Official Journal of the International Society for Heart Research (ISHR). www.jmcc-online.comhttps://bsky.app/profile/jmccardiology.bsky.socialhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mvajhmkprj2c🆕 in JMCC: snRNA-seq identifies the FN1-SDC4 axis as a driver of epicardial activation in pulmonary hypertension. Epicardial Sdc4 knockdown limits right ventricular remodeling, highlighting a potential therapeutic target 🎯 https://www.jmcc-online.com/article/S0022-2828(26)00096-9/fulltext11 Sep 2026 12:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mvajhmkprj2chttps://bsky.app/profile/jmccardiology.bsky.social/post/3mv5yx6nosi2b🆕 in JMCC: PAI-1 deficiency drives sex-specific cardiac fibrosis after stress. Metformin reduces fibrosis and improves cardiac function in a sex- and stressor-dependent manner, with marked protection in females after AngII ♀️ https://www.jmcc-online.com/article/S0022-2828(26)00094-5/fulltext10 Sep 2026 12:01 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mv5yx6nosi2bhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mv3tfvj5772t🆕 in JMCC: The deubiquitinase OTUD5 promotes pathological cardiac hypertrophy by stabilizing TRAF2 and activating NF-κB and AKT/GSK3β signaling, identifying the OTUD5-TRAF2 axis as a potential therapeutic target🎯 https://www.jmcc-online.com/article/S0022-2828(26)00098-2/fulltext09 Sep 2026 15:16 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mv3tfvj5772thttps://bsky.app/profile/jmccardiology.bsky.social/post/3mujyowp5cp2i🚨 New in JMCC: A KCNH2 mutation alters L-type Ca²⁺ current gating in LQT2 cardiomyocytes. Estradiol corrects key Ca²⁺ current defects and shortens repolarization, yet may paradoxically preserve susceptibility to early afterdepolarizations⚡️ https://www.jmcc-online.com/article/S0022-2828(26)00100-8/fulltext02 Sep 2026 13:03 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mujyowp5cp2ihttps://bsky.app/profile/jmccardiology.bsky.social/post/3muexpe47lx27🆕 in JMCC: In vivo phosphoproteomics maps EGF- and NRG1β-driven ErbB signaling in the adult heart, revealing shared and ligand-specific networks spanning insulin signaling, Ca²⁺ handling, metabolism, and sarcomere regulation🫀 https://www.jmcc-online.com/article/S0022-2828(26)00102-1/fulltext31 Aug 2026 13:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3muexpe47lx27https://bsky.app/profile/jmccardiology.bsky.social/post/3mu5gdgdunq2t🆕 in JMCC: SK channels become functionally active early in human ventricular remodeling despite unchanged expression. Their recruitment depends on Ca²⁺ handling and CaMKII signaling, with implications for SK-targeted AF therapies 💊 https://www.jmcc-online.com/article/S0022-2828(26)00099-4/fulltext28 Aug 2026 13:03 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mu5gdgdunq2thttps://bsky.app/profile/jmccardiology.bsky.social/post/3mtyff5rlsa2t🆕 in JMCC: Low-dose melatonin promotes coronary angiogenesis and improves cardiac function after MI by targeting endothelial LRRC8A and activating AKT/eNOS/HIF1α signaling, revealing a potential strategy for ischemic heart disease 🫀 https://www.jmcc-online.com/article/S0022-2828(26)00104-5/fulltext26 Aug 2026 13:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mtyff5rlsa2thttps://bsky.app/profile/jmccardiology.bsky.social/post/3mtteh53qwy2o🚨 New in JMCC: This Letter to the Editor shows that dietary BCAA availability modifies exercise-induced cardiac growth in male mice, while improved exercise capacity can occur independently of cardiac growth in both sexes ♀️ ♂️ https://www.jmcc-online.com/article/S0022-2828(26)00087-8/fulltext24 Aug 2026 13:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mtteh53qwy2ohttps://bsky.app/profile/jmccardiology.bsky.social/post/3mtlc7porix2n🚨 New in JMCC: The C-terminal peptide of cardiac troponin T binds the thin filament and reduces Ca²⁺ sensitivity, while HCM mutations disrupt these effects, revealing a potential strategy to correct myocardial hyperactivation 💪🏼 https://www.jmcc-online.com/article/S0022-2828(26)00075-1/fulltext21 Aug 2026 08:01 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mtlc7porix2nhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mtgs3rjfjo2p🆕 in JMCC: Quercetin improves cardiac redox balance and antioxidant defenses in diabetic rats but fails to restore mitochondrial respiration, suggesting antioxidant therapy alone may not reverse T2DM-related cardiac bioenergetic dysfunction ⚡️ https://www.jmcc-online.com/article/S0022-2828(26)00097-0/fulltext19 Aug 2026 13:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mtgs3rjfjo2phttps://bsky.app/profile/jmccardiology.bsky.social/post/3mtbria5sqs2z🚨 Please join us for our next ISHR MCI Seminar on Wednesday, September 9 featuring Drs Mingtao Zhao and John Calvert, who will share their latest research🔬🧬🫀 Register today and save your spot! https://us02web.zoom.us/webinar/register/WN_WvnI1BGaT-WPWSGLHXQ8Cw#/registration17 Aug 2026 13:08 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mtbria5sqs2zhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mtbr66vlso2t⭐ Editor's Choice | 🆕 in JMCC: This study uncovers a stepwise mechanism of enhancer activation in plastic vascular smooth muscle cells, revealing how H2A.Z-driven enhancer maturation shapes cell plasticity and vascular remodeling throughout adult life. https://www.jmcc-online.com/article/S0022-2828(26)00062-3/fulltext17 Aug 2026 13:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mtbr66vlso2thttps://bsky.app/profile/jmccardiology.bsky.social/post/3mt27rz4qm62i🆕 in JMCC: Enhancing mitochondrial SK channels restores mitochondrial Ca²⁺ and redox homeostasis, suppresses pro-arrhythmic Ca²⁺ release, and rescues Ca²⁺ cycling in HFpEF cardiomyocytes, highlighting a promising antiarrhythmic strategy⚡️ https://www.jmcc-online.com/article/S0022-2828(26)00063-5/fulltext14 Aug 2026 13:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mt27rz4qm62ihttps://bsky.app/profile/jmccardiology.bsky.social/post/3msv6wcfzwo2e🚨 New in JMCC: This review highlights how single-cell multi-omics and computational approaches are transforming our understanding of cardiac aging, revealing cell type-specific remodeling and new therapeutic targets in aging hearts 💊 ❤️‍🩹 https://www.jmcc-online.com/article/S0022-2828(26)00064-7/fulltext12 Aug 2026 13:03 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3msv6wcfzwo2ehttps://bsky.app/profile/jmccardiology.bsky.social/post/3msq5ukx5ik2h🆕 in JMCC: L-menthol protects cardiomyocytes from lipid overload by preserving TRPM8 signaling, mitochondrial Ca²⁺ homeostasis, and mitochondrial function. Stabilizing TRPM8 may represent a new therapeutic strategy for metabolic heart disease🫀 https://www.jmcc-online.com/article/S0022-2828(26)00061-1/fulltext10 Aug 2026 13:01 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3msq5ukx5ik2hhttps://bsky.app/profile/jmccardiology.bsky.social/post/3msimhz6kec23🚨 New in JMCC: Integrated single-cell multi-omics identifies fibroblast-like smooth muscle cells as a progenitor-like population driving aortic aneurysm progression through a KAT5-mediated metabolism-epigenetic axis regulating phenotypic switching 🧬 https://www.jmcc-online.com/article/S0022-2828(26)00073-8/fulltext07 Aug 2026 13:01 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3msimhz6kec23https://bsky.app/profile/jmccardiology.bsky.social/post/3msgrmtwx622n🆕 in JMCC: A CRISPR-generated non-phosphorylatable phospholamban (PLB) mouse model reveals that PLB phosphorylation is essential for a full adrenergic response, preserving SR Ca²⁺ load, Ca²⁺ reuptake, and excitation-contraction coupling ⚡️ https://www.jmcc-online.com/article/S0022-2828(26)00060-X/fulltext06 Aug 2026 19:28 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3msgrmtwx622nhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mqccs63hq22qNew in JMCC! Zu and colleagues uncover the functional divergence of hoxb5 paralogues, identifying hoxb5a as the dominant regulator of cardiac morphogenesis and calcium handling in vertebrate heart development. https://www.jmcc-online.com/article/S0022-2828(26)00054-4/abstract10 Jul 2026 14:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mqccs63hq22qhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mqan6ha4xg2mNew in JMCC! Phosphorylation of βIII-tubulin at Ser172 restores microtubule network organization and protects against arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy cardiomyopathy. https://www.jmcc-online.com/article/S0022-2828(26)00055-6/fulltext09 Jul 2026 22:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mqan6ha4xg2mhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mq7sc7wlto2qNew in JMCC! A five small molecule cocktail (5SM) promotes cardiac regeneration post-MI via activation of the DYRK1B–PKA–CREB–TGFβ/BMP signaling axis. https://www.jmcc-online.com/article/S0022-2828(26)00053-2/abstract09 Jul 2026 14:01 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mq7sc7wlto2qhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mq64nlqm4i2nNew in JMCC! Transient expression of OCT4, SOX2, and KLF4 enhances post-MI cardiac regeneration by promoting cardiomyocyte dedifferentiation. https://www.jmcc-online.com/article/S0022-2828(26)00056-8/abstract08 Jul 2026 22:01 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mq64nlqm4i2nhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mq5bwb2fbb2iNew in JMCC! This review provides an overview of the mechanisms linking metabolic syndrome to cardiovascular disease and emerging therapeutic strategies to reduce cardiovascular risk. https://www.jmcc-online.com/article/S0022-2828(26)00058-1/abstract08 Jul 2026 14:03 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mq5bwb2fbb2ihttps://bsky.app/profile/jmccardiology.bsky.social/post/3mq3m4nrhfl23New in JMCC! Lycorine hydrochloride attenuates neointimal hyperplasia and suppresses PDGF-BB-induced vascular smooth muscle cell phenotypic switching via a MAPK-dependent mechanism. https://www.jmcc-online.com/article/S0022-2828(26)00059-3/fulltext07 Jul 2026 22:00 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mq3m4nrhfl23https://bsky.app/profile/jmccardiology.bsky.social/post/3mq3e6pdwhb2aNew in JMCC! Contrary to preclinical models, JPH2 protein abundance is not reduced in failing human hearts despite significant T-tubule remodeling, highlighting the need for human tissue-based validation of candidate therapeutic targets. https://www.jmcc-online.com/article/S0022-2828(26)00057-X/fulltext07 Jul 2026 19:38 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mq3e6pdwhb2ahttps://bsky.app/profile/jmccardiology.bsky.social/post/3moxe56a3rk25🆕in JMCC: Peroxisomes are critical regulators of lipid metabolism, redox balance, & cellular homeostasis, yet their roles in the 🫀 remain underexplored. This review by Rungreang et al highlights emerging evidence linking peroxisomes to cardiac health and disease https://www.jmcc-online.com/article/S0022-2828(26)00041-6/fulltext23 Jun 2026 12:01 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3moxe56a3rk25https://bsky.app/profile/jmccardiology.bsky.social/post/3moutpnnlyl2q🆕 in JMCC: Roman et al. uncover a mechanism underlying sex differences in cardiac ischemia/reperfusion injury. Increased S-nitrosylation of MCU in female hearts limits mitochondrial calcium accumulation during ischemia♀️♂️🫀 https://www.jmcc-online.com/article/S0022-2828(26)00031-3/fulltext22 Jun 2026 12:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3moutpnnlyl2qhttps://bsky.app/profile/jmccardiology.bsky.social/post/3monce4dzgi2i🆕 in JMCC: Zhou et al. reveal strikingly similar metabolic signatures in human end-stage ischemic and nonischemic cardiomyopathy. Both exhibit altered amino acid metabolism, oxidative stress, purine breakdown, and depleted glutathione ⚡️🫀 https://www.jmcc-online.com/article/S0022-2828(26)00032-5/fulltext19 Jun 2026 12:03 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3monce4dzgi2ihttps://bsky.app/profile/jmccardiology.bsky.social/post/3mokrtn2nx62z🆕 in JMCC: Liu et al. identify hematopoietic PI3Kγ as a key driver of abdominal aortic aneurysm progression. PI3Kγ promotes macrophage trafficking, aortic inflammation, and aneurysm growth, highlighting a potential therapeutic target 🎯 https://www.jmcc-online.com/article/S0022-2828(26)00039-8/fulltext18 Jun 2026 12:02 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mokrtn2nx62zhttps://bsky.app/profile/jmccardiology.bsky.social/post/3moibhpghvt2l🚨 New in JMCC: Jiang et al. identify the CYLD-RIPK1 axis as a key regulator of DNA damage and pathological cardiac hypertrophy. Targeting CYLD attenuated remodeling and preserved cardiac function in pressure-overloaded hearts 🎯 https://www.jmcc-online.com/article/S0022-2828(26)00043-X/fulltext17 Jun 2026 12:04 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3moibhpghvt2lhttps://bsky.app/profile/jmccardiology.bsky.social/post/3mofs7p4t7322🆕 in JMCC: Bacchini et al. show that aging and cardiomyopathy jointly reshape unfolded protein response pathways, highlighting defective proteostasis as a key contributor to myocardial dysfunction and heart failure 👴🏼👵🏼🫀 https://www.jmcc-online.com/article/S0022-2828(26)00040-4/fulltext16 Jun 2026 12:25 +0000at://did:plc:dpnbuivndmf2de4vgbfh6y3d/app.bsky.feed.post/3mofs7p4t7322