The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924https://bsky.app/profile/jci.orghttps://bsky.app/profile/jci.org/post/3muub4gwp3h2oICYMI: Robert A. Koeth & team report on a link between diet, the #GutMicrobiome and #AFib: https://doi.org/10.1172/JCI201684 ✅ Integration of a large clinical dataset (>5000) ✅ Rigorous animal modeling ✅ Thorough metagenomics06 Sep 2026 15:00 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3muub4gwp3h2ohttps://bsky.app/profile/jci.org/post/3museqnw5n72lSaturday Highlight💫: How might we muscle through #sarcopenia as we age? https://doi.org/10.1172/JCI190646 W. David Arnold & team explored muscle function in aged rodents, identifying NMJ deficits and a potential therapeutic strategy to improve muscle function in #aging. @tomgillingwater.bsky.social05 Sep 2026 21:00 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3museqnw5n72lhttps://bsky.app/profile/jci.org/post/3mupueg7mpi2hAlpha-Gal syndrome is a tick bite-associated allergy characterized by reactions to alpha-Gal found in red meat https://doi.org/10.1172/JCI192370 Peter D. Crompton & team show the potential of alpha-Gal-specific mAbs to prevent the allergy by blocking IgE binding to alpha-Gal. @the-asci.org04 Sep 2026 21:02 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mupueg7mpi2hhttps://bsky.app/profile/jci.org/post/3munduiq27f26Genetic mapping of monocyte fate decisions following myocardial infarction: https://doi.org/10.1172/JCI209791 Sakalli et al. provide a Commentary on Koenig et al.: https://doi.org/10.1172/JCI18968403 Sep 2026 21:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3munduiq27f26https://bsky.app/profile/jci.org/post/3mumptlbr2v2tEarly signals shape cardiac macrophage phenotypes & repair outcomes: https://doi.org/10.1172/JCI189684 Kory J Lavine & team traced monocyte differentiation trajectories after injury & identified an MHCIIhi population with an early IFN response signature associated with enhanced cardioprotection @the-asci.org03 Sep 2026 15:03 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mumptlbr2v2thttps://bsky.app/profile/jci.org/post/3muktfpck732mFueling fibrosis: BCAT1 links branched-chain amino acid metabolism to collagen production: https://doi.org/10.1172/JCI209543 Marco Ronfini & John W. Elrod comment on Takizawa et al.: https://doi.org/10.1172/JCI182216 #Fibrosis02 Sep 2026 21:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3muktfpck732mhttps://bsky.app/profile/jci.org/post/3mukdfhbodu2kBCAT1 provides building blocks for cardiac fibrogenesis: https://doi.org/10.1172/JCI182216 Michio Nakaya & team reveal how activated cardiac fibroblasts meet the high demand for proline in collagen synthesis. The image shows Bcat1 and Col1a1 mRNA expression in the infarcted mouse heart. #CardiacFibrosis02 Sep 2026 16:15 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mukdfhbodu2khttps://bsky.app/profile/jci.org/post/3muk7dlcujl2sHow might we muscle through sarcopenia as we age? https://doi.org/10.1172/JCI190646 W. David Arnold & team explored muscle function in aged rodents, identifying neuromuscular junction deficits and a potential therapeutic strategy to improve muscle function in aging. @tomgillingwater.bsky.social02 Sep 2026 15:02 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3muk7dlcujl2shttps://bsky.app/profile/jci.org/post/3muicw65ed52xRobert A. Koeth & team report on a link between diet, the #GutMicrobiome and #AtrialFibrillation: https://doi.org/10.1172/JCI201684 ✅ Integration of a large clinical dataset (>5000) ✅ Rigorous animal modeling ✅ Thorough metagenomics01 Sep 2026 21:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3muicw65ed52xhttps://bsky.app/profile/jci.org/post/3muhswrducu2mThe multiple faces of γδ T cells in cancer This issue’s cover: Bolini et al reviews the complex biology of γδT cells & describe current attempts to harness the cell type for cancer therapy. A unique T cell subset can restrain or support cancer progression: https://doi.org/10.1172/JCI209159 Photo by L Galluzzi01 Sep 2026 16:15 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3muhswrducu2mhttps://bsky.app/profile/jci.org/post/3muf6h4b4ot2dDo the math: modernizing the FDA’s evidence paradigm for precision medicine: https://doi.org/10.1172/JCI211143 In this Viewpoint, Peter J. Pitts @peterpitts.bsky.social et al. discuss “dominator collapse” as a reality for modern drug development #FutureOfMedicine #RareDisease31 Aug 2026 15:03 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3muf6h4b4ot2dhttps://bsky.app/profile/jci.org/post/3mucnvm6n6v2mWeekend spotlight💫: Reproductive life after In vitro fertilization: https://doi.org/10.1172/JCI210577 JCI Associate Editor Serdar E. Bulun discusses what the observations in mouse models from Rhon-Calderon et al. (https://doi.org/10.1172/JCI201633) might mean for human offspring born with #IVF assistance.30 Aug 2026 15:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mucnvm6n6v2mhttps://bsky.app/profile/jci.org/post/3mu7woost4c2mWorth another look💫: This study describes a promising therapeutic strategy for advanced prostate cancer: https://doi.org/10.1172/JCI203835 Karen Cichowski & team find a combo treatment (that suppresses epigenetic and oncogenic enzymes), can trigger metabolic collapse of tumors in CRPC models.29 Aug 2026 13:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mu7woost4c2mhttps://bsky.app/profile/jci.org/post/3mu5mz7arzj2iA dual mechanism for immunosuppression in pancreatic cancer: https://doi.org/10.1172/JCI197733 Hussain et al. find extracellular vesicles produced by pancreatic tumor cells modulate non-tumoral cells behavior (involving ALOX15b+ macrophages and SFRP1+ CAFs) to foster an immunosuppressive ecosystem.28 Aug 2026 15:02 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mu5mz7arzj2ihttps://bsky.app/profile/jci.org/post/3mu34kcp3dh2iUncovering the backbone of disc degeneration Cao Yang & team discover PRMT2 deficiency‒mediated methylation-ubiquitination crosstalk of MED12 promotes R-loop/cGAS/STING axis-dependent progression of Intervertebral disc degeneration: https://doi.org/10.1172/JCI197274 #IVDD #BackPain27 Aug 2026 15:02 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mu34kcp3dh2ihttps://bsky.app/profile/jci.org/post/3mtza5gx7h52iReproductive life after In vitro fertilization: https://doi.org/10.1172/JCI210577 JCI Editor Serdar E. Bulun discusses what the observations in mouse models from Rhon-Calderon et al. (https://doi.org/10.1172/JCI201633) might mean for human offspring born with IVF assistance @the-asci.org26 Aug 2026 21:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mtza5gx7h52ihttps://bsky.app/profile/jci.org/post/3mtw3mupg4s24Early ovarian failure in IVF-conceived mice https://doi.org/10.1172/JCI201633 Marisa S. Bartolomei & team report signs of accelerated reproductive aging in female mice conceived via in vitro fertilization, leading to reduced fertility in this model.25 Aug 2026 15:02 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mtw3mupg4s24https://bsky.app/profile/jci.org/post/3mtu76db3hi24This study describes a promising therapeutic strategy for advanced prostate cancer: https://doi.org/10.1172/JCI203835 Karen Cichowski & team find a combo treatment (that suppresses epigenetic and oncogenic enzymes), can trigger metabolic collapse of tumors in CRPC models.24 Aug 2026 21:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mtu76db3hi24https://bsky.app/profile/jci.org/post/3mttl5fe47j2zTargeting the gut microbiome may improve heart transplant outcomes: https://doi.org/10.1172/JCI207999 In this Review, Ivan Ðuran, W. H. Wilson Tang, & Petra Mamic describe the microbiome as a modifiable risk factor in heart failure and heart transplant.24 Aug 2026 15:02 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mttl5fe47j2zhttps://bsky.app/profile/jci.org/post/3mtr2lwcmkg24Weekend read💫: Featured on this issue’s cover, Hao et al. report PTEN deficiency enhances sensitivity to ATR inhibition in preclinical models and clinical trials of high-grade serous ovarian cancer: https://doi.org/10.1172/JCI197645 Image credit: David A. Litman/Shutterstock23 Aug 2026 15:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mtr2lwcmkg24https://bsky.app/profile/jci.org/post/3mtodgdkgqd2zSaturday spotlight💫 : Combining radiotherapy with immunotherapy to improve cancer treatment: https://doi.org/10.1172/JCI207550 In this Review, Lu Lu & Liufu Deng describe the rationale behind using radiotherapy to enhance the response to #cancer #immunotherapy.22 Aug 2026 13:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mtodgdkgqd2zhttps://bsky.app/profile/jci.org/post/3mtmnsmvwux2jMonoclonal antibody CIS43LS sets the bar for long-acting malaria protection: https://doi.org/10.1172/JCI209790 David J. Sullivan @johnshopkinssph.bsky.social provides a Commentary on Tran et al.: https://doi.org/10.1172/JCI20755921 Aug 2026 21:01 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mtmnsmvwux2jhttps://bsky.app/profile/jci.org/post/3mtlzr4lef42bAnti-malaria mAb demonstrates durable protection in African adults https://doi.org/10.1172/JCI207559 Peter D. Crompton & team assessed the phase II trial of CIS43LS, revealing that the long-acting mAb maintained over 80% protection through a single malaria season. @mmv.org @the-asci.org21 Aug 2026 15:02 +0000at://did:plc:dp6fotbhabsloue6hd2bec2s/app.bsky.feed.post/3mtlzr4lef42b