PhD student in structural biology with @greening.bsky.social and @knottrna.bsky.social at Monash Uni. (he/him) Interested in hydrogenases, evolution, protein design. 💻 https://www.jameslingford.com/https://bsky.app/profile/jameslingford.bsky.socialhttps://bsky.app/profile/jameslingford.bsky.social/post/3mjiql4w6g22xAmazing paper. A megadalton enzyme complex that: - combines both electron bifurcation AND confurcation steps - has a new type of iron-sulfur cluster - a new kind of weird electron transfer path - super charges electrons to reduce aromatic rings - also powers respiration 😳 [contains quote post or other embedded content]15 Apr 2026 01:28 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mjiql4w6g22xhttps://bsky.app/profile/jameslingford.bsky.social/post/3mi3ik44fs22aFound out today that @kyclark.bsky.social has made their great 'Mastering Python for Bioinformatics' book into a YouTube series. https://youtube.com/playlist?list=PLhOuww6rJJNMS6mZ3cUOi2qyDmKie_PY1&si=yd5QvpWCK6LmMSDO28 Mar 2026 01:34 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mi3ik44fs22ahttps://bsky.app/profile/jameslingford.bsky.social/post/3mfssqb7uc22uA minimal PyTorch re-implementation of AlphaFold2 https://github.com/ChrisHayduk/minAlphaFold2 We need more stuff like this. The incentive is to always be making the new groundbreaking tool, while maintenance + improvement of "old" tools gets left behind. But there is still heaps to be gained in "old" tools27 Feb 2026 03:53 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mfssqb7uc22uhttps://bsky.app/profile/jameslingford.bsky.social/post/3mfryrkrcp222Aerobic syngas conversion: opportunities, challenges, and solutions https://www.sciencedirect.com/science/article/pii/S136952742600019626 Feb 2026 20:08 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mfryrkrcp222https://bsky.app/profile/jameslingford.bsky.social/post/3mfq5kwkmks26Any paper that quotes Italo Calvino is an instant 10/10 in my book 'An Interpretation, Survey, and Outlook of Microbial Macroecology' by @shoestrapped.bsky.social https://ecoevorxiv.org/repository/view/11557/26 Feb 2026 02:28 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mfq5kwkmks26https://bsky.app/profile/jameslingford.bsky.social/post/3mfkwnzoozc2pInsects were my first scientific love (before I knew about proteins). So I love hearing about some new weird insect "Temnothorax kinomurai is the first ant species known to lack both workers and males and to consist exclusively of queens" https://doi.org/10.1016/j.cub.2025.11.080 @currentbiology.bsky.social24 Feb 2026 00:42 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mfkwnzoozc2phttps://bsky.app/profile/jameslingford.bsky.social/post/3mfiq6hau6c2gUnderstanding how enzymes work: the journey to ensemble–function studies https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.70456 This is an exceptionally well written review on how enzymes work. Rather than the structure-function relationship, Herschlag & Du analyse the ensemble-function relationship23 Feb 2026 03:40 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mfiq6hau6c2ghttps://bsky.app/profile/jameslingford.bsky.social/post/3mfftihssp22fStructural ontogeny of protein-protein interactions: https://www.science.org/doi/10.1126/science.adx6931 Fundamental work on how PPIs (co)evolve, combining directed evolution and machine learning to reveal the role of chance and contingency.22 Feb 2026 00:01 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mfftihssp22fhttps://bsky.app/profile/jameslingford.bsky.social/post/3mfd37yftbk22Asgard archaeal origin of microtubules: https://www.biorxiv.org/content/10.64898/2026.02.15.705738v120 Feb 2026 21:42 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mfd37yftbk22https://bsky.app/profile/jameslingford.bsky.social/post/3mfbdopsu4k2oI present this extremely niche meme for the hydrogenase community20 Feb 2026 05:08 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mfbdopsu4k2ohttps://bsky.app/profile/jameslingford.bsky.social/post/3mfarxkop522p"GenAI increases output and helps programmers expand into new domains—but only for senior- level developers. Early-career developers, despite being the most enthusiastic adopters, see no measurable gains" https://www.science.org/doi/10.1126/science.adz931119 Feb 2026 23:51 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mfarxkop522phttps://bsky.app/profile/jameslingford.bsky.social/post/3mf6c3f2qjs2mOur work is published today: ‘Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor’. This was a huge effort lead by @katyappler.bsky.social. Extremely grateful to have been a part of this amazing project! 😊🦠🧬 Links: https://www.nature.com/articles/s41586-026-10128-z https://www.nature.com/articles/s41586-026-10128-z.epdf?sharing_token=-FNi9FRC4TyXs9khQbKK-9RgN0jAjWel9jnR3ZoTv0O9EJ8Oq5RpOqLJwfn_LSc01nx3kE6XY6v_NkYWsnOlVygxvLcjDvanzvi5zxLB38MpAa7RdEWkr_UzCPSLvkTRCLdU2H8VpELCWQU8MCob9CEne4t_FoojL_P80SRGMD4%3D19 Feb 2026 00:01 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mf6c3f2qjs2mhttps://bsky.app/profile/jameslingford.bsky.social/post/3mf52btnw4c2fKeep hearing hype around vibe coding and how its going to replace all coding very soon. So I look into pro-vibe coding communities on reddit. They all say you have to hold the hand of the AI at every step of the way and have very long but specific prompts, otherwise the AI makes a mess... 1/218 Feb 2026 12:09 +0000at://did:plc:arnopirhmzvadspoff2l3235/app.bsky.feed.post/3mf52btnw4c2f