A BlueSky feed for the blog http://covalentmodifiers.blogspot.com. Discusses the covalent modification of proteins, particularly with regards to inhibitors.https://bsky.app/profile/covalentmod.bsky.socialhttps://bsky.app/profile/covalentmod.bsky.social/post/3myzgggzwfr2aNinhydrin as a Covalent Warhead for Chemical Proteomic-Enabled Discovery and Selective Engagement of Reactive Arginines https://covalentmodifiers.blogspot.com/2026/10/ninhydrin-as-covalent-warhead-for.html29 Oct 2026 14:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3myzgggzwfr2ahttps://bsky.app/profile/covalentmod.bsky.social/post/3myzgggwxhd2iOvercoming EGFR Resistance by Monovalent and Bident Inhibitors Targeting Cys775 https://covalentmodifiers.blogspot.com/2026/10/overcoming-egfr-resistance-by.html29 Oct 2026 14:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3myzgggwxhd2ihttps://bsky.app/profile/covalentmod.bsky.social/post/3myjisjswts2kCharacterization of F-30 as an FGFR2/4-selective covalent inhibitor with activity against clinically relevant mutations https://covalentmodifiers.blogspot.com/2026/10/characterization-of-f-30-as-fgfr24.html23 Oct 2026 06:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3myjisjswts2khttps://bsky.app/profile/covalentmod.bsky.social/post/3mxyqefbbo72zCovalent-Allosteric Akt Inhibitors: Targeting Akt3 through Molecular Hybridization and Expanding the Isoform-Selective Toolbox https://covalentmodifiers.blogspot.com/2026/10/covalent-allosteric-akt-inhibitors.html16 Oct 2026 14:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mxyqefbbo72zhttps://bsky.app/profile/covalentmod.bsky.social/post/3mxmi3nl7rc2wSub-stoichiometric degradation is dispensable for potent PROTACs as demonstrated by irreversible covalent BTK degraders https://covalentmodifiers.blogspot.com/2026/10/sub-stoichiometric-degradation-is.html11 Oct 2026 17:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mxmi3nl7rc2whttps://bsky.app/profile/covalentmod.bsky.social/post/3mxemmzopsn23Sulfonyl-Imidazopyridines Decouple Reactivity from Stability for Ligandability Mapping and Covalent Inhibitor Discovery https://covalentmodifiers.blogspot.com/2026/10/sulfonyl-imidazopyridines-decouple.html08 Oct 2026 14:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mxemmzopsn23https://bsky.app/profile/covalentmod.bsky.social/post/3mx2e2rhest2kβ-d-Arabinofuranose-configured Cyclitol Aziridines as Selective, Brain-penetrant Covalent GBA2 Inhibitors https://covalentmodifiers.blogspot.com/2026/10/d-arabinofuranose-configured-cyclitol.html04 Oct 2026 12:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mx2e2rhest2khttps://bsky.app/profile/covalentmod.bsky.social/post/3mwvn6sez6q2hStructure-Guided Design of a Brain-Penetrant Covalent Inhibitor of Human Butyrylcholinesterase with In Vivo Procognitive Efficacy https://covalentmodifiers.blogspot.com/2026/10/structure-guided-design-of-brain.html02 Oct 2026 15:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mwvn6sez6q2hhttps://bsky.app/profile/covalentmod.bsky.social/post/3mw4luzrreh2sFragment-Based Covalent Targeting of Lysines at the Allosteric Latch Site of SHP2. https://covalentmodifiers.blogspot.com/2026/09/fragment-based-covalent-targeting-of.html22 Sep 2026 16:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mw4luzrreh2shttps://bsky.app/profile/covalentmod.bsky.social/post/3mvhgmmu6xr2xDual-Site Covalent Targeting Enables BD2-Selective BET Inhibition With Potent Antitumor Activity in Mice https://covalentmodifiers.blogspot.com/2026/09/dual-site-covalent-targeting-enables.html14 Sep 2026 06:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mvhgmmu6xr2xhttps://bsky.app/profile/covalentmod.bsky.social/post/3mvhdbffoib2xIsoform-Selective Targeting of Akt Through Covalent Allosteric Inhibition https://covalentmodifiers.blogspot.com/2026/09/isoform-selective-targeting-of-akt.html14 Sep 2026 05:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mvhdbffoib2xhttps://bsky.app/profile/covalentmod.bsky.social/post/3muf2vzvdh422An enantioselective covalent inhibitor of BAX confers cytoprotection in vivo https://covalentmodifiers.blogspot.com/2026/08/an-enantioselective-covalent-inhibitor.html31 Aug 2026 14:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3muf2vzvdh422https://bsky.app/profile/covalentmod.bsky.social/post/3mudzf5gacn26Enhancing De Novo Designed Peptides and Proteins via Irreversible Covalent Isoquinolinium Capture https://covalentmodifiers.blogspot.com/2026/08/enhancing-de-novo-designed-peptides-and.html31 Aug 2026 04:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mudzf5gacn26https://bsky.app/profile/covalentmod.bsky.social/post/3mucuixoep32cSulfonyl-Imidazopyridines Decouple Reactivity from Stability for Ligandability Mapping and Covalent Inhibitor Discovery https://covalentmodifiers.blogspot.com/2026/08/sulfonyl-imidazopyridines-decouple_0433173794.html30 Aug 2026 17:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mucuixoep32chttps://bsky.app/profile/covalentmod.bsky.social/post/3mtx4yp2ang2fDevelopment of Covalent Inhibitors of Chikungunya Virus nsP2 Cysteine Protease Enabled by Direct-to-Biology Synthesis and Screening D https://covalentmodifiers.blogspot.com/2026/08/development-of-covalent-inhibitors-of.html26 Aug 2026 01:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mtx4yp2ang2fhttps://bsky.app/profile/covalentmod.bsky.social/post/3mts7g5if7324Covalent allosteric inhibition of AARS1 lactyltransferase https://covalentmodifiers.blogspot.com/2026/08/covalent-allosteric-inhibition-of-aars1.html24 Aug 2026 02:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mts7g5if7324https://bsky.app/profile/covalentmod.bsky.social/post/3mtp2tiz3io2aSulfonyl-Imidazopyridines Decouple Reactivity from Stability for Ligandability Mapping and Covalent Inhibitor Discovery https://covalentmodifiers.blogspot.com/2026/08/sulfonyl-imidazopyridines-decouple.html22 Aug 2026 20:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mtp2tiz3io2ahttps://bsky.app/profile/covalentmod.bsky.social/post/3mt6cfdrd4n2eLate-stage functionalization with strain-release warheads enables tunable covalent inhibition. https://covalentmodifiers.blogspot.com/2026/08/late-stage-functionalization-with.html16 Aug 2026 04:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mt6cfdrd4n2ehttps://bsky.app/profile/covalentmod.bsky.social/post/3msyjyiivb32vDiscovery and Optimization of a WRN Helicase Inhibitor Series through Structure-Guided Drug Design from a Covalent Fragment Binding Insight https://covalentmodifiers.blogspot.com/2026/08/discovery-and-optimization-of-wrn.html13 Aug 2026 21:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3msyjyiivb32vhttps://bsky.app/profile/covalentmod.bsky.social/post/3msootfezlf2pDiscovery of a covalent FGFR2-selective inhibitor overcoming clinically-acquired resistance mutations https://covalentmodifiers.blogspot.com/2026/08/discovery-of-covalent-fgfr2-selective.html09 Aug 2026 23:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3msootfezlf2phttps://bsky.app/profile/covalentmod.bsky.social/post/3msg3vqdnzp2iA covalent PFKL activator suppresses tumor growth https://covalentmodifiers.blogspot.com/2026/08/a-covalent-pfkl-activator-suppresses.html06 Aug 2026 13:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3msg3vqdnzp2ihttps://bsky.app/profile/covalentmod.bsky.social/post/3mromv63k4i2wLate-stage functionalization with strain-release warheads enables tunable covalent inhibition https://covalentmodifiers.blogspot.com/2026/07/late-stage-functionalization-with.html28 Jul 2026 05:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mromv63k4i2whttps://bsky.app/profile/covalentmod.bsky.social/post/3mrfzxitrsd2uPeptidic Phosphonates as Irreversible Covalent Inhibitors of Plasmodium falciparum Serine Protease PfSUB1. https://covalentmodifiers.blogspot.com/2026/07/peptidic-phosphonates-as-irreversible.html24 Jul 2026 19:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mrfzxitrsd2uhttps://bsky.app/profile/covalentmod.bsky.social/post/3mrd43g4rma2yCHARMM-GUI Covalent Ligand Docker as a Web-based Molecular Docking Platform for Covalent Ligands https://covalentmodifiers.blogspot.com/2026/07/charmm-gui-covalent-ligand-docker-as.html23 Jul 2026 15:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mrd43g4rma2yhttps://bsky.app/profile/covalentmod.bsky.social/post/3mraevwnfe425Covalent remodeling of CRBN creates a non-canonical neosubstrate interface with NTAQ1 https://covalentmodifiers.blogspot.com/2026/07/covalent-remodeling-of-crbn-creates-non.html22 Jul 2026 13:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mraevwnfe425https://bsky.app/profile/covalentmod.bsky.social/post/3mr2ch6qekc2yA covalent irreversible inhibitor binds in two mutually exclusive conformations to the active-site cysteine residue of human aldehyde dehydrogenase 1A3 https://covalentmodifiers.blogspot.com/2026/07/a-covalent-irreversible-inhibitor-binds.html20 Jul 2026 03:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mr2ch6qekc2yhttps://bsky.app/profile/covalentmod.bsky.social/post/3mquqqw46qr2yA covalent inhibitor targeting Cys-349 of LIMK1 confers selectivity over LIMK2 https://covalentmodifiers.blogspot.com/2026/07/a-covalent-inhibitor-targeting-cys-349.html17 Jul 2026 22:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mquqqw46qr2yhttps://bsky.app/profile/covalentmod.bsky.social/post/3mqnthv3vam24Machine learning-guided discovery of covalent sortase A inhibitors targeting MRSA virulence https://covalentmodifiers.blogspot.com/2026/07/machine-learning-guided-discovery-of.html15 Jul 2026 04:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mqnthv3vam24https://bsky.app/profile/covalentmod.bsky.social/post/3mnqs7tfgwb2kA chemoproteomic atlas of the human purine interactome for regioselective ligand discovery https://covalentmodifiers.blogspot.com/2026/06/a-chemoproteomic-atlas-of-human-purine.html08 Jun 2026 04:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mnqs7tfgwb2khttps://bsky.app/profile/covalentmod.bsky.social/post/3mmkr654h4z2wCharacterization of the Second-Generation Covalent Fragment Library (CovLib Gen2): Thiol Reactivity Profiling and p53-Y220C Rescue https://covalentmodifiers.blogspot.com/2026/05/characterization-of-second-generation.html24 May 2026 01:00 +0000at://did:plc:7h2tk3fyncbpmsvwlrpv5m6a/app.bsky.feed.post/3mmkr654h4z2w