Mostly #cryoEM-related tweets. Group leader at a biotech company in the Bay Area. Views are my own. https://github.com/warpem/warphttps://bsky.app/profile/dtegunov.bsky.socialhttps://bsky.app/profile/dtegunov.bsky.social/post/3mo6nzo3kpk27So many people waking up today wishing they had prompted Fable a bit longer last night 😱 The government's reaction is completely overblown, of course. But it is a bit better than Opus 4.8 on average – enough that I wouldn't go back voluntarily if cost wasn't a factor13 Jun 2026 16:22 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mo6nzo3kpk27https://bsky.app/profile/dtegunov.bsky.social/post/3mm7tvifqd22wGenuinely is the new delve19 May 2026 16:49 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mm7tvifqd22whttps://bsky.app/profile/dtegunov.bsky.social/post/3mkwiqbcwss2rWe're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: https://www.biorxiv.org/content/10.64898/2026.04.29.721716v1 Code: https://github.com/warpem/miss-alignment/ 🧶 Thread:03 May 2026 06:10 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mkwiqbcwss2rhttps://bsky.app/profile/dtegunov.bsky.social/post/3mkq4ahbqc22pNow my mailing list reply bot is getting spam targeted specifically at agents: containing an API key for the advertised service, and instructions to try it out and to copy part of the message as a skill .md to Claude's config. I wonder how often Claws running without any human oversight bite on that30 Apr 2026 17:11 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mkq4ahbqc22phttps://bsky.app/profile/dtegunov.bsky.social/post/3mizt32q65c2bLooks like electron cryo-microscopy/tomography has finally lost the battle [contains quote post or other embedded content]09 Apr 2026 03:03 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mizt32q65c2bhttps://bsky.app/profile/dtegunov.bsky.social/post/3meyquxuahc2kSomewhat related: I was looking for a JS library to read MRC files a while ago, but couldn't find one (sorry if I missed it). So you can now “npm install @warpem/mrc-parser” https://github.com/warpem/mrc-parser [contains quote post or other embedded content]16 Feb 2026 19:10 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3meyquxuahc2khttps://bsky.app/profile/dtegunov.bsky.social/post/3mex3fhgyyc25I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/ https://warpem.github.io/euler-hunt/16 Feb 2026 03:13 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mex3fhgyyc25https://bsky.app/profile/dtegunov.bsky.social/post/3merdmu57mc2sOnce you install peonping.com, don't forget to mute the volume if you decide to claude something during a meeting https://peonping.com13 Feb 2026 20:24 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3merdmu57mc2shttps://bsky.app/profile/dtegunov.bsky.social/post/3mepenri3hs2bA cats lock key that lets you quickly disable the keyboard when a cat approaches it would be a lot more useful than the antiquated caps lock13 Feb 2026 01:37 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mepenri3hs2bhttps://bsky.app/profile/dtegunov.bsky.social/post/3mempb7ezg22zWhat is the current resolution record for in situ nucleosomes? The best unofficial result I remember seeing was around 7 Å, but I feel like I've heard a better figure mentioned somewhere already12 Feb 2026 00:09 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mempb7ezg22zhttps://bsky.app/profile/dtegunov.bsky.social/post/3me7cyiyyhc2iCalifornia is famous for its sunsets, but sunny early mornings are the real magic here06 Feb 2026 16:25 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3me7cyiyyhc2ihttps://bsky.app/profile/dtegunov.bsky.social/post/3mdrggtrlgs2lDo we have “I am a robot” CAPTCHAs for Moltbook yet?01 Feb 2026 03:49 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mdrggtrlgs2lhttps://bsky.app/profile/dtegunov.bsky.social/post/3mde6h7t5p224Super happy to finally see native vertical tabs in Chrome, but why why why is the + button all the way at the bottom? #uxsky26 Jan 2026 21:22 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mde6h7t5p224https://bsky.app/profile/dtegunov.bsky.social/post/3md4c4gs7rs2gIf someone's age is a prime number, are they in their prime?23 Jan 2026 18:06 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3md4c4gs7rs2ghttps://bsky.app/profile/dtegunov.bsky.social/post/3mczpxu3rok2eThis exciting new method has a bright future!22 Jan 2026 17:36 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mczpxu3rok2ehttps://bsky.app/profile/dtegunov.bsky.social/post/3mcfzkvlvhk2jGreat CV advice in this thread! I'll also add that for computational scientists, a GitHub/GitLab link is a must. Sure, there are people whose work I know well enough to not care about their repos, but don't bet on that. [contains quote post or other embedded content]14 Jan 2026 21:35 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mcfzkvlvhk2jhttps://bsky.app/profile/dtegunov.bsky.social/post/3mbd37bmem22d2026 will bring great tilt series alignments for the ribosome-deficient among us 🎆01 Jan 2026 00:01 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3mbd37bmem22dhttps://bsky.app/profile/dtegunov.bsky.social/post/3m7yjkebhrs2aHere is why friends don't let friends calculate FSC on denoised half-maps. I took EMD-17961, denoised the maps using Warp's Noise2Map, and calculated the FSC between various things. With noise gone from the half-maps, their consistency is no longer related to SSNR. Denoised map vs. model still works [contains quote post or other embedded content]15 Dec 2025 01:53 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3m7yjkebhrs2ahttps://bsky.app/profile/dtegunov.bsky.social/post/3m7vfsar5y22zDon't get me wrong: the original IsoNet was the coolest thing to happen in cryoET in at least a decade. But after the initial “wow” moment it's time to make this topic more sciency [contains quote post or other embedded content]13 Dec 2025 20:08 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3m7vfsar5y22zhttps://bsky.app/profile/dtegunov.bsky.social/post/3m5ws5k3t5k2lI'm not superstitious but I never set my TV's volume to 1318 Nov 2025 22:31 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3m5ws5k3t5k2lhttps://bsky.app/profile/dtegunov.bsky.social/post/3m4e3cd3za22tI'm used to seeing driverless Waymos at this point, but seeing a Waymo with no driver *and* no passengers roll down a hill still gave me a moment of “OMG THE PARKING BRAKE FAILED” panic29 Oct 2025 18:29 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3m4e3cd3za22thttps://bsky.app/profile/dtegunov.bsky.social/post/3m3gidmlpus2uCool, definitely a visual improvement! But do I understand correctly the FSC was calculated between 2 *denoised* half-maps? You can't quantify resolution like that, only consistency. [contains quote post or other embedded content]18 Oct 2025 00:03 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3m3gidmlpus2uhttps://bsky.app/profile/dtegunov.bsky.social/post/3m36vzc7iqs2i😂 [contains quote post or other embedded content]14 Oct 2025 23:46 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3m36vzc7iqs2ihttps://bsky.app/profile/dtegunov.bsky.social/post/3m2u555mn3s2eOMG they will go so well with my Bliss ugly Christmas sweater [contains quote post or other embedded content]10 Oct 2025 16:54 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3m2u555mn3s2ehttps://bsky.app/profile/dtegunov.bsky.social/post/3m2fdh734nk2uIt took me several weeks to notice how perfect this arrangement was04 Oct 2025 19:37 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3m2fdh734nk2uhttps://bsky.app/profile/dtegunov.bsky.social/post/3lzmzgfwjnk26The things Apple will do to procrastinate improving Siri [contains quote post or other embedded content]25 Sep 2025 03:34 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3lzmzgfwjnk26https://bsky.app/profile/dtegunov.bsky.social/post/3lzm2uvmrgc2vUgh, I'm starting to get spam texts with em dashes24 Sep 2025 18:27 +0000at://did:plc:bug57faqqvt3zrub2epbbs33/app.bsky.feed.post/3lzm2uvmrgc2v