🔬Since 1976, Sanford Burnham Prebys has been dedicated to pushing biomedical discoveries faster and further toward clinical treatment and therapies that improve human lives. We translate science into health. https://sbpdiscovery.orghttps://bsky.app/profile/sbpdiscovery.bsky.socialhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3mjncevlnss2aThe Freeze lab and an international team of collaborators discovered a new rare genetic disease that interferes with brain development. They published findings in @hggadvances.bsky.social that identify the faulty mutated gene and show how it interferes with normal cellular function. bit.ly/4vul3h3 https://sbpdiscovery.org/press/researchers-identify-new-genetic-disease-that-interferes-with-brain-development/16 Apr 2026 20:57 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3mjncevlnss2ahttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3mgq3s2pfgs2yNearly 40% of U.S. adults have metabolic syndrome, a condition that can lead to liver damage and fibrosis. A new study from Sanford Burnham Prebys highlights LARP6, an RNA-binding protein that helps drive fibrosis and may be a promising therapeutic target. https://sbpdiscovery.org/press/living-larp6-how-a-protein-plays-an-oversized-role-in-liver-fibrosis/10 Mar 2026 19:22 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3mgq3s2pfgs2yhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3mg43z5bkoc2xThank you to The San Diego Union-Tribune for helping share the story of Sanford Burnham Prebys as we mark 50 years of discovery and impact. We’re grateful for the spotlight on the people, science and community that have shaped our Institute since 1976. https://www.sandiegouniontribune.com/2026/02/27/a-novel-approach-sanford-burnham-prebys-celebrates-50-years-of-medical-exploration/02 Mar 2026 20:33 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3mg43z5bkoc2xhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3mepdnlyxrs2qAn international team including the Kaufman lab published in Nature.com showing that liver cell stress can both drive cancer and make tumors less resistant to immunotherapy. The findings may help physicians identify which patients are most likely to benefit from existing treatments.13 Feb 2026 01:19 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3mepdnlyxrs2qhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3mempgx4psk2xToday, on International Day of #WomenAndGirlsInScience, we gathered for the latest Women in Science Lecture Series. Thank you for the thoughtful and engaging conversation Cheryl Anderson, PhD, MPH, MS and Angela Liou, MD. Grateful to everyone who joined us. #InternationalDayOfWomenAndGirlsInScience12 Feb 2026 00:12 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3mempgx4psk2xhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3mdyqdmnlz22sSanford Burnham Prebys scientists published in @cp-cellreports.bsky.social showcasing a new approach for measuring the activity of enzymes linked to cell death and a more complicated picture where protein activation cannot always be presumed by protein production. https://sbpdiscovery.org/press/metallic-markers-make-direct-measurement-of-protein-activity-possible/04 Feb 2026 01:35 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3mdyqdmnlz22shttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3mdvlfc5mfs23Join us on February 11 for the next event in the Women in Science Lecture Series at Sanford Burnham Prebys, featuring a lecture and fireside chat that highlight the groundbreaking work and perspectives of women leaders in biomedical science. Must RSVP to attend: lnkd.in/gzkXQRrm02 Feb 2026 19:29 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3mdvlfc5mfs23https://bsky.app/profile/sbpdiscovery.bsky.social/post/3mdohnxbvgs2nAdvancing Together: 50 Years of Sanford Burnham Prebys - For 50 years, bold ideas, dedicated scientists, and a shared commitment to discovery have shaped who we are today. Join us as we celebrate this milestone year and look ahead to the next 50. https://youtu.be/Q4hNMzBq7N0?si=kASCvQ9T1dUDY-pJ30 Jan 2026 23:33 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3mdohnxbvgs2nhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3m5uhw4kfz22dNew research from Sanju Sinha, PhD, introduces DeepTarget, a tool that predicts both primary and secondary targets of cancer drugs. It could help repurpose existing medicines for more patients. https://sbpdiscovery.org/press/computational-deep-dive-surfaces-unexplored-world-of-cancer-drug-targets/18 Nov 2025 00:23 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3m5uhw4kfz22dhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3m52tgz3esj2jMeet Rouven Arnold, PhD, a postdoc in Peter Adams’ lab at Sanford Burnham Prebys. He studies how aging changes our cells—with the goal of preventing diseases like heart disease, cancer, and dementia. Learn what drives his work and his path into science. ➡️ https://bit.ly/47PtecX 07 Nov 2025 19:40 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3m52tgz3esj2jhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3m4qt3lz25s2bScientists at Sanford Burnham Prebys, the University of Minnesota and Duke University report in Nature that “biased modulators” can target GPCRs more precisely—expanding potential drug targets and reducing side effects. https://www.nature.com/articles/s41586-025-09643-203 Nov 2025 20:07 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3m4qt3lz25s2bhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3m3t2osjxrc2k“Once we find the players that drive disease, we can find drugs to help,” says Sanjeev Ranade, PhD. New study reveals a key protein linked to heart defects in Down syndrome. 🧬❤️ https://sbpdiscovery.org/press/hunting-for-the-chromosomal-genes-that-break-the-heart/23 Oct 2025 00:03 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3m3t2osjxrc2khttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3m3bhxhhnvk27🧬 Biomedical Sciences PhD Applications Now Open! Do you want to explore the science behind human health and disease? Our program is looking for curious and driven researchers ready to tackle the most pressing questions in biology and medicine. https://sbpdiscovery.org/education/graduate-school/16 Oct 2025 00:13 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3m3bhxhhnvk27https://bsky.app/profile/sbpdiscovery.bsky.social/post/3m2mp77vv3k2sWe’re pleased to announce that Paul Boutros, PhD, MBA, has been named the new director of the National Cancer Institute (NCI) designated cancer center at Sanford Burnham Prebys Medical Discovery Institute. Read all about it! https://sbpdiscovery.org/press/paul-boutros-named-cancer-center-director-at-sanford-burnham-prebys/07 Oct 2025 17:56 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3m2mp77vv3k2shttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3m2a3rrwdik22👏 Congratulations to Xueqin Sherine Sun, PhD, on receiving a $600,000 grant from the V Foundation for Cancer Research to study glioblastoma, one of the most common and deadly brain cancers. https://sbpdiscovery.org/xueqin-sun-awarded-600000-v-foundation-grant-to-study-one-of-the-most-common-and-deadly-brain-cancers/02 Oct 2025 17:37 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3m2a3rrwdik22https://bsky.app/profile/sbpdiscovery.bsky.social/post/3lzoau7dglk2nWhat connects survival, science + diabetes care? Adam Heller, PhD. At 92, this Holocaust survivor, scientist + engineer shares how his innovations changed how millions manage diabetes. 🎙️Hear his remarkable story in Episode 5 of the podcast. 👀On YouTube: https://youtu.be/TEhPlF29yl4?feature=shared25 Sep 2025 15:20 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lzoau7dglk2nhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lyye3agq3c2nToday, 62 National Cancer Institute (NCI)–Designated Cancer Centers issued a joint statement underscoring the importance of HPV vaccination. #HPVvaccine #HPVvax #EndHPVCancers16 Sep 2025 22:19 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lyye3agq3c2nhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lyhknjrdc22b🔬 New research from the @anideshpande.bsky.social Deshpande lab at Sanford Burnham Prebys. The study demonstrates how public genomic screening data can be used to uncover a new genetic vulnerability in synovial sarcoma. 👏 Shout out to Rema Iyer, PhD lead author of the manuscript.10 Sep 2025 06:01 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lyhknjrdc22bhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lwdiupmm4c2cFor decades, scientists thought MYOD was just a muscle-builder. But new research from Sanford Burnham Prebys shows this gene has a Jekyll-and-Hyde side—able to switch from activating muscle genes to silencing them. https://sbpdiscovery.org/press/muscles-master-regulator-moonlights-as-gene-silencer/14 Aug 2025 04:28 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lwdiupmm4c2chttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lvmf342dss2sProud to host six high school interns from the Preuss School for a hands-on research experience at Sanford Burnham Prebys. 👏 Thanks to Peggy & Peter Preuss and Debby & Wain Fishburn for making it possible! https://sbpdiscovery.org/preuss-school-interns-wrap-up-unforgettable-research-experience/04 Aug 2025 23:49 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lvmf342dss2shttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lvevg6ogas2lNew research from the Marth Lab: Most blood glycoproteins are easy to spot—but finding the rare ones is like searching for Waldo across every book. 🧠🧬 🔗 Read more: https://sbpdiscovery.org/press/signal-boost-uncovers-hundreds-of-hidden-binding-partners-for-blood-protein-receptor/ #Biomedicine #SanfordBurnhamPrebys #NatureCommunications #Science02 Aug 2025 00:20 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lvevg6ogas2lhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lv5ggebqhs2gMeet Meena Sudhakaran, PhD, a postdoc in the Kersten Lab at Sanford Burnham Prebys. She’s advancing cancer immunology to improve immunotherapy for breast cancer. Read more about her journey into science: https://sbpdiscovery.org/q-and-a-with-postdoctoral-researcher-meena-sudhakaran-phd-from-the-kersten-lab/ #CancerResearch #PostdocLife30 Jul 2025 01:03 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lv5ggebqhs2ghttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3luviicee2c2gA promising advance for pancreatic cancer published Cancer Cell: Blocking macropinocytosis reduces fibrosis around pancreatic tumors, improving immune cell access & boosting response to chemo & immunotherapy in mice. https://sbpdiscovery.org/press/reshaping-tumor-neighborhoods-to-give-treatments-a-boost/ @cosimocommisso.bsky.social @yijuan.bsky.social26 Jul 2025 21:19 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3luviicee2c2ghttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lu23drh7z22xBig congrats to grad students Aashna Lamba & Ashley Neil at @SBPdiscovery—named 2025 CIRM Predoctoral Fellows! 🌟 Lamba’s research could help hearts heal after injury ❤️ Neil is exploring brain inflammation in Alzheimer’s 🧠 #SanfordBurnhamPrebys #RegenerativeMedicine #CIRM #STEM15 Jul 2025 23:42 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lu23drh7z22xhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lswtdux3l22f📣 Welcome Michael Karin, Ph.D., to Sanford Burnham Prebys! He joins as director of the new Center for Metabolic and Liver Diseases and will continue his pioneering work on chronic inflammation and cancer. https://sbpdiscovery.org/press/leading-cancer-and-metabolic-disease-expert-michael-karin-joins-sanford-burnham-prebys/01 Jul 2025 23:15 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lswtdux3l22fhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lsfbxvoxok2pWhat if the key to major medical breakthroughs is already sitting in clinical databases—just waiting to be unlocked? Sanford Burnham Prebys CEO David Brenner shares why tapping into electronic health records could transform research and care. Read more: https://www.sandiegouniontribune.com/2025/06/23/opinion-health-database-could-provide-key-insights-to-improve-care/24 Jun 2025 23:49 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lsfbxvoxok2phttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lquljuxkgu2rCheers to the newest grads of the Sanford Burnham Prebys Graduate School of Biomedical Sciences! 🎓🔬♥️ Their hard work, perseverance, and curiosity reflect the spirit of our graduate program's motto: “Knowledge is the power to heal.” Congrats to these rising scientists. More: https://bit.ly/3HFmyEB05 Jun 2025 15:00 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lquljuxkgu2rhttps://bsky.app/profile/sbpdiscovery.bsky.social/post/3lqslv3zysn2v🧠 Could HIV drugs help lower #Alzheimer’s risk? New research from Sanford Burnham Prebys, led by Jerold Chun, MD, PhD, found that patients taking #HIV drugs blocking #reversetranscriptase had fewer cases of Alzheimer’s—pointing to a potential drug target. More: https://bit.ly/4kuxvHU04 Jun 2025 20:01 +0000at://did:plc:7ac7nmj6hecxmfqk3a4so4b5/app.bsky.feed.post/3lqslv3zysn2v