Drug Discovery. Neuroscience. Technology. President, AI @ Pangea Biohttps://bsky.app/profile/sonaxyz.bsky.socialhttps://bsky.app/profile/sonaxyz.bsky.social/post/3lflforqef22cCould overlooking sex differences be part of the reason for stalling in Alzheimer’s research progress? Fascinating that it disproportionately affect women who represent 2/3 of patients, and estrogen seems to play a major role. #Alzheimers #Neuro #womenshealth 🧠🧐 tinyurl.com/39xtveas https://tinyurl.com/39xtveas12 Jan 2025 23:44 +0000at://did:plc:bttn4ikacurs6vxsecft6kw4/app.bsky.feed.post/3lflforqef22chttps://bsky.app/profile/sonaxyz.bsky.social/post/3ldncuxeols2uThis is pretty damn cool, new research from stanford reports building an #agingclock of the #brain using #spatialtranscriptomics. Has interesting insights on how things like exercise and disease impact brain cell aging. https://www.nature.com/articles/s41586-024-08334-819 Dec 2024 07:09 +0000at://did:plc:bttn4ikacurs6vxsecft6kw4/app.bsky.feed.post/3ldncuxeols2uhttps://bsky.app/profile/sonaxyz.bsky.social/post/3lcvbmpupyk2vInteresting.. patients on GLP-1 agonists commonly report anhedonia as a side effect of these drugs [contains quote post or other embedded content]09 Dec 2024 17:43 +0000at://did:plc:bttn4ikacurs6vxsecft6kw4/app.bsky.feed.post/3lcvbmpupyk2vhttps://bsky.app/profile/sonaxyz.bsky.social/post/3lcv6tjbcsk26Insight into the #neurobiology of #addiction: Drugs like morphine boost myelination in dopaminergic neurons & the reward circuit, increasing signaling + reinforcing addictive behaviors. Conversely,blocking myelination reduced drug-seeking. Could be interesting for #therapeutics? tinyurl.com/ywznzdzn https://tinyurl.com/ywznzdzn09 Dec 2024 16:53 +0000at://did:plc:bttn4ikacurs6vxsecft6kw4/app.bsky.feed.post/3lcv6tjbcsk26https://bsky.app/profile/sonaxyz.bsky.social/post/3lcdmrv34m22oIf Vertex's suzetrigine is approved, it will be the first non-opioid (NaV1.8 inhibitor) for severe pain. Payors face a dilemma: stick w/ protocol of covering cheap but addictive generic opioids, or cover a safer, pricier branded option? #pain #therapeutic #neuro #pharma #biotech tinyurl.com/4byn7s92 https://tinyurl.com/4byn7s9202 Dec 2024 17:14 +0000at://did:plc:bttn4ikacurs6vxsecft6kw4/app.bsky.feed.post/3lcdmrv34m22ohttps://bsky.app/profile/sonaxyz.bsky.social/post/3lcbola4ajc2qCan the therapeutic benefit of psychedelics be unlocked w/o the trip? Only time (& clinical studies) will tell. In mice, scientists managed to identify & reactivate the neural circuits for anxiety relief while bypassing those causing hallucinations. tinyurl.com/3c6v4w3v #neuroscience #therapeutics https://tinyurl.com/3c6v4w3v01 Dec 2024 22:41 +0000at://did:plc:bttn4ikacurs6vxsecft6kw4/app.bsky.feed.post/3lcbola4ajc2q