhttps://bsky.app/profile/psoriasisclub.org/post/3mhdm55vmyk25Update: "Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved Icotyde (icotrokinra), an interleukin-23 (IL-23) receptor antagonist for the treatment of moderate-to-severe plaque psoriasis. #Psoriasis https://psoriasisclub.org/thread-8322-post-283580.html#pid28358018 Mar 2026 13:35 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mhdm55vmyk25https://bsky.app/profile/psoriasisclub.org/post/3mhb2fe4ggk2bThis study assessed longitudinal changes in serologic and virologic hepatitis B virus (HBV) markers and evaluated the incidence of HBV reactivation in patients with moderate-to-severe plaque psoriasis undergoing long-term biologic therapy. #Psoriasis https://psoriasisclub.org/thread-8436.html17 Mar 2026 13:12 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mhb2fe4ggk2bhttps://bsky.app/profile/psoriasisclub.org/post/3mhazhzazr22bThis study demonstrated that at the time of generalized pustular psoriasis (GPP) diagnosis, patients with GPP have a high burden of both psoriasis-related complications and non–psoriasis-related comorbidities. #Psoriasis https://psoriasisclub.org/thread-8435.html17 Mar 2026 12:56 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mhazhzazr22bhttps://bsky.app/profile/psoriasisclub.org/post/3mh3tf7fosk27Being independent with no advertising it's not easy to get our forum at "Psoriasis Club" noticed but recently we had a new member from Bluesky, so thank you to everyone that has given us a mention or repost. We appreciate it. 🙏 #Psoriasis psoriasisclub.org https://psoriasisclub.org15 Mar 2026 11:23 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mh3tf7fosk27https://bsky.app/profile/psoriasisclub.org/post/3mgwyjuycfs2nBimzelx better than Skyrizi in psoriatic arthritis first head to head study. #Psoriasis https://psoriasisclub.org/thread-8434.html13 Mar 2026 13:12 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mgwyjuycfs2nhttps://bsky.app/profile/psoriasisclub.org/post/3mgwxkxpa222nThis study provides a mechanistic foundation for luteolin-based interventions in psoriasis. #Psoriasis https://psoriasisclub.org/thread-8433.html13 Mar 2026 12:55 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mgwxkxpa222nhttps://bsky.app/profile/psoriasisclub.org/post/3mgrqpzikhk2kThis study demonstrated that strenuous exercise is associated with enhanced cutaneous, systemic, and enthesis-related inflammatory changes in an imiquimod (IMQ) induced psoriasis mouse model. #Psoriasis https://psoriasisclub.org/thread-8432.html11 Mar 2026 11:09 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mgrqpzikhk2khttps://bsky.app/profile/psoriasisclub.org/post/3mghmqfvnhs2iThis study found a non-linear positive relation between body roundness index (BRI) and Psoriasis (Pso) #Psoriasis https://psoriasisclub.org/thread-8429.html07 Mar 2026 10:31 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mghmqfvnhs2ihttps://bsky.app/profile/psoriasisclub.org/post/3mghlzgx6nk2iOcadusertib is a selective allosteric inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) RIPK1 inhibitors have shown potential for the treatment of psoriasis but thus far, none have been approve. #Psoriasis https://psoriasisclub.org/thread-8428.html07 Mar 2026 10:18 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3mghlzgx6nk2ihttps://bsky.app/profile/psoriasisclub.org/post/3meqjsue45k2jBalinatunfib is being developed as a potential new treatment for patients with psoriasis that selectively inhibits TNFR1 signalling to potentially stop or slow the disease-causing processes, while preserving signals initiated through TNFR2. #Psoriasis https://psoriasisclub.org/thread-8424.html13 Feb 2026 12:42 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3meqjsue45k2jhttps://bsky.app/profile/psoriasisclub.org/post/3meqhrlnj6s2jThese results suggest that the LIGHT/TNFSF14 axis may play a key role in regulating cytokine production by autoimmune cells and related pathways in psoriasis. #Psoriasis https://psoriasisclub.org/thread-8423.html13 Feb 2026 12:06 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3meqhrlnj6s2jhttps://bsky.app/profile/psoriasisclub.org/post/3meqh5lhu6c2jThis study identifies a novel role for G protein-coupled receptor 108 (GPR108) as a negative regulator of TLR7 signalling in psoriasis and may yield new therapeutic principles for managing psoriatic diseases. #Psoriasis https://psoriasisclub.org/thread-8422.html13 Feb 2026 11:55 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3meqh5lhu6c2jhttps://bsky.app/profile/psoriasisclub.org/post/3meiwnsxsks2mAlterations in neural innervation within psoriatic skin & delineate the functional contributions of sensory neuron-derived mediators, including ion channels, receptors, & neuropeptides in modulating psoriasis-associated immune dysregulation. #Psoriasis https://psoriasisclub.org/thread-8421.html10 Feb 2026 12:11 +0000at://did:plc:6ohdlnvgxa5yoisk6d46h442/app.bsky.feed.post/3meiwnsxsks2m