The Alon lab explores design principles of biological circuits, focusing on systems medicine, aging, and healthspan.https://bsky.app/profile/urialonlab.bsky.socialhttps://bsky.app/profile/urialonlab.bsky.social/post/3mv2x7jbnws24Excited to be speaking at the 2026 Biomarkers of Aging Conference, October 5-6, at Harvard Medical School's Joseph B Martin Conference Center. https://www.agingconsortium.org/2026-conference09 Sep 2026 06:52 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3mv2x7jbnws24https://bsky.app/profile/urialonlab.bsky.social/post/3mtjeybi5hc2vHappy to share that I was named one of TIME’s 2026 Longevity Leaders. Our work uses physics-style theory to look for simple principles that can explain the complex dynamics of aging. https://x.com/UriAlonWeizmann/status/2090434928454353304?s=2020 Aug 2026 13:45 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3mtjeybi5hc2vhttps://bsky.app/profile/urialonlab.bsky.social/post/3mpnirtmg622mWhy do animals age in such similar ways, yet live for wildly different spans - from days to a century? Our new paper in @NatureAging fits a damage accumulation model across 9 species and finds the knob that best predicts lifespan https://doi.org/10.1038/s43587-026-01138-702 Jul 2026 07:23 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3mpnirtmg622mhttps://bsky.app/profile/urialonlab.bsky.social/post/3mnouwfug7s2aWhat happens just before we die? Are the last stages of deterioration driven by different dynamics, or the same processes driving aging all our lives? Turns out it's the latter, as we show in our new preprint! 🔬 https://doi.org/10.64898/2026.04.20.719588 🧵 1/5 #AgingResearch #SystemsBiology07 Jun 2026 09:43 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3mnouwfug7s2ahttps://bsky.app/profile/urialonlab.bsky.social/post/3ml6oeh7tzk2gIdentify. Attack. Resolve. The immune system follows a perfect defense program: ignore weak/self signals, attack true threats with force, then shut down to avoid damage. (1/2) https://www.science.org/doi/10.1126/sciadv.aeb092106 May 2026 12:12 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3ml6oeh7tzk2ghttps://bsky.app/profile/urialonlab.bsky.social/post/3m75jjctank2mRecommended listening. I was hosted on the podcast “Gil Hameever” to discuss our latest paper about the sudden physiological changes at menopause. The conversation is in Hebrew. https://open.spotify.com/episode/0EVAx0NRJwwGtqGEzN9sZ904 Dec 2025 08:11 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3m75jjctank2mhttps://bsky.app/profile/urialonlab.bsky.social/post/3m72yxtkuy222We analyzed changes in physiology relative to menopause using two large scale studies that include millions of lab tests. Rather than align by age, we used statistical inference to align tests to final menstrual period. (1/2) https://arunamed.com/the-menopause-cliff-what-a-million-womens-lab-tests-reveal/03 Dec 2025 08:09 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3m72yxtkuy222https://bsky.app/profile/urialonlab.bsky.social/post/3lpz7bhbryc2dWhy does innovative research necessitate a jump into the unknown? Find out (and much more) in episode 147 of רעב לידע עם אור דניאל (Hungry for Knowledge with Or Daniel)! https://www.learntech.co.il/podcast/pod147/25 May 2025 17:39 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lpz7bhbryc2dhttps://bsky.app/profile/urialonlab.bsky.social/post/3lni5sy626k2vSweet moment in life, our 25th lab anniversary. In a circle, we looked at each other, a group of people with shared values and a soft approach, who want each other to succeed and be happy. (1/2)23 Apr 2025 12:07 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lni5sy626k2vhttps://bsky.app/profile/urialonlab.bsky.social/post/3lmw54mrbhc2wMasterpiece by a masterful scientist Natural Neuroscience by Nachum Ulanovsky @mitpress.bsky.social https://mitpress.mit.edu/9780262044998/natural-neuroscience/16 Apr 2025 08:07 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lmw54mrbhc2whttps://bsky.app/profile/urialonlab.bsky.social/post/3lmjzqvp5xk2nOur latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans. By @y1fanyang.bsky.social , out now @naturecomms.bsky.social https://www.nature.com/articles/s41467-025-57807-511 Apr 2025 12:34 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lmjzqvp5xk2nhttps://bsky.app/profile/urialonlab.bsky.social/post/3llojvhldw22uNow in French and Spanish - our pregnancy paper is highlighted also in @lefigaro.fr and @elpais.com https://sante.lefigaro.fr/medecine/comment-la-grossesse-chamboule-la-physiologie-de-la-future-mere-et-pourquoi-elle-ne-redevient-jamais-vraiment-elle-meme-20250326 https://elpais.com/salud-y-bienestar/2025-03-26/asi-altera-el-embarazo-el-organismo-de-la-mujer-la-cuarentena-no-es-suficiente-para-devolver-los-parametros-fisiologicos-a-la-normalidad.html31 Mar 2025 14:09 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3llojvhldw22uhttps://bsky.app/profile/urialonlab.bsky.social/post/3llmbh5z5hc2p"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet" Our study highlighted in @nature.com News https://www.nature.com/articles/d41586-025-00959-730 Mar 2025 16:32 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3llmbh5z5hc2phttps://bsky.app/profile/urialonlab.bsky.social/post/3lledcl7hl22rExcited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.27 Mar 2025 12:44 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lledcl7hl22rhttps://bsky.app/profile/urialonlab.bsky.social/post/3ll4zmxteuc2qTheory predicted two kinds of fibrosis, hot and cold. We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social [contains quote post or other embedded content]24 Mar 2025 15:02 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3ll4zmxteuc2qhttps://bsky.app/profile/urialonlab.bsky.social/post/3lkndbjoe6k24Sagol lecture in longevity research - Myriam Grunewald on vasculature maintenance for longevity18 Mar 2025 09:12 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lkndbjoe6k24https://bsky.app/profile/urialonlab.bsky.social/post/3liw2dh7pes2oJoin us at the ICSB in Dublin this October - I will chair the session on aging systems biology icsb2025.com24 Feb 2025 09:36 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3liw2dh7pes2ohttps://bsky.app/profile/urialonlab.bsky.social/post/3lhtiy7m7nk2fMy brilliant PhD student @Yaelebel.bsky.social gave a talk at the Azrieli Graduate Students forum about her research on using excitable dynamics to explain pulsatile immune phenomena, and how research questions can come from the most unexpected places. Well done Yael! youtu.be/MdwqWx5emo4 https://youtu.be/MdwqWx5emo410 Feb 2025 15:55 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lhtiy7m7nk2fhttps://bsky.app/profile/urialonlab.bsky.social/post/3lhrfmipvzc23Will be attending the Quantitative Immunology workshop at the Princeton Center for Theoretical Science later month. https://pcts.princeton.edu/events/2025/quantitative-immunology09 Feb 2025 19:49 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lhrfmipvzc23https://bsky.app/profile/urialonlab.bsky.social/post/3lheg43zhzs27Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress? We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)04 Feb 2025 15:53 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lheg43zhzs27https://bsky.app/profile/urialonlab.bsky.social/post/3lgx4oh2vts2cVideos and lecture notes from my latest course, Systems Aging, are available now at: https://www.weizmann.ac.il/mcb/alon/courses/systems-aging-autumn-202430 Jan 2025 09:00 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lgx4oh2vts2chttps://bsky.app/profile/urialonlab.bsky.social/post/3lgs32jjkqm2aExcited to speak at the Global Conference on Gerophysics, where we'll explore how physics can revolutionize our understanding of aging and mortality. Join us and get 10% off registration with code GCGP10. See you there, and sign up here: https://medicine.nus.edu.sg/trp/healthy-longevity/events/global-conference-on-gerophysics/28 Jan 2025 08:48 +0000at://did:plc:b4raxmapfl4cxlwgnjomk4hi/app.bsky.feed.post/3lgs32jjkqm2a