Associate Vice President for Research. Bighley Chair and Professor of Pharmaceutical Sciences. Views are my own. Science & Technology, Iowa City, IA salem.lab.uiowa.edu Joined 11/23/24https://bsky.app/profile/aliasgersalem.bsky.socialhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lqxhgcqsk226Iowa Now: UI professors Aliasger Salem and Mark Greiner receive new 5-year $2.85 million NIH grant to help prevent vision loss from corneal disease. https://now.uiowa.edu/news/2025/06/ui-professors-receive-grant-help-prevent-vision-loss-corneal-disease06 Jun 2025 18:24 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lqxhgcqsk226https://bsky.app/profile/aliasgersalem.bsky.social/post/3lqxgyn4jt226Attention UIowa Summer Undergrad Researchers: On June 18th at 1:30pm in C44-A General Hospital, the undergraduate B.E.S.T. Researcher summer program will hold a panel discussion with myself, Ned Bowden, and Sarah Sapouckey on intellectual property and starting a company.06 Jun 2025 18:17 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lqxgyn4jt226https://bsky.app/profile/aliasgersalem.bsky.social/post/3lpg5r6kn422zJust published: Cyclodextrin-Based Inclusion Complexes Improve the In Vitro Solubility and Pharmacokinetics of Ivacaftor Following Oral Administration in Mice. Nakhla et al. Link to article: rdcu.be/emoRw18 May 2025 03:51 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lpg5r6kn422zhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3loelxqpeic2kThe American Association of Pharmaceutical Scientists (AAPS) | @aapscomms National Biotechnology Conference in Boston #NBC2025 has started. The opening talk is from Dr. Nikhil Munshi, Professor of Medicine at Harvard University and Director at Dana-Farber Cancer Institute.04 May 2025 19:35 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3loelxqpeic2khttps://bsky.app/profile/aliasgersalem.bsky.social/post/3locf5drztk2eJust published: In situ treatment with a TLR9 agonist virus-like particle to promote immune responses against oral epithelial dysplasia progression. Xu et al. https://link.springer.com/article/10.1007/s00262-025-04023-103 May 2025 22:27 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3locf5drztk2ehttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lo36kdl5ts2bI’m delighted to share that our company S5G Therapeutics won the $50,000 first prize tonight in this year’s JPEC Innovation Challenge! We look forward to moving our therapy for surface ocular diseases into the clinic as our planned next steps.01 May 2025 01:41 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lo36kdl5ts2bhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3ln7hxit63k2qNow published: The Heartland Environmental Alliance for Resilience & Transformation (HEART) – Improving the Lives and Livelihoods of People Across the Heartland Through Environmental Change Resilience Research, Education, and Outreach. https://doi.org/10.1029/2024CN00027120 Apr 2025 01:14 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3ln7hxit63k2qhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3ln7hrp2hmk2qThe National Academy of Inventors has ranked the University of Iowa in the top 100 U.S. Universities granted U.S. utility patents through procurement of United States patents to protect the intellectual property of their accomplishments in innovation and invention.20 Apr 2025 01:11 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3ln7hrp2hmk2qhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lmlqxd4xxc2uThe annual 2025 Society For Biomaterials meeting has been excellent. Mohammad Alnatour, Esraa Mohamed, Apurva Dusane, Ramkrishna Sen and Adam Salem all gave outstanding presentations. #SFB202512 Apr 2025 05:02 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lmlqxd4xxc2uhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lmkshc7xuc2yThe University of Iowa welcomes new members Drs Sandeep Laroia, Robert Philibert, Suresh Raghavan, Kristina Thiel, Molly Kucera and Maleeha Naseem to the local University of Iowa National Academy of Inventors chapter. Congratulations! https://research.uiowa.edu/news/2025/04/ui-welcomes-new-member-class-nai-chapter11 Apr 2025 19:56 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lmkshc7xuc2yhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lmfffcjuoc2aCollaborative paper with Mark Greiner in press: Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy. Hartness et al. Investigative Ophthalmology & Visual Science. https://iovs.arvojournals.org/article.aspx?articleid=280278209 Apr 2025 16:19 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lmfffcjuoc2ahttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lmffe72zak2aCollaborative paper with Mark Greiner in press: Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy. Hartness et al. Investigative Ophthalmology & Visual Science. https://iovs.arvojournals.org/article.aspx?articleid=280278209 Apr 2025 16:19 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lmffe72zak2ahttps://bsky.app/profile/aliasgersalem.bsky.social/post/3llwbkdhkjs2zI am delighted to share that I have received the 2025 Regents Award for Faculty Excellence. The award provides a state-wide forum in which the excellence of faculty members is recognized and shared with colleagues from other Regent institutions. https://now.uiowa.edu/news/2025/04/6-faculty-honored-2025-regents-award-faculty-excellence03 Apr 2025 16:01 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3llwbkdhkjs2zhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lli53jthu22rMy visit to Virginia Commonwealth University School of Pharmacy today was excellent. The visit was also an excellent opportunity for our new $13 million VCU-Iowa program project team (including Drs Sarkar and Fisher) focused on treating liver cancer to connect and plan next steps.29 Mar 2025 01:03 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lli53jthu22rhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3llaexkjtqs2oTomorrow is One Day for Iowa, and University of Iowa Core Equipment Facilities needs you! Give to University of Iowa @UIowaResearch Core Equipment Facilities 1dayforiowa.org/VPR25 https://1dayforiowa.org/VPR2525 Mar 2025 23:03 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3llaexkjtqs2ohttps://bsky.app/profile/aliasgersalem.bsky.social/post/3llad7gx33k2oIm looking forward to presenting my research at VCU School of Pharmacy this Friday, (03/28). My favorite invitations to speak are consistently the ones that come from the students and I'm grateful to the AAPS VCU student chapter for planning the visit.25 Mar 2025 22:32 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3llad7gx33k2ohttps://bsky.app/profile/aliasgersalem.bsky.social/post/3llacexq5bs2oRead about recent work on how circulating tumor DNA in blood samples can predict which colorectal cancer patients should and should not get chemotherapy from my good friend, colleague and collaborator Dr. Pashtoon Kasi. https://www.cancer.gov/news-events/cancer-currents-blog/2024/colorectal-cancer-ctdna-may-guide-adjuvant-therapy25 Mar 2025 22:17 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3llacexq5bs2ohttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lkzek7p7622sCollaborative paper in press: Astrocyte elevated gene-1 (AEG-1) in myeloid cells is a key driver for the development of chemotherapy-induced peripheral neuropathy. https://authors.elsevier.com/c/1ko~33AAzzosDZ23 Mar 2025 04:07 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lkzek7p7622shttps://bsky.app/profile/aliasgersalem.bsky.social/post/3ljsmyjscq22xThe John Pappajohn Entrepreneurial Center at U Iowa plays a critical role in promoting entrepreneurship and supporting start up companies. This includes running the NSF I-Corps program that I currently help to lead. Read more about my own JPEC experience here: https://iowajpec.org/news/2025/03/entrepreneurial-mindset-drives-salems-startups-innovation-and-impact07 Mar 2025 18:24 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3ljsmyjscq22xhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3ljsm5asmds2qThe University Lecture Committee organized an event: “An evening with Dr. Siddhartha Mukherjee: The Art of Cancer Research” on March 4th. He read from his book “The Emperor of All Maladies: A Biography of Cancer” and shared his thoughts on the current state of cancer research.07 Mar 2025 18:09 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3ljsm5asmds2qhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lizcz72qls2qSelenium is an essential nutrient named after the Greek goddess of the Moon − crucial to health, it may help prevent and treat cancer. Click on the link below to learn more: https://theconversation.com/selenium-is-an-essential-nutrient-named-after-the-greek-goddess-of-the-moon-crucial-to-health-it-may-help-prevent-and-treat-cancer-24854825 Feb 2025 16:49 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lizcz72qls2qhttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lis2asqzj22cIn press: Gene‑activation of surface‑modified 3D printed calcium phosphate scaffolds. Noah Zach Laird, Pornpoj Phruttiwanichakun, Esraa Mohamed, Timothy Acri, LR Jaidev Chakka, Aliasger K. Salem. BMC Chemistry. 2025. rdcu.be/eaP2H @UIPharmacy https://rdcu.be/eaP2H22 Feb 2025 19:24 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lis2asqzj22chttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lipe5xrdkc2iI am pleased to share that myself, Mark Greiner (University of Iowa) and Sara Thomasy (UC Davis) have been awarded a new National Institutes of Health (National Eye Institute) R01 grant for $2.85 million focused on "Modulating Ferroptosis in Fuchs Endothelial Corneal Dystrophy".21 Feb 2025 17:43 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lipe5xrdkc2ihttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lhyj6y3nk22oRead my latest article discussing indirect costs on @NIH grants: "How much does scientific progress cost? Without government dollars for research infrastructure, breakthroughs become improbable." in The Conversation. https://theconversation.com/how-much-does-scientific-progress-cost-without-government-dollars-for-research-infrastructure-breakthroughs-become-improbable-24956612 Feb 2025 15:42 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lhyj6y3nk22ohttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lhrlt3ihbc23Indirect costs are how the government supports research infrastructure for the nation and are critical to all research activities. They cover real expenses, including buildings and labs, equipment, and staff who support our research. The figure below shows what indirects cover09 Feb 2025 21:40 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lhrlt3ihbc23https://bsky.app/profile/aliasgersalem.bsky.social/post/3lh563zaglk27Collaborative study led by Dr. Yousef Zakharia in press: Phase I Clinical Trial of High Doses of Seleno-L-methionine in Combination with Axitinib in Patients with Previously Treated Metastatic Clear Cell Renal Cell Carcinoma. https://doi.org/10.1158/1078-0432.CCR-24-323401 Feb 2025 18:42 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lh563zaglk27https://bsky.app/profile/aliasgersalem.bsky.social/post/3lh55ibrjik27In press: 3D bioprinted ferret mesenchymal stem cell-laden cartilage grafts for laryngotracheal reconstruction in a ferret surgical model. McMillan et al. Biomaterials Science. https://pubs.rsc.org/en/content/articlelanding/2025/bm/d4bm01251h01 Feb 2025 18:31 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lh55ibrjik27https://bsky.app/profile/aliasgersalem.bsky.social/post/3lgsp5pd2j22iRead the following article: Medical research depends on government money – even a day’s delay in the intricate funding process throws science off-kilter. This article describes the rigorous process by which NIH make research project grant funding decisions. https://theconversation.com/medical-research-depends-on-government-money-even-a-days-delay-in-the-intricate-funding-process-throws-science-off-kilter-24829028 Jan 2025 14:47 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lgsp5pd2j22ihttps://bsky.app/profile/aliasgersalem.bsky.social/post/3lgom3wvnyk25In proud to share that Esraa Mohamed has been featured in this year's University of Iowa Dare to Discover Campaign. Esraa is developing therapies to counteract toxic gas exposures. Learn more at the following page: dare.research.uiowa.edu/mohamed-esraa/ https://dare.research.uiowa.edu/mohamed-esraa/26 Jan 2025 23:42 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lgom3wvnyk25https://bsky.app/profile/aliasgersalem.bsky.social/post/3lggdfzgjwc2mMeet phosphine, a gas commonly used for industrial fumigation that can damage your lungs, heart and liver. https://theconversation.com/meet-phosphine-a-gas-commonly-used-for-industrial-fumigation-that-can-damage-your-lungs-heart-and-liver-24582123 Jan 2025 16:45 +0000at://did:plc:asf6dhpplodpmwrfowzz7eb2/app.bsky.feed.post/3lggdfzgjwc2m