PhD. Genetic epidemiologist Researching mechanisms of chronic long-term conditions, ageing, and drugs @ University of Exeter, UK ❤Rstats. UCU rep✊. Views my own He/him. 🏳️‍🌈ally. 🇬🇧🇪🇺 📷 ShowYourStripes.info W: https://github.com/lcpillinghttps://bsky.app/profile/lcpilling.bsky.socialhttps://bsky.app/profile/lcpilling.bsky.social/post/3mob4oi6dos2mFantastic talk by @denizturkmen.bsky.social at #ESHG2026 on her study of oral corticosteroids: cumulative dose, adverse outcomes, and genetic modifiers of risk14 Jun 2026 15:49 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mob4oi6dos2mhttps://bsky.app/profile/lcpilling.bsky.social/post/3mo5usuvzkk24Lots of great @exeter.ac.uk researchers here #eshg20266 with talks and posters: check them out!13 Jun 2026 08:51 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mo5usuvzkk24https://bsky.app/profile/lcpilling.bsky.social/post/3mo5ul2mwk224Excited to be at #eshg2026 - I'm in session C02, interesting talks on longitudinal disease modelling and genetics If you're here pop me a message and let's get a coffee!13 Jun 2026 08:46 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mo5ul2mwk224https://bsky.app/profile/lcpilling.bsky.social/post/3mlq6vd3c2c2ySo anyone got any good holiday plans whilst access to both UK Biobank and Our Future Health are suspended? https://media.tenor.com/veQdxAVSkGUAAAAC/yaz-tatili-plaj.gif?hh=250&ww=46213 May 2026 11:23 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mlq6vd3c2c2yhttps://bsky.app/profile/lcpilling.bsky.social/post/3ml2kpgz66c2wIs there anything more satisfying than overcoming an analytic/coding challenge before it has got too late? #sohappy #goodnight https://media.tenor.com/bt3fZPmmK0QAAAAC/niccage-trancendental.gif?hh=294&ww=49804 May 2026 20:56 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3ml2kpgz66c2whttps://bsky.app/profile/lcpilling.bsky.social/post/3mkp75qufxc2jGWAS meta-analysed summary statistics for 72 long-term conditions from the GEMINI collaborative updated to v1.1 🌟 The input GWAS are the same but we have fixed several minor issues since the original release v1.0 See our GitHub for links (incl. to Zenodo) https://github.com/GEMINI-multimorbidity30 Apr 2026 08:30 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mkp75qufxc2jhttps://bsky.app/profile/lcpilling.bsky.social/post/3mjyod522nk2kThis is truly fascinating, excellent paper. Likely true for a great many diagnoses, which we totally miss by including all cases in GWAS and adjust for age [contains quote post or other embedded content]21 Apr 2026 09:30 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mjyod522nk2khttps://bsky.app/profile/lcpilling.bsky.social/post/3mgsxaahiz22nStill manually merging UK Biobank-linked health data? Faffing with Swiss Army Knife to extract variants or create polygenic scores? 🧬 I built {ukbrapR} so we could spend more time on science and less on data plumbing If it helps you, please cite! 📊 citation('ukbrapR') https://github.com/lcpilling/ukbrapR11 Mar 2026 22:38 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mgsxaahiz22nhttps://bsky.app/profile/lcpilling.bsky.social/post/3mfmjfbak5c2sNiche R package with epidemiology tools anyone? 📦 Named it {yodr} (phonetically "Yoda") which I cannot believe no-one has done before to be honest! Main functions are for "tidy" model output (extends {broom} package) and PheWAS. Also functions for extreme p-values, etc lcpilling.github.io/yodr24 Feb 2026 15:49 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mfmjfbak5c2shttps://bsky.app/profile/lcpilling.bsky.social/post/3me7alay5xk2qThe scale of this whole genome analysis conditioning across large biobanks is extraordinary, revealing novel LDL cholesterol biology 🧪 Bravo to @hiwwright.bsky.social, @drghawkes.bsky.social and the teams from Exeter and Geneva 👏 See Harry's post below for a wonderful analysis & results breakdown [contains quote post or other embedded content]06 Feb 2026 15:42 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3me7alay5xk2qhttps://bsky.app/profile/lcpilling.bsky.social/post/3me24rbe4dc2mLatest output from the GEMINI (genetics of multiple long-term conditions) team 🧬 We used genetics to subtract the effect of obesity, revealing multiple conditions that 1) share obesity as a common cause or 2) share other causes 🌟 strong implications for intervention 🥼 Paper https://doi.org/10.1038/s43856-025-01347-y04 Feb 2026 14:50 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3me24rbe4dc2mhttps://bsky.app/profile/lcpilling.bsky.social/post/3mdlu2q5t722mHear about the awesome research into Healthy Ageing and Chronic Disease @exeter.ac.uk Fantastic overview from the always inspiring @janemasoli.bsky.social Special mention to @lornah.bsky.social, Chris Scotton, and the 100s of fabulous colleagues behind the science https://www.youtube.com/watch?v=kGlYtmAMpIU29 Jan 2026 22:37 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mdlu2q5t722mhttps://bsky.app/profile/lcpilling.bsky.social/post/3mdidq7xfx22aUpdate to my UK Biobank R package {ukbrapR} 🌟 Get imputed variants (load genos or for PGS) using chr:pos not RSIDs (+ MAF, INFO etc). It can also do this for DRAGEN WGS 🐉 Thanks to @harrygreentkd.bsky.social for the help (and pub+pint whilst bug checking!) 🍻 v0.3.10 :: https://github.com/lcpilling/ukbrapR28 Jan 2026 13:07 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mdidq7xfx22ahttps://bsky.app/profile/lcpilling.bsky.social/post/3md3zef77vs2uGot to say, pretty impressed by the GitHub Copilot coding agent... for repos with my existing code it is fantastic for extending to new analyses that I am interested in doing i.e., it looks at your coding style, data structures, etc and creates a Pull Request for you to review23 Jan 2026 15:30 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3md3zef77vs2uhttps://bsky.app/profile/lcpilling.bsky.social/post/3mcrrfnnpys2cI don't normally do work on Saturdays (though often end up catching up in evenings due to young children etc) These Saturday GitHub commits were on nerdy personal repos where I annually analyse data about my central heating (Raspberry Pi managed) and my car fuel efficiency 😅 a wild Saturday evening19 Jan 2026 13:40 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mcrrfnnpys2chttps://bsky.app/profile/lcpilling.bsky.social/post/3mbr4gqbn7c27Bookmarked! 🔖 [contains quote post or other embedded content]06 Jan 2026 14:00 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mbr4gqbn7c27https://bsky.app/profile/lcpilling.bsky.social/post/3mabcow76vc2lSomehow finished my to-do list (well, the urgent stuff) so early Xmas present to myself is a few (uninterrupted? 🤞) days on DNAnexus with the new release of UK Our Future Health data 🤩 https://media.tenor.com/DqtphPIl-mYAAAAC/opening-presents-eric-cartman.gif?hh=498&ww=49818 Dec 2025 13:44 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3mabcow76vc2lhttps://bsky.app/profile/lcpilling.bsky.social/post/3m7hw7t2onk2gGreat to be back at the @ukbiobank.bsky.social scientific conference 2025 to meet old friends and make new collaborations #UKBSC25 Positive opening remarks from Prof Collins RE growing data linkages (GP data actually incoming? 🤞) and amazing research outputs Message if you're here and want to chat08 Dec 2025 11:24 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3m7hw7t2onk2ghttps://bsky.app/profile/lcpilling.bsky.social/post/3m7amnaaa422d(Re)discovered the ability to "mute" words from the feed. I come here for your niche science, health data, and genetics posts ❤️ I do not need anything about cats or certain megalomanic billionaires (though at least your cat pictures were cute)05 Dec 2025 13:44 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3m7amnaaa422dhttps://bsky.app/profile/lcpilling.bsky.social/post/3m6mrsstd5k2zReally enjoyed a joint meeting earlier between Exeter rare genetics team and @celsoneto.bsky.social and colleagues from the Human Genomics without Racism (HUGERA) project 🧬 Really complex area. Looking forward to considering how to better consider genetic diversity and self-identified ethnicity!27 Nov 2025 16:24 +0000at://did:plc:aumxuh5jdrj4kd6wsb5ffsoq/app.bsky.feed.post/3m6mrsstd5k2z