Post Doc @ Francis Crick Institute and UCL - COPII, CryoCLEM, cats, mammalian secretory pathway, image analysishttps://bsky.app/profile/dr-downes.bsky.socialhttps://bsky.app/profile/dr-downes.bsky.social/post/3lwt7nac7c22tI attended this course last year and cannot recommend it enough! [contains quote post or other embedded content]20 Aug 2025 10:26 +0000at://did:plc:dkl7zuoziftnum6h4m4tk5ko/app.bsky.feed.post/3lwt7nac7c22thttps://bsky.app/profile/dr-downes.bsky.social/post/3lv6wqknvsc2oVery excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! https://www.biorxiv.org/content/10.1101/2025.07.29.667472v1 #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬30 Jul 2025 15:28 +0000at://did:plc:dkl7zuoziftnum6h4m4tk5ko/app.bsky.feed.post/3lv6wqknvsc2ohttps://bsky.app/profile/dr-downes.bsky.social/post/3llh3gq2s222cReady for BBCs #AQuestionofScience here @crick.ac.uk 🔬🧬🥼🧪🦠28 Mar 2025 15:01 +0000at://did:plc:dkl7zuoziftnum6h4m4tk5ko/app.bsky.feed.post/3llh3gq2s222chttps://bsky.app/profile/dr-downes.bsky.social/post/3ll7bxnoo5s2dI am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com. Check it out here! rdcu.be/eeY1J #COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES https://rdcu.be/eeY1J25 Mar 2025 12:37 +0000at://did:plc:dkl7zuoziftnum6h4m4tk5ko/app.bsky.feed.post/3ll7bxnoo5s2dhttps://bsky.app/profile/dr-downes.bsky.social/post/3ljsf2lrqqc2iDoes anyone have any idea what this wavey guy is? 🌊🌊🌊🌊#TeamTomo #CryoET In-situ tomogram of milled RPE-1 cells.07 Mar 2025 16:02 +0000at://did:plc:dkl7zuoziftnum6h4m4tk5ko/app.bsky.feed.post/3ljsf2lrqqc2ihttps://bsky.app/profile/dr-downes.bsky.social/post/3lbzklfa4vc2oLets play... What Am I Looking At?? Low mag tomogram of milled RPE-1s. Any guesses of whats going on here? #TeamTomo Prize? idk... bragging rights? The feeling of superiority? I'll collect a high mag tomo tomorrow, so the answer may actually be revealed! (mysteries mysteries mysteries).28 Nov 2024 17:08 +0000at://did:plc:dkl7zuoziftnum6h4m4tk5ko/app.bsky.feed.post/3lbzklfa4vc2ohttps://bsky.app/profile/dr-downes.bsky.social/post/3lbtygn3mlc2eLatest paper from our lab out now! #TeamTomo #CryoET https://www.nature.com/articles/s41594-024-01413-426 Nov 2024 12:00 +0000at://did:plc:dkl7zuoziftnum6h4m4tk5ko/app.bsky.feed.post/3lbtygn3mlc2ehttps://bsky.app/profile/dr-downes.bsky.social/post/3lbkersrkv22vHmmm something tells me #cryoCARE didn't quite work...🤔 #CryoET #TeamTomo22 Nov 2024 16:15 +0000at://did:plc:dkl7zuoziftnum6h4m4tk5ko/app.bsky.feed.post/3lbkersrkv22v