https://bsky.app/profile/hp746.bsky.socialhttps://bsky.app/profile/hp746.bsky.social/post/3mvbroxznds2mAntimicrobial lock therapy reduced CRBSI risk by 63% in hemodialysis patients https://pmc.ncbi.nlm.nih.gov/articles/PMC12713221/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social12 Sep 2026 00:02 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mvbroxznds2mhttps://bsky.app/profile/hp746.bsky.social/post/3mv7orcfnpc2iFor CDI, fidaxomicin is preferred as first-line therapy for nonfulminant disease (oral vancomycin as acceptable alternative) https://www.cghjournal.org/article/S1542-3565(26)00358-7/fulltext #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social11 Sep 2026 04:04 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mv7orcfnpc2ihttps://bsky.app/profile/hp746.bsky.social/post/3mv4uxiwa3k2aPurulent SSTIs produce pus because Staphylococcus aureus triggers an intense neutrophilic inflammatory response, leading to tissue destruction and abscess formation. https://pmc.ncbi.nlm.nih.gov/articles/PMC7931029/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social10 Sep 2026 01:17 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mv4uxiwa3k2ahttps://bsky.app/profile/hp746.bsky.social/post/3mv2g5brxvc2oCOSMOS study found that 12 weeks of simeprevir + sofosbuvir achieved high cure rates in patients with genotype 1 HCV https://pmc.ncbi.nlm.nih.gov/articles/PMC5612775/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social09 Sep 2026 01:46 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mv2g5brxvc2ohttps://bsky.app/profile/hp746.bsky.social/post/3muplh5exs22xAGEP is most commonly drug-induced, particularly by systemic antibiotics such as beta-lactams, with a medianly rapid onset and frequent fever. https://pmc.ncbi.nlm.nih.gov/articles/PMC8780223/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social04 Sep 2026 18:22 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3muplh5exs22xhttps://bsky.app/profile/hp746.bsky.social/post/3munnxpejwk24In 2018, first CRISPR-edited babies were born, rising controversy because the genetic modifications were not proven safe or necessary and could cause unintended effects. https://pmc.ncbi.nlm.nih.gov/articles/PMC6724388/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social04 Sep 2026 00:02 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3munnxpejwk24https://bsky.app/profile/hp746.bsky.social/post/3mukx3iixjk2sBLING III trial- continuous infusion of pip-tazo or meropenem did not significantly reduce 90-day mortality but improved clinical cure rates in critically ill patients with sepsis https://jamanetwork.com/journals/jama/fullarticle/2819971 #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social02 Sep 2026 22:07 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mukx3iixjk2shttps://bsky.app/profile/hp746.bsky.social/post/3muie5u2cfk2kPAT (such as liposomal ampho B, voriconazole, or caspofungin) reduced antifungal use and costs without increasing IFI-related mortality compared to empiric in AL patients. https://pmc.ncbi.nlm.nih.gov/articles/PMC13308701/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social01 Sep 2026 21:23 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3muie5u2cfk2khttps://bsky.app/profile/hp746.bsky.social/post/3mugajql7ks2ySerratia marcescens can acquire multiple resistance mechanisms, making accurate identification and infection-control measures particularly important in hospitalized patients https://journals.asm.org/doi/10.1128/cmr.00017-11 #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social01 Sep 2026 01:13 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mugajql7ks2yhttps://bsky.app/profile/hp746.bsky.social/post/3mu6j2gaiks2mIn a 20-patient case series, oral vancomycin 125 mg once daily for ≥8 weeks effectively prevented recurrent C. difficile in elderly patients with multiple relapses. https://link.springer.com/article/10.1186/s12879-019-3676-1 #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social28 Aug 2026 23:24 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mu6j2gaiks2mhttps://bsky.app/profile/hp746.bsky.social/post/3mu3xzvkr7k2gThe STROBE guidelines provide a 22-item checklist to improve the clarity, completeness, and critical appraisal of observational research. https://pmc.ncbi.nlm.nih.gov/articles/PMC6398292/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social https://pmc.ncbi.nlm.nih.gov/articles/PMC6398292/?utm_source=chatgpt.com27 Aug 2026 23:14 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mu3xzvkr7k2ghttps://bsky.app/profile/hp746.bsky.social/post/3mtzxhovqdc2tMAT2203 is an investigational oral amphotericin B formulation to reduce the nephrotoxicity and IV burden of conventional amphotericin B. This shows 5 compassionate-use patients cases. https://academic.oup.com/ofid/article/11/7/ofae346/7697995 #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social27 Aug 2026 03:59 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mtzxhovqdc2thttps://bsky.app/profile/hp746.bsky.social/post/3mtxfn7jv2c2cGlucocorticoids suppress many neutrophil inflammatory functions but also prolong neutrophil survival by delaying apoptosis. https://www.mdpi.com/1422-0067/19/12/4090 #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social26 Aug 2026 03:34 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mtxfn7jv2c2chttps://bsky.app/profile/hp746.bsky.social/post/3mtugwje35c2kCROI 2024 phase I trial showed ultra-long-acting cabotegravir showed a longer half-life, better tolerability, and potential for every-4-month dosing compared with current cabotegravir. https://www.aidsmap.com/news/mar-2024/ultra-long-acting-cabotegravir-could-be-taken-three-times-year-hiv-prep-and-treatment #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social24 Aug 2026 23:19 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mtugwje35c2khttps://bsky.app/profile/hp746.bsky.social/post/3mtmerxmv2s22NCC can mimic tumors on imaging. The patient was initially misdiagnosed with meningioma but had NCC. Treatment with albendazole, prednisolone, and phenytoin led to full recovery. https://www.cureus.com/articles/46107-neurocysticercosis-an-easy-to-miss-diagnosis-in-non-endemic-regions#!/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social21 Aug 2026 18:20 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mtmerxmv2s22https://bsky.app/profile/hp746.bsky.social/post/3mtlbdpycrs25Daptomycin-induced DRESS syndrome and eosinophilic pneumonia can mimic conditions such as viral pneumonitis. Promptly d/c daptomycin and give high-dose corticosteroids when indicated. https://www.cureus.com/articles/335374-a-diagnostic-dilemma-daptomycin-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-and-eosinophilic-pneumonia-with-concurrent-covid-19#!/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social21 Aug 2026 07:45 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mtlbdpycrs25https://bsky.app/profile/hp746.bsky.social/post/3mthxeoyeac2j16S rRNA sequencing identifies bacterial DNA. Its long turnaround time limits clinical use. May be useful for culture-negative infections or pathogens that are difficult to culture. https://journals.asm.org/doi/10.1128/spectrum.02094-22 #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social20 Aug 2026 00:09 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mthxeoyeac2jhttps://bsky.app/profile/hp746.bsky.social/post/3mtf4tpvdic2jCAP overdiagnosis was common among older adults and those presenting with dementia or AMS. Unnecessary full-course antibiotics expose these patients to more ADE (risk >>> benefits) https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2816759 #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social18 Aug 2026 21:09 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mtf4tpvdic2jhttps://bsky.app/profile/hp746.bsky.social/post/3mtd5vodzfs2zbNAbs target conserved HIV regions but are limited by resistance and delivery challenges. Gene-based and combination therapies may improve their potential. https://link.springer.com/article/10.1007/s11904-025-00744-1 #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social18 Aug 2026 02:23 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mtd5vodzfs2zhttps://bsky.app/profile/hp746.bsky.social/post/3msw5ptgh222qESR has decent accuracy for diagnosing DFO and may be useful as an initial screening tool, but it should not be used alone to confirm or rule out osteomyelitis. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1660465/full #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social12 Aug 2026 22:15 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3msw5ptgh222qhttps://bsky.app/profile/hp746.bsky.social/post/3mstktnebt22rPivmecillinam has been used in EU for 40+ years but was only recently FDA-approved in 2024. Reanalyzed 14 EU trial data using current FDA criteria, supporting its efficacy. https://pmc.ncbi.nlm.nih.gov/articles/PMC12728296/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social11 Aug 2026 21:31 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mstktnebt22rhttps://bsky.app/profile/hp746.bsky.social/post/3msr3qqh2ec2rDaptomycin+Ceftaroline led to fewer treatment failures than standard therapy (20%vs43%) for MRSA, however it just missed statistical significance (p=0.052). #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social www.clinicalkey.com#!/content/pl... https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0924857921000406?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0924857921000406%3Fshowall%3Dtrue&referrer=https:%2F%2Fpubmed.ncbi.nlm.nih.gov%2F10 Aug 2026 21:56 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3msr3qqh2ec2rhttps://bsky.app/profile/hp746.bsky.social/post/3msjht65guk24Fluoroquinolones can prolong QT and increase TdP risk. Moxifloxacin should be avoided in patients with QT risk factors, while ciprofloxacin and levofloxacin require caution. www.sciencedirect.com/science/arti... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social https://www.sciencedirect.com/science/arti..07 Aug 2026 21:11 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3msjht65guk24https://bsky.app/profile/hp746.bsky.social/post/3mshjvhoxhc2mIn neonatal sepsis, a short course of ceftriaxone does not have a higher incidence of hyperbilirubinemia compared to a short course of cefotaxime (has been d/c'd in the U.S.) https://jppt.kglmeridian.com/view/journals/jppt/26/1/article-p99.xml #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social07 Aug 2026 02:43 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mshjvhoxhc2mhttps://bsky.app/profile/hp746.bsky.social/post/3msemljmnzc2mDiabetes worsens bacterial infections through hyperglycemia, impaired immunity, and reduced antibiotic effectiveness, with biofilm formation contributing to treatment challenges. https://pmc.ncbi.nlm.nih.gov/articles/PMC11385445/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social https://pmc.ncbi.nlm.nih.gov/articles/PMC..05 Aug 2026 22:53 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3msemljmnzc2mhttps://bsky.app/profile/hp746.bsky.social/post/3mscfmnnoyk2kWeak inducer/good substrate drugs seem promising, but the hidden AmpD mutants survive and expand, masking the true clinical picture until resistance emerges. https://pmc.ncbi.nlm.nih.gov/articles/PMC3136230/ #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social05 Aug 2026 01:43 +0000at://did:plc:dbd6fcvewvaodjsxmp7g7bie/app.bsky.feed.post/3mscfmnnoyk2k