Prism is building the full stack of technologies and algorithms necessary to make protein motion measurable, actionable, and predictable. Learn more at prismscience.orghttps://bsky.app/profile/prismscienceorg.bsky.socialhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mvsycw6pzi2rMicroseeding made a big difference in Katie Lu’s Mac1 crystallization screens: 8 potential hits became 54. She’s using those results to optimize crystals for experiments asking how the crystal environment affects diffuse scattering. https://prismscience.org/research/katie-lu-summer-202618 Sep 2026 20:16 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mvsycw6pzi2rhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3muziqgeqbu2rWe have not yet tapped the full potential of cryoEM. The method revolutionized structural bio with atomic-level detail, but has largely focused on proteins’ common lowest-energy states. With enough samples, cryoEM sees a broader energy landscape: It can capture *rare* states.08 Sep 2026 17:00 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3muziqgeqbu2rhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3muz3idspis2eWe need new ways to understand disease & design drugs. Protein motion holds the answer.08 Sep 2026 13:03 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3muz3idspis2ehttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mupayaixg22yDiffuse scattering is hard to compare quantitatively across experiments, let alone across synchrotrons. A new DiffUSE Project update shows diffuse maps reproducing across CHESS and ALS. Read the project update: https://diffuse.science/posts/reproducibility-stack/04 Sep 2026 15:15 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mupayaixg22yhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mun5uawomv2lDiffuse scattering can encode correlated protein motions, but standard pipelines often discard it as background. mdx2 is an open-source Python toolkit for carrying that signal through processing. Read @meisborg.bsky.social's overview and try mdx2: diffuse.science/posts/mdx2/ https://diffuse.science/posts/mdx2/03 Sep 2026 19:14 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mun5uawomv2lhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3muhx7zpj5y2wSame mission, but an expanded vision for revolutionizing structural biology to better capture protein motion. Launching September 8.01 Sep 2026 17:32 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3muhx7zpj5y2whttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mu5u6b6cp22pCheck out our latest! 🌊 [contains quote post or other embedded content]28 Aug 2026 17:10 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mu5u6b6cp22phttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mtmik7qb342iDiffUSE is rebuilding GOODVIBES, a forward model for lattice vibrations in diffuse scattering, in fully open-source Python that handles any space group or unit cell. Stephen Thornton posts the progress and open questions. https://diffuse.science/posts/goodvibes/ #openscience21 Aug 2026 19:27 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mtmik7qb342ihttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mst6zhywfb2jMost structures in the PDB report one set of coordinates. The experimental data behind them, in both X-ray crystallography and cryo-EM, is produced by an ensemble. New work recovers that hidden signal at scale in over 60,000 structures. https://thestacks.org/publications/qfit-at-scale11 Aug 2026 18:00 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mst6zhywfb2jhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3msqfc7wume25New in BANDICOOT: color each altloc a distinct hue, so you see heterogeneity while you build. Each added alternate conformation is auto hue-shifted from the last; remove them all and the residue returns to bulk color. Configurable and open source! https://diffuse.science/post/bandicoot-PRISM-blog-2/ #compbio10 Aug 2026 15:14 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3msqfc7wume25https://bsky.app/profile/prismscienceorg.bsky.social/post/3mrqxyenjyu25An mmCIF file can say a residue has two alternate conformations and how often each appears. It cannot say which alternates occur together in the same copy. A draft proposal for recording that correlation, plus a tool to inspect it: https://diffuse.science/posts/mmcif-browser/29 Jul 2026 03:24 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mrqxyenjyu25https://bsky.app/profile/prismscienceorg.bsky.social/post/3mrnjzeczvl2iIn our latest blog, @fraserlab.com graduate student Taylor Womack discusses his roadmap before the results: how he plans to separate lattice vibrations from internal protein motion, which open tools he is using, and which parts are still unresolved. Feedback welcome. https://diffuse.science/posts/taylor-roadmap/ https://xtraj.py27 Jul 2026 18:36 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mrnjzeczvl2ihttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mr7ixsy5hm2oNew TTPD episode discusses two bioRxiv preprints, revisits the Bethesda Declaration one year on, and public pushback to the OMB funding rule. Plus: where blogs end and peer review begins. diffuse.science/posts/TTPD-16/ #StructuralBiology #Biophysics #OpenScience22 Jul 2026 04:40 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mr7ixsy5hm2ohttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mr7epvywxo2pBandicoot reengineers Coot 0.9 for macOS Tahoe: toolbars rebuilt, UI moved from Python 2 to C++, atom picking and labels reworked. Now with built-in pandda.inspect for examining partial-occupancy and alt conformations. https://diffuse.science/post/bandicoot/22 Jul 2026 03:24 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mr7epvywxo2phttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mqou7eof562bWhy do protein-function AI models look great on benchmarks but disappoint in practice? Often "leakage": proteins meant for testing slip into training data over time, inflating scores. PLUG is a tool to build cleaner training sets. Read Clay's work: https://diffuse.science/post/plug-benchmark/ #proteinML15 Jul 2026 13:45 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mqou7eof562bhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mplzy6wunh2qUnlocking protein dynamics requires infrastructure we all can access. ICYMI: all of our software packages live on GitHub, updated in the open: github.com/diff-use https://github.com/diff-use01 Jul 2026 17:26 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mplzy6wunh2qhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mpj2ryurbv2iOpen science is useful science. One effort we are developing are logbooks where we share research as it happens: what works, what doesn't, what we've learned. Led by DiffUSE Scientist Steve Meisburger (@meisborg.bsky.social). See the latest: https://diffuse.science/logbook/beamtime/20260622-chess/ #OpenScience30 Jun 2026 13:02 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mpj2ryurbv2ihttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mpgxk34rjz24What's happening in protein dynamics research right now? Jaime & Stephanie break down NIH policy changes, preprints & the conformational ensembles conference. New episode up: diffuse.science/posts/TTPD-15/ #StructuralBiology29 Jun 2026 16:59 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mpgxk34rjz24https://bsky.app/profile/prismscienceorg.bsky.social/post/3moj7ytapx62bBulk solvent fills ~half a protein crystal. Modeling this is required for a good fit to experimental data. How best to model this remains an open question. New from diffUSE: a Phenix patch to supply your own solvent map (MD, 3D-RISM, EDEN, neural nets). Read more here: https://thestacks.org/publications/method-bulksolvent/17 Jun 2026 21:10 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3moj7ytapx62bhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3modjrde7ev2bWe share science at The DiffUSE Project in a few ways: blogs to contextualize motivation and intuition, scholarly outputs for methods, data, code, and a citable DOI. All open and shared rapidly for the best science. Our latest: https://doi.org/10.82153/jkxj-tw0815 Jun 2026 14:49 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3modjrde7ev2bhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mnufgxi6fa2mWe present sampleworks, an open, modular platform for generating and evaluating biomolecular conformational ensembles from structure predictors guided by experimental data https://doi.org/10.82153/jkxj-tw08.09 Jun 2026 14:22 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mnufgxi6fa2mhttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mne7vixhgd2gWant to shape the future of structural biology? We are seeking a Project Manager to help lead the DiffUSE Project, guiding ML researchers, computational scientists, national labs, and university partners. Apply: buff.ly/gZlj9AP #StructuralBiology #MachineLearning #Hiring #AcademicSky https://jobs.ashbyhq.com/astera/d9afacb0-84a3-42ba-b348-50f312cb149903 Jun 2026 04:00 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mne7vixhgd2ghttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mmux2k6h4326The DiffUSE Project wants examples where structural heterogeneity matters but cannot be encoded in PDBx/mmCIF. X-ray, cryo-EM, time-resolved, multi-map, or fragment screening data welcome. Submit yours: diffuse.science/submit/ https://diffuse.science/submit/28 May 2026 02:12 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mmux2k6h4326https://bsky.app/profile/prismscienceorg.bsky.social/post/3mlqqa5cwex2oICYMI: The latest Tortured Proteins Department episode. @stephanieaw.bsky.social and @fraserlab.com on: NIH strategic plan comments (due 5/26), AI lab guidelines, two new cryo-EM preprints, training scientists for what's next diffuse.science/posts/TTPD-14/13 May 2026 16:34 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mlqqa5cwex2ohttps://bsky.app/profile/prismscienceorg.bsky.social/post/3mj2zfmkiis2a🎉🎉🎉 [contains quote post or other embedded content]09 Apr 2026 14:29 +0000at://did:plc:abplwuceoh4mfclxgcdg6aj4/app.bsky.feed.post/3mj2zfmkiis2a