Manhiça Tuberculosis Initiative. Working towards improving TB control through the development of new diagnostic tools, treatments & vaccines. We are a team based in between Barcelona at @isglobal.org and Manhiça @manhica_cismhttps://bsky.app/profile/mtbi.bsky.socialhttps://bsky.app/profile/mtbi.bsky.social/post/3ms5yypb2kc25🔍 TB doesn't always present with the "classic" symptoms. A new study from England found that around one person per week dies with undiagnosed TB, with diagnosis only made after death. 📰 Read the study: https://thorax.bmj.com/content/early/2026/06/16/thorax-2025-224505 #Tuberculosis #EndTB03 Aug 2026 07:46 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3ms5yypb2kc25https://bsky.app/profile/mtbi.bsky.social/post/3mrfhvkqkns25Congratulations to a member of our MTBI group, Lucía Carratalá Castro, on the defense of her PhD thesis, entitled "New Approaches to Diagnose Tuberculosis in Children"! 👏24 Jul 2026 13:36 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mrfhvkqkns25https://bsky.app/profile/mtbi.bsky.social/post/3mlndvwb4mc2p🚨 New research from Mozambique and Tanzania shows decentralised TB testing with Truenat can deliver faster results, quicker treatment, and better access to care for vulnerable communities. 🧪🏥 Read more: https://gh.bmj.com/content/11/5/e019902 #EndTB #Tuberculosis #GlobalHealth12 May 2026 08:15 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mlndvwb4mc2phttps://bsky.app/profile/mtbi.bsky.social/post/3mld7y52lpc2f🫁 New EXULTANT trial findings show that expanding Xpert MTB/RIF Ultra + LF-LAM testing in people living with HIV improves TB detection. ⚡ Faster diagnosis = faster treatment + fewer deaths in high burden settings. 🌍 Read more: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2826%2900133-7/fulltext #EndTB #TB #HIV #GlobalHealth08 May 2026 07:38 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mld7y52lpc2fhttps://bsky.app/profile/mtbi.bsky.social/post/3mkzs5azors2wAI is reshaping TB detection. WHO supports AI-powered chest X-ray tools to expand global screening. It helps close the gap in millions of missed cases. AI scales clinician expertise, not replaces it. #AI #Health #TB https://www.who.int/news/item/11-06-2025-who-approves-six-software-products-for-computer-aided-detection-of-tb-on-chest-x-ray04 May 2026 13:37 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mkzs5azors2whttps://bsky.app/profile/mtbi.bsky.social/post/3mk5vhrclas26New IJTLD Open study 🌍🫁 IGRA+ up to ~59% at baseline and >30% 12-month conversion in some sites. Clear signal of strong TB transmission heterogeneity. https://journals.theunion.org/content/ijtldo/3/4/23223 Apr 2026 11:22 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mk5vhrclas26https://bsky.app/profile/mtbi.bsky.social/post/3mjhhm57imc2d🧬 New Nature study: CMX410 shows promise as a novel TB drug targeting #Pks13, effective even against drug-resistant strains. This could help shorten long TB treatments. 🔗 https://www.nature.com/articles/s41586-025-09286-3 #Tuberculosis #GlobalHealth #DrugDiscovery14 Apr 2026 13:15 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mjhhm57imc2dhttps://bsky.app/profile/mtbi.bsky.social/post/3miyctbx5qs2r🚨 AI + digital X‑rays detect more TB in Mozambique prisons A 2026 study found AI-assisted chest X‑rays outperformed symptom screening and improved linkage to treatment and preventive care, helping close diagnostic gaps. 🔗 bit.ly/3TBmoz #Tuberculosis #Mozambique #GlobalHealth #AIinHealth #EndTB https://link.springer.com/article/10.1186/s44263-026-00256-z08 Apr 2026 12:39 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3miyctbx5qs2rhttps://bsky.app/profile/mtbi.bsky.social/post/3migsicpbgc2y🌎Colombia’s armed conflict fuels TB: more cases, more deaths. Displacement and disrupted care put communities at risk. We must keep health services running. 🔗 https://www.linkedin.com/posts/manhi%C3%A7a-tuberculosis-initiative-mtbi_un-estudio-asocia-el-conflicto-armado-en-activity-7444311201880113152-fOi701 Apr 2026 13:32 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3migsicpbgc2yhttps://bsky.app/profile/mtbi.bsky.social/post/3mg5voe7wts2xWHO has launched the 2026 World TB Day theme: “Yes! We can End TB!” The focus is stronger country leadership, increased investment, and faster rollout of new diagnostics. Ending TB is achievable with sustained action. https://www.who.int/campaigns/world-tb-day/2026 #EndTB #PublicHealth03 Mar 2026 13:44 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mg5voe7wts2xhttps://bsky.app/profile/mtbi.bsky.social/post/3mflzt3bg2s2n🦠 Anxiety is common in drug-sensitive TB but rarely addressed in routine care. A Pakistan study shows patients rely on self-coping, providers lack training, yet there’s strong support for integrated mental health care. Feasible model: sessions during TB visits. 🔗 https://link.springer.com/article/10.1186/s40359-026-04191-424 Feb 2026 11:11 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mflzt3bg2s2nhttps://bsky.app/profile/mtbi.bsky.social/post/3mej5u2orjs2kTB doesn’t stay in prisons. Prisons have TB rates 10–20× higher than the general population, with latent TB affecting ~40–50% of incarcerated people in many settings. These facilities act as reservoirs that fuel community transmission. #TB #PublicHealth #PrisonHealth #GlobalHealth10 Feb 2026 14:20 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mej5u2orjs2khttps://bsky.app/profile/mtbi.bsky.social/post/3me44j7wj322s🧪 #CRP testing for TB contacts: fingerprick = serum ✅ 1,034 contacts studied using #LumiraDx: strong agreement, 77% sensitivity at WHO cutoff, serum storage -80°C didn’t affect results ❄️ Read study: https://www.sciencedirect.com/science/article/pii/S0009898126000586?via%3Dihub #Tuberculosis #TBScreening #GlobalHealth05 Feb 2026 09:51 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3me44j7wj322shttps://bsky.app/profile/mtbi.bsky.social/post/3mdv7hdj6xk2x⚠️ Flooding in Mozambique is disrupting transport and access to care. For people with TB, treatment interruptions raise serious risks. Our team is on the ground keeping TB services running. Every dose, every patient counts. #TBcare #FloodResponse #Mozambique02 Feb 2026 15:55 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mdv7hdj6xk2xhttps://bsky.app/profile/mtbi.bsky.social/post/3mdfjvrmjwk2q📍 Last week, MTBI joined the NUS–Lancet PRIME Commission on Pandemic Justice in Singapore, bringing together global experts to reimagine equitable, community-centered pandemic preparedness. Thanks to Helena Legido-Quigley, The Rt. Honorable Helen Clark, NUS & The Lancet Group! #PublicHealth #TB27 Jan 2026 10:20 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mdfjvrmjwk2qhttps://bsky.app/profile/mtbi.bsky.social/post/3mcryfiu56s2cSeasonality of TB in Mozambique 📆 Globally, TB often peaks in spring/summer, but local patterns differ. In Maputo (2011–2016), TB notifications varied by quarter, yet models found no significant seasonal effect. Climate still shapes spatial TB risk nationwide. #TB #Mozambique19 Jan 2026 15:46 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mcryfiu56s2chttps://bsky.app/profile/mtbi.bsky.social/post/3mbvumnjpv22i💵 WHO warns that global progress against tuberculosis is at risk. TB still affects 10.7M people and causes over 1.2M deaths each year. Funding remains far below targets, threatening recent gains. Sustained investment is critical to end TB. #EndTB #GlobalHealth #WHO08 Jan 2026 11:24 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mbvumnjpv22ihttps://bsky.app/profile/mtbi.bsky.social/post/3malxgc7qhk2kHappy Holidays and Happy New Year from the @mtbi.bsky.social team! Boas festas e um feliz ano novo! 🎆22 Dec 2025 19:22 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3malxgc7qhk2khttps://bsky.app/profile/mtbi.bsky.social/post/3mabakqamms2b❄️ As winter arrives in the Northern Hemisphere, it’s a good time to revisit the seasonality of tuberculosis. Research shows TB transmission may increase during winter months due to indoor crowding and reduced sunlight, with diagnoses peaking later. pubmed.ncbi.nlm.nih.gov/21572609/ https://pubmed.ncbi.nlm.nih.gov/21572609/18 Dec 2025 13:06 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3mabakqamms2bhttps://bsky.app/profile/mtbi.bsky.social/post/3m7ze3h3fws2bNew research in Clinical Infectious Diseases: the AccuLAM study assesses the accuracy and added diagnostic value of TB-LAM for detecting TB in children without HIV, an important step toward improving pediatric TB diagnosis. https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciaf525/8317722 #Tuberculosis #GlobalHealth15 Dec 2025 09:48 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m7ze3h3fws2bhttps://bsky.app/profile/mtbi.bsky.social/post/3m5gtfb4gi227During World Science Day for Peace and Development, Dr. Dinis Nguenha from CISM shared that using the #Truenat portable molecular diagnostic system enabled 82% of TB patients to start treatment on the same day of diagnosis, improving care and reducing delays!12 Nov 2025 14:11 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m5gtfb4gi227https://bsky.app/profile/mtbi.bsky.social/post/3m5f4h5i3c227👏 Dr. Belén Saavedra Cervera (ISGlobal & CISM) wowed audiences at the XXIX Jornadas sobre Tuberculosis 2025, presenting key findings on TB transmission in Manhiça through molecular epidemiology. Thanks to #CoMB, #uiTB & #fuiTB!11 Nov 2025 21:48 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m5f4h5i3c227https://bsky.app/profile/mtbi.bsky.social/post/3m5edqr3ads27🗨️ Our PhD student, Salome Valencia, presented today at the XXIX Jornadas Internacionales sobre Tuberculosis 2025, hosted by #CoMB, #uiTB & #fuiTB. She explored how armed conflict and social inequality shape #TB in Colombia. Grateful to all for fostering these vital discussions!11 Nov 2025 14:26 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m5edqr3ads27https://bsky.app/profile/mtbi.bsky.social/post/3m5bsvypdhk27TB isn’t a disease of the past — it’s still one of the world’s top infectious killers (WHO, 2024). ❌ Not limited to certain countries ❌ A positive test ≠ contagious ✅ TB is curable, but stigma + myths slow progress. #Tuberculosis #GlobalHealth10 Nov 2025 14:19 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m5bsvypdhk27https://bsky.app/profile/mtbi.bsky.social/post/3m4ao4fudsc2gFrom new WHO guidance on TB & diabetes to innovations workshops, climate frameworks, and global commitments, 2025 is a pivotal year in the fight to #EndTB. Progress is happening, but action must continue. 🩺 #GlobalHealth28 Oct 2025 09:55 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m4ao4fudsc2ghttps://bsky.app/profile/mtbi.bsky.social/post/3m3aayxchf22iNew meta-analysis finds no clear mortality benefit from intensified treatment regimens (ie. high-dose rifampicin, fluoroquinolones) for #tuberculous #meningitis in adults. More consistent, high-quality trials needed. 📚 pubmed.ncbi.nlm.nih.gov/41064692/ https://pubmed.ncbi.nlm.nih.gov/41064692/15 Oct 2025 12:35 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m3aayxchf22ihttps://bsky.app/profile/mtbi.bsky.social/post/3m2tvjkgzdc2iNew study in PLOS ONE analyzes 255 messages between TB patients & treatment supporters using digital adherence tech (DATs). Beyond reminders, patients need empathy, support & better usability. 📖 pubmed.ncbi.nlm.nih.gov/40705794/ #TB #mHealth #DigitalHealth https://pubmed.ncbi.nlm.nih.gov/40705794/10 Oct 2025 14:38 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m2tvjkgzdc2ihttps://bsky.app/profile/mtbi.bsky.social/post/3m2r3cynao22s🩺New study compares 4R10 vs 2R20 regimens for latent TB. No major cost difference, but meds + follow-ups are biggest drivers. Fewer visits could cut costs, depending on setting. 🔗 pubmed.ncbi.nlm.nih.gov/40980570/ #TB #TPT #GlobalHealth #PublicHealth https://pubmed.ncbi.nlm.nih.gov/40980570/09 Oct 2025 11:44 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m2r3cynao22shttps://bsky.app/profile/mtbi.bsky.social/post/3m2mavpbeic2u🧬 TB remains one of the world’s top infectious killers. Where, in your opinion, should innovation funding go next? 🟦 Diagnostics 🟦 Shorter treatments 🟦 Vaccines 🟦 Health systems 🌐 Read the WHO Global TB Report 2024: https://www.who.int/teams/global-programme-on-tuberculosis-and-lung-health/tb-reports/global-tuberculosis-report-2024 #TB #GlobalHealth #InfectiousDiseases #WHO07 Oct 2025 13:40 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m2mavpbeic2uhttps://bsky.app/profile/mtbi.bsky.social/post/3m255qnav5s27🩺 WHO now recommends a 6-month all-oral regimen for drug-resistant TB: shorter, safer, and easier to complete. A major step forward in global TB care. 📄 Full update: https://www.who.int/news/item/15-04-2025-who-announces-landmark-changes-in-treatment-of-drug-resistant-tuberculosis #TB #GlobalHealth01 Oct 2025 13:34 +0000at://did:plc:bvbjjqak5st2e3qlofwovfu2/app.bsky.feed.post/3m255qnav5s27