Stem Cell Metabolism lab. We use iPSCs and brain organoids to search for cures for rare mitochondrial neurological diseases. Professor at the Medical Faculty of Heinrich Heine University, Düsseldorf. Editor-in-Chief of Stem Cell Research journal. He/him.https://bsky.app/profile/aleprigio.bsky.socialhttps://bsky.app/profile/aleprigio.bsky.social/post/3mpmiip7njs2fGrateful to @mitoworld.bsky.social for highlighting our work and the insightful interview! [contains quote post or other embedded content]01 Jul 2026 21:45 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3mpmiip7njs2fhttps://bsky.app/profile/aleprigio.bsky.social/post/3mnig2smdrk2dThank you very much @mitoworld.bsky.social for highlighting our work and the upcoming trial! We plan to start recruiting individuals with MT-ATP6 variants later this year. [contains quote post or other embedded content]04 Jun 2026 20:01 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3mnig2smdrk2dhttps://bsky.app/profile/aleprigio.bsky.social/post/3mmsv7kxeik2vFantastic work from @andrearossilab.bsky.social Rossi lab on the development of @cleanfinder.bsky.social for nuclear and mitochondrial genome editing application. Greatful that my lab have contributed! [contains quote post or other embedded content]27 May 2026 06:33 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3mmsv7kxeik2vhttps://bsky.app/profile/aleprigio.bsky.social/post/3ml7qbwlkoc2pIn the midst of bad news in the word, it was amazing and humbling to see our recent discovery of sildenafil in Leigh syndrome in @cp-cell.bsky.social highlighted among five inspiring uplifting stories in @nature.com https://www.nature.com/articles/d41586-026-01290-506 May 2026 22:19 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3ml7qbwlkoc2phttps://bsky.app/profile/aleprigio.bsky.social/post/3ml52iwisms2vOur spotlight article is out in Cell Metabolism highlighting the exciting publication by Du et al in Cell showing the effectiveness of mitochondrial transplantation @cellpress.bsky.social https://authors.elsevier.com/a/1n2ge5WXUleMCV05 May 2026 20:44 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3ml52iwisms2vhttps://bsky.app/profile/aleprigio.bsky.social/post/3mjwye4ymss2jThanks Leo for sharing! 🙏 [contains quote post or other embedded content]20 Apr 2026 17:25 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3mjwye4ymss2jhttps://bsky.app/profile/aleprigio.bsky.social/post/3mjwydcnt3k2jSuper excited to share our latest work! In collaboration with Antonio del Sol, we show that brain organoids coupled with deep learning screening allow uncovering new repurposable drugs for the incurable mitochondrial disease Leigh syndrome. https://www.nature.com/articles/s41467-026-71391-220 Apr 2026 17:24 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3mjwydcnt3k2jhttps://bsky.app/profile/aleprigio.bsky.social/post/3mgt2waynuc2w#NotTheCover We proposed this image for our paper out now in CELL @cellpress.bsky.social It depicts sildenafil treatment like a wave displacing the visual noise associated with mitochondrial dysfunction. Fantastic work from Emma Vidal at DrawImpacts!11 Mar 2026 23:44 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3mgt2waynuc2whttps://bsky.app/profile/aleprigio.bsky.social/post/3mgsnvubees2iInsightful commentary in @science.org on our paper out now in @cellpress.bsky.social. Thank you very much to Catherine Offord for writing this piece and to @vgamalab.bsky.social for the supportive words! https://www.science.org/content/article/viagra-compound-may-hold-promise-treating-fatal-genetic-disease11 Mar 2026 19:51 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3mgsnvubees2ihttps://bsky.app/profile/aleprigio.bsky.social/post/3mgsnif2dzc2iOur collaborative work is out now in CELL @cellpress.bsky.social We sugggest sildenafil as a repurposable drug for mitochondrial disease. A clinical trial is planned to start later this year. Thanks to collaborators, funders, and patient organizations! https://www.sciencedirect.com/science/article/pii/S009286742600173X11 Mar 2026 19:44 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3mgsnif2dzc2ihttps://bsky.app/profile/aleprigio.bsky.social/post/3m66cjpmhkc2pThanks for the highlight @dmmjournal.bsky.social [contains quote post or other embedded content]21 Nov 2025 22:13 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3m66cjpmhkc2phttps://bsky.app/profile/aleprigio.bsky.social/post/3m4dfexg5722kOur latest perspective is out in Dis Model Mech (@biologist.bsky.social)! We discuss how brain organoids highlight the impact of Huntington's disease on brain development. We suggest takling mitochondrial fitness early on a as a potential treatment strategy. https://doi.org/10.1242/dmm.05251029 Oct 2025 11:57 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3m4dfexg5722khttps://bsky.app/profile/aleprigio.bsky.social/post/3lunivtamhc2jOur latest review is out in STEM CELLS! We discuss the role of mitochondria in neuronal branching and how iPSC models in 2D and 3D can be used dissect the impact of neuronal branching defects in mitochondrial disorders. https://academic.oup.com/stmcls/advance-article/doi/10.1093/stmcls/sxaf050/8203079?login=false23 Jul 2025 17:05 +0000at://did:plc:7ncnnocsll6w7upsytimetqb/app.bsky.feed.post/3lunivtamhc2j