Scientist & Professor. MarignaniLab.com Precision Oncology/Model Systems/Signal Transduction/Single Cell Transcriptomics/AI/sometimes athlete. Creative Destruction Lab (CDL) Scientist/Business Strategist ORCID: 0000-0001-8070-905Xhttps://bsky.app/profile/pmarignani.bsky.socialhttps://bsky.app/profile/pmarignani.bsky.social/post/3mqjhjngoyk2kFantastic interview with Dr. Rafaela Andrade, a former PhD student from my lab who went on to build a multimillion dollar biotech company focused on muscle health. Mentorship matters. https://thisisepigenetics.podbean.com/e/interview-with-dr-rafaela-andrade/13 Jul 2026 10:15 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mqjhjngoyk2khttps://bsky.app/profile/pmarignani.bsky.social/post/3mplhowz6ik2tHappy Birthday Canada.01 Jul 2026 11:58 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mplhowz6ik2thttps://bsky.app/profile/pmarignani.bsky.social/post/3mpewk37vfs26❤️🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦⚽28 Jun 2026 21:35 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mpewk37vfs26https://bsky.app/profile/pmarignani.bsky.social/post/3mp4odolnyc23This level of energy input is not for the weak.25 Jun 2026 14:47 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mp4odolnyc23https://bsky.app/profile/pmarignani.bsky.social/post/3movcbjkypc2vPreprint from marignanilab.com. LKB1 isn't just a tumour suppressor kinase with metabolic function; there's more😁. We used scRNAseq, CRISPR, patient tumours, METABRIC genomics & new mouse model to ask:what is the impact of losing LKB1 expression on breast cancer? https://www.biorxiv.org/content/10.64898/2026.06.17.732963v1.full22 Jun 2026 16:23 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3movcbjkypc2vhttps://bsky.app/profile/pmarignani.bsky.social/post/3mounegpmv224🌞☕🏃🏻‍♀️22 Jun 2026 10:09 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mounegpmv224https://bsky.app/profile/pmarignani.bsky.social/post/3moqw62bch22n.....perfect balance of protein, lipids and carbs! #bibimbap20 Jun 2026 22:35 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3moqw62bch22nhttps://bsky.app/profile/pmarignani.bsky.social/post/3monclmgj2c2e🌤️☕👩🏻‍💻 Spatial distribution of the proteome in the human body and in cancers. The authors present a comprehensive human proteomic landscape, by profiling>13,000 proteins across 2,856 samples. Dataset spans 58 major tissue types, 251 specific tissue subtypes and 25 distinct carcinomas. t.co/GxtrlhTjMb https://t.co/GxtrlhTjMb19 Jun 2026 12:07 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3monclmgj2c2ehttps://bsky.app/profile/pmarignani.bsky.social/post/3mm2fqlvc6k27....slowly easing back into climbing....very slow. Just getting here took some time. Goal: climb midway with controlled descent. Aim1. Put climbing shoes on Aim2. Chalk up hands Aim3. Just do it.17 May 2026 12:53 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mm2fqlvc6k27https://bsky.app/profile/pmarignani.bsky.social/post/3mlb2jv3nfs2kThere is still time to register for Hot Topics in Basic and Translational Science @iaslc.bsky.social in Dublin, Ireland, June 26-27, 2026! ht26-iaslc.eventsair.site https://ht26-iaslc.eventsair.site/07 May 2026 10:55 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mlb2jv3nfs2khttps://bsky.app/profile/pmarignani.bsky.social/post/3mkztewhzt22dI am deeply honoured to receive the Alumni of Distinction Award for Excellence in Basic Science Research, Schulich School of Medicine and Dentistry 2026- Western University https://www.schulich.uwo.ca/about/news-events-community/news/2026/six-alumni-honoured-with-2026-alumni-of-distinction-awards.html04 May 2026 13:59 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mkztewhzt22dhttps://bsky.app/profile/pmarignani.bsky.social/post/3mkh76cr33s25🌞☕👩🏻‍💻 Organ aging signatures in the plasma proteome track health and disease. 😳🤔 https://www.nature.com/articles/s41586-023-06802-127 Apr 2026 04:09 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mkh76cr33s25https://bsky.app/profile/pmarignani.bsky.social/post/3mkdlayxk6c27Today, April 25th, my family commemorates Festa della Liberazione. 🇮🇹 1945, the Italian Resistance, and Allied forces, liberated Italia from fascist dictatorship and Nazi occupation. We honor the courage of the Marchigiani partigiani who fought for the liberty Italy enjoys tod #25Aprile #Italy25 Apr 2026 17:35 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mkdlayxk6c27https://bsky.app/profile/pmarignani.bsky.social/post/3mjh2yfuw3c2r🌨️☕👩🏻‍💻 https://link.springer.com/article/10.1038/s44319-026-00727-214 Apr 2026 09:29 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mjh2yfuw3c2rhttps://bsky.app/profile/pmarignani.bsky.social/post/3mj6pqlvmkc2rWelcome back Earthlings👽😁🧑🏻‍🚀👨🏾‍🚀👨🏻‍🚀👨🏻‍🚀🚀🛸🌑 [contains quote post or other embedded content]11 Apr 2026 01:47 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mj6pqlvmkc2rhttps://bsky.app/profile/pmarignani.bsky.social/post/3mivlmifjxk2c,🌞☕👩🏻‍💻 Chromosome 15q15 Deletion Drives Brain Metastasis in NSCLC - Journal of Thoracic Oncology https://www.jto.org/article/S1556-0864%2825%2902894-1/fulltext07 Apr 2026 10:39 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mivlmifjxk2chttps://bsky.app/profile/pmarignani.bsky.social/post/3mitbzoukdk2z🌞☕👩🏻‍💻 Landscape and functional impact of variants of unknown significance of immune response genes in human cancer. https://www.linkedin.com/safety/go/?url=https%3A%2F%2Fwww%2Enature%2Ecom%2Farticles%2Fs41417-026-01024-9&urlhash=wZwu&mt=XyHz-sDhFeCyJ51zKDZQOg5oMupiNxBEywaR6Sf4iUqq8Q0bsEbdV7koGiqEm5MIBvKwmmNXkywP2lVhjcjXKR6fWLzPygInpMz2yN9Z8dBwzdapncca&isSdui=true06 Apr 2026 12:42 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mitbzoukdk2zhttps://bsky.app/profile/pmarignani.bsky.social/post/3mihr2ysqlk2m🚀 History is happening. For the 1st time in 53yrs, humans are on their way to the Moon. NASA's #ArtemisII crew; Commander Reid Wiseman, Pilot Victor Glover, Mission Specialist Christina Koch, and 🇨🇦 astronaut Jeremy Hansen have lifted off aboard the Orion #NASA #Artemis #SpaceExploration #Moon01 Apr 2026 22:39 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mihr2ysqlk2mhttps://bsky.app/profile/pmarignani.bsky.social/post/3mi2quesmlc2hThere is always room for Bibimbap.27 Mar 2026 18:31 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mi2quesmlc2hhttps://bsky.app/profile/pmarignani.bsky.social/post/3mhar7vxjtc2h💨☕👩‍💻Excited to share our recent discovery. Tumour suppressors LKB1 and SMARCA4 working together to regulate gene expression, acting as a nexus between metabolism and chromatin remodelling. #LungCancer #CancerResearch #Epigenetics #Metabolism #LKB1 #SMARCA4 https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1685342/full17 Mar 2026 10:28 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mhar7vxjtc2hhttps://bsky.app/profile/pmarignani.bsky.social/post/3mgpmjzkljk2lWhat do Signal Transduction, Neural Networks, Artificial Intelligence and Agentics, all have in common? COMMUNICATION. Join us at @dalhousie.bsky.social for an afternoon of science, technology and Guglielmo Marconi. https://events.dal.ca/medicine/event/5651-the-evolution-of-communication-guglielmo-marconi-to-age?utm_source=myDalDaily&utm_medium=email&utm_campaign=myDalDaily10 Mar 2026 14:49 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mgpmjzkljk2lhttps://bsky.app/profile/pmarignani.bsky.social/post/3mgnsb4fdj22dPlease join us on March 11th to celebrate the Evolution of Communication: Marconi to Agentic AI. Faculty of Medicine,Tupper Medical Bldg,Theatre A,4pm. Welcome Italian Ambassador to Canada H.E Alessandro Cattaneo to @dalhousieu.bsky.social @dalhousie.bsky.social 🇨🇦🇮🇹 Open to our Halifax community.09 Mar 2026 21:26 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mgnsb4fdj22dhttps://bsky.app/profile/pmarignani.bsky.social/post/3mgka635t3k2zHappy International Women's Day! Today, I am celebrating the incredible strength, resilience, and achievements of women that lift me. In a world facing instability, it's women and girls who are often most affected, facing increased risks and deeper inequalities. #InternationalWomensDay #IWD202608 Mar 2026 11:24 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mgka635t3k2zhttps://bsky.app/profile/pmarignani.bsky.social/post/3mgf5sv6bgs2p🌞☕👩🏻‍💻 Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy https://www.science.org/doi/10.1126/science.ads397206 Mar 2026 10:59 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mgf5sv6bgs2phttps://bsky.app/profile/pmarignani.bsky.social/post/3mgbuwwbrxc2rAt the end of the day.....of CIHR grant submission. 🎻05 Mar 2026 03:42 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mgbuwwbrxc2rhttps://bsky.app/profile/pmarignani.bsky.social/post/3mg7y2otgkc26 ❄️☕👩🏻‍💻 🧐SCC demonstrates sensitivity with immunochemotherapy, but non-SCC, especially with KRAS+KEAP1/STK11 co-mutations, represents a distinct, immune-cold, high-risk subtype. https://www.jto.org/article/S1556-0864(25)02860-6/fulltext?dgcid=raven_jbs_etoc_email04 Mar 2026 09:32 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mg7y2otgkc26https://bsky.app/profile/pmarignani.bsky.social/post/3mg66zhhvtc2kI have been asked by many of you to share my LinkedIn post regarding internal deadlines. Here you go. https://www.linkedin.com/posts/drpaolamarignani_science-funding-in-canada-statistics-activity-7424995642248163328-e19G?utm_source=share&utm_medium=member_android&rcm=ACoAAATMRgIBBKDkWOqOOEEU0DUY5Onh1peCchc03 Mar 2026 16:32 +0000at://did:plc:az6fsd26srbpr7bht7iw65kd/app.bsky.feed.post/3mg66zhhvtc2k