The open access journal of the ISHR The journal aims to publish fundamental and translational research that advances knowledge of the mechanisms responsible for both normal and diseased cardiovascular function https://bsky.app/profile/jmccplus.bsky.socialhttps://bsky.app/profile/jmccplus.bsky.social/post/3megf5pf7ac2cStuck between a ROCK2 and a hard place? New research just out shows selective ROCK2 inhibition reduces microvascular obstruction after myocardial I/R but doesn’t limit infarct size. Highlights distinct roles for ROCK isoforms in #cardioprotection. 🫀 https://www.sciencedirect.com/science/article/pii/S2772976126000036 #CardioSky09 Feb 2026 11:52 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3megf5pf7ac2chttps://bsky.app/profile/jmccplus.bsky.social/post/3me4diylyg223🫀New research demonstrates that high-throughput, label-free optical oxygen measurements can assess adrenergic effects in iPSC-derived #cardiomyocytes Paired with all-optical #electrophysiology, this enables scalable, human-based preclinical testing #CardioSky https://www.sciencedirect.com/science/article/pii/S2772976126000012?via%3Dihub05 Feb 2026 11:56 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3me4diylyg223https://bsky.app/profile/jmccplus.bsky.social/post/3mbwr3tz24c2x🫀🦠 How does #COVID19 damage the heart? New research from Gross et al. using human iPSC-derived #cardiomyocytes uncovers cellular responses to SARS-CoV-2, shedding light on mechanisms of cardiac injury. https://www.sciencedirect.com/science/article/pii/S277297612500552508 Jan 2026 19:53 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3mbwr3tz24c2xhttps://bsky.app/profile/jmccplus.bsky.social/post/3ma6thxlotk2i💓 New research from Achlaug et al. @technion.bsky.social reveals how cancer-driven cytokine signalling improves cardiac function and reduces fibrosis. Tumour–heart crosstalk with major therapeutic implications https://www.sciencedirect.com/science/article/pii/S2772976125002120 #CardioOncology #Immunology #Fibrosis #Research17 Dec 2025 14:07 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3ma6thxlotk2ihttps://bsky.app/profile/jmccplus.bsky.social/post/3m7kgu3jzp22f🚨 New paper alert! Feder et al. have recently shown that persistently increased #CaMKIIδ autophosphorylation drives pathological sarcoplasmic reticulum #calcium loss in a murine model of #doxorubicin-induced #cardiomyopathy. 💔 ➡️📉 Check it out: https://www.sciencedirect.com/science/article/pii/S2772976125005471#bi000509 Dec 2025 11:27 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m7kgu3jzp22fhttps://bsky.app/profile/jmccplus.bsky.social/post/3m6wdawgjcs2pRab10 to the rescue! 🦸‍♂️🫀! New study from Xu et al. in the December issue shows how this tiny protein helps keep harmful heart growth in check. Read more at: https://www.sciencedirect.com/science/article/pii/S2772976125002132 #CardioProtection #Hypertrophy #CardioSky01 Dec 2025 11:30 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m6wdawgjcs2phttps://bsky.app/profile/jmccplus.bsky.social/post/3m6jtzsfbes2y🧪 Just out: a new #review of Rac1-driven signalling in cardiomyocytes — covering #hypertrophy, #arrhythmia and #redox stress. A must-read for anyone in cardiac research! 💙 #Cardiology #HeartResearch #SignalTransduction #CardioSky https://www.sciencedirect.com/science/article/pii/S2772976125005458?via%3Dihub26 Nov 2025 12:25 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m6jtzsfbes2yhttps://bsky.app/profile/jmccplus.bsky.social/post/3m52gendip222On your way to #AHA or just looking for some weekend reading? Check out the latest paper from Warren et al who uncovered region-specific metabolic and signalling changes in the endocardium vs epicardium in a mini-pig model of #HCM 🫀🫀 https://sciencedirect.com/science/article/pii/S2772976125002144 #CardioSky #AnimalModel07 Nov 2025 15:46 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m52gendip222https://bsky.app/profile/jmccplus.bsky.social/post/3m4q2jea7sk2tNew work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology https://sciencedirect.com/science/article/pii/S2772976125002065 #CardioSky03 Nov 2025 12:47 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m4q2jea7sk2thttps://bsky.app/profile/jmccplus.bsky.social/post/3m4g4c4ydws22We often treat #diabetes and #heart #disease separately — but they’re connected🫀. A recent study from Srinivas, Alluri et al. shows that removing CHOP in β-cells protects against both metabolic dysfunction and cardiac fibrosis in T2D mice. https://sciencedirect.com/science/article/pii/S2772976125002119 #CardioSky #NewPaper30 Oct 2025 13:52 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m4g4c4ydws22https://bsky.app/profile/jmccplus.bsky.social/post/3m475api2522v🫀 New in JMCC Plus! Age, sex & vessel region shape vasomotor function in the descending thoracic #aorta — with #endothelial integrity & relaxation declining with age. Want to know more- check out Saemann et al.: https://sciencedirect.com/science/article/pii/S2772976125002107 #CardioSky @jmccardiology.bsky.social27 Oct 2025 19:21 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m475api2522vhttps://bsky.app/profile/jmccplus.bsky.social/post/3m3ukhhfouc2fNew work from Nicole S. York and the group of Leigh Anne Swayne at the University of Victoria charts how #H9c2 heart cells change shape, signal, & express genes during differentiation—revealing both their promise & limits as #cardiomyocyte models. #CardioSky https://sciencedirect.com/science/article/pii/S277297612500205323 Oct 2025 14:18 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m3ukhhfouc2fhttps://bsky.app/profile/jmccplus.bsky.social/post/3m3ezrld2rs2jEver wondered how #Calcium channels cluster in #iPSC derived #Cardiomyocytes? New work just published from Schwenzer et al. should put your mind at rest as they investigated just that! Check out the latest paper for more information https://www.sciencedirect.com/science/article/pii/S2772976125002090?via%3Dihub #CardioSky https://sciencedirect.com/science/article/pii/S2772976125002090?dgcid=raven_sd_aip_email17 Oct 2025 10:09 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m3ezrld2rs2jhttps://bsky.app/profile/jmccplus.bsky.social/post/3m2c3em3ops25Looking for some weekend reading? 📜 New work from from the University of Ottawa Heart Institute, show how metabolic substrates regulate effects of Wnt/β-catenin signaling in #cardiomyocytes, specifically affecting regulation of #Connexin43 https://sciencedirect.com/science/article/pii/S277297612500207703 Oct 2025 12:35 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3m2c3em3ops25https://bsky.app/profile/jmccplus.bsky.social/post/3lydhdcgtnc2rNew work out in the from @ox.ac.uk looks into developing sex-specific human ventricular #electromechanical multiscale models. Given the importance of #biologicalsex in #CardiovascularHealth this could be a very important tool! https://sciencedirect.com/science/article/pii/S2772976125001989 #CardioSky08 Sep 2025 14:51 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lydhdcgtnc2rhttps://bsky.app/profile/jmccplus.bsky.social/post/3lw72jeb7dz2r🧬 New pig models of neonatal #HCM show severe cardiac #hypertrophy and perinatal lethality from MYBPC3 and MYH7 mutations. Pigs were highly sensitive to sarcomeric gene disruption, developing severe HCM, suggesting they may not be ideal genetic models. 🔗 https://www.sciencedirect.com/science/article/pii/S277297612500176X12 Aug 2025 10:01 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lw72jeb7dz2rhttps://bsky.app/profile/jmccplus.bsky.social/post/3lvuyp3buqg2u12-week-old #ob/ob mice show mild DCM with no major structural changes in #MAMs. Proteins linked to lipid metabolism and stress response were increased in MAMs, while hypoxic stress triggered more cardiomyocyte death. https://www.sciencedirect.com/science/article/pii/S277297612500172208 Aug 2025 10:01 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lvuyp3buqg2uhttps://bsky.app/profile/jmccplus.bsky.social/post/3lvtaobvy2c2nNew paper out in our September issue from Bass-Stringer and colleagues @bakerresearchau.bsky.social looking at PI3K. Exploring a new #genetherapy to improve heart function in mice and sheep. https://sciencedirect.com/science/article/pii/S2772976125001977 #CardioSky07 Aug 2025 17:19 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lvtaobvy2c2nhttps://bsky.app/profile/jmccplus.bsky.social/post/3lvpxqqtsou2cCalling all #immunofluorescence scientists! Teng et al. showed glyoxal enhances IF signal and co-localisation while reducing staining artifacts, making it a superior alternative to PFA in murine cardiac tissue research. https://www.sciencedirect.com/science/article/pii/S277297612500173406 Aug 2025 10:01 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lvpxqqtsou2chttps://bsky.app/profile/jmccplus.bsky.social/post/3lvauwzezzl22📈 Circulating adropin is linked to higher risk of #AKI in patients with acutely decompensated #heartfailure (#ADHF) after decongestive therapy. It outperformed conventional biomarkers like urinary ACR and NT-proBNP. #CardioRenal #Biomarkers https://www.sciencedirect.com/science/article/pii/S277297612500021231 Jul 2025 10:01 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lvauwzezzl22https://bsky.app/profile/jmccplus.bsky.social/post/3lv3ssmbuoj2tKazantzi et al show that #MEK–ERK1/2 and #PKC pathways independently and synergistically modulate ETB receptor upregulation under flow cessation. These signalling axes may be promising targets for #cerebrovascular disease. Read more here! https://www.sciencedirect.com/science/article/pii/S277297612500019429 Jul 2025 09:40 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lv3ssmbuoj2thttps://bsky.app/profile/jmccplus.bsky.social/post/3lsr6afi36k2pNew work just out from Fowler et al, invesigated the role of subthreshold #DADs on arrhythmia generation in #CPVT! Congrats to the Authors! https://sciencedirect.com/science/article/pii/S2772976125001850 #CardioSky29 Jun 2025 17:14 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lsr6afi36k2phttps://bsky.app/profile/jmccplus.bsky.social/post/3lsiunxmo762kNIH-funded and need to publish in an open-access journal? JMCC Plus is fully OA and we're offering a 50% APC discount until 30 Sept 2025! Submit your work and join our growing community of cardiovascular researchers. #OpenAccess #Cardiac #Research https://www.sciencedirect.com/journal/journal-of-molecular-and-cellular-cardiology-plus/about/aims-and-scope26 Jun 2025 10:02 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lsiunxmo762khttps://bsky.app/profile/jmccplus.bsky.social/post/3lsbdb34qg52kNew in JMCC Plus: This study presents a multidimensional analysis to investigate culture-induced alterations in living #myocardial slices, demonstrating structural integrity despite changes to slices’ functional and #molecular profiles Read more here! https://www.sciencedirect.com/science/article/pii/S277297612500184923 Jun 2025 10:02 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lsbdb34qg52khttps://bsky.app/profile/jmccplus.bsky.social/post/3ls2btf3caw2kExciting news! Clarivate has released the inaugural #ImpactFactor for 2024, and JMCC Plus, just 3 years since its launch, has earned a spot in Q2! A huge thank you to our authors, reviewers, and readers for helping us reach this milestone. #AcademicPublishing #JMCCPlus20 Jun 2025 14:47 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3ls2btf3caw2khttps://bsky.app/profile/jmccplus.bsky.social/post/3lrpuzu7yfs2hHeart failure alters organelle dynamics. Latchman et al. reveal striking shifts in failing cardiomyocytes- more rounded #mitochondria, disrupted SR-mitochondria juxtaposition and altered lipid droplet size across #heart #failure types . https://www.sciencedirect.com/science/article/pii/S2772976125001801 ‪@upenn.edu @temple.edu‬16 Jun 2025 11:32 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lrpuzu7yfs2hhttps://bsky.app/profile/jmccplus.bsky.social/post/3lrdda7qudk2vNew #CardioBreakthrough: Gemfibrozil—beyond lipid-lowering—blocks caspase‑11‑driven pyroptosis in mouse hearts, reducing infarct size during ischemia/reperfusion. A promising repurposed therapy post-#AMI! Congratulations to all authors. Want to know more? https://www.sciencedirect.com/science/article/pii/S277297612500011X11 Jun 2025 11:41 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lrdda7qudk2vhttps://bsky.app/profile/jmccplus.bsky.social/post/3lqf7hx5j2c27Looking for some weekend reading? We recently published some work from Chambers et al. looking at the effect of an #SGLT2i on #mitochondrial function from non-diabetic mice with #Cardiomyopathy Accompanied by a very nice editorial! https://sciencedirect.com/science/article/pii/S277297612500015730 May 2025 12:14 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lqf7hx5j2c27https://bsky.app/profile/jmccplus.bsky.social/post/3lpjmri3qd22yAre you looking for a new model of arrhythmia? Maybe performance horses are the answer! Great work just out from Avison et al! https://www.sciencedirect.com/science/article/pii/S277297612500171019 May 2025 12:58 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3lpjmri3qd22yhttps://bsky.app/profile/jmccplus.bsky.social/post/3loxqrwscd52iThe JMCC and JMCC Plus Reception is in full swing at #ISHR World Congress 2025! A great opportunity to bring our editorial team and reviewers together, while hearing from JMCC #EiC Rong Tian and JMCC Plus #EiC @davorpavlovic.bsky.social12 May 2025 10:22 +0000at://did:plc:ctixsoe4zyitrdaluce4sl4m/app.bsky.feed.post/3loxqrwscd52i