Unraveling the secrets of bacterial injection needles .. (among other things)https://bsky.app/profile/basler-lab.bsky.socialhttps://bsky.app/profile/basler-lab.bsky.social/post/3mv3decsnuk2qIn our new paper, we uncover how Burkholderia switches from antibacterial T6SS-1 to eukaryotic-targeting T6SS-5. Surprisingly, actively turning off T6SS-1 assembly prevents mitochondrial damage and apoptosis. Congrats @christy-chc.bsky.social and the team! http://link.springer.com/article/10.1038/s44319-026-00905-209 Sep 2026 10:29 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3mv3decsnuk2qhttps://bsky.app/profile/basler-lab.bsky.social/post/3msultcpwz22jInterested in the Function and Regulation of #T6SS? Do you have relevant experience from your Master's project? Apply to this PhD position in our lab: https://www.biozentrum.unibas.ch/open-positions/detail/phd-student-function-and-regulation-of-type-6-secretion-system12 Aug 2026 07:22 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3msultcpwz22jhttps://bsky.app/profile/basler-lab.bsky.social/post/3mpcb7oh7n22xA Garmin watch face with a living microbial battlefield powered by your daily stats that is never the same! 🦠⌚️ The BacFighT6 Watch Face runs a live, #T6SS mediated bacterial simulation on your wrist. https://apps.garmin.com/apps/eaf881d8-df08-41d3-bc4f-ccb9340e56ce27 Jun 2026 20:08 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3mpcb7oh7n22xhttps://bsky.app/profile/basler-lab.bsky.social/post/3mpcazjnvxk2xTurn your phone into a bacterial battle ground! 🦠📱 The new BacFighT6 #Android app is both a simulation playground AND a Live Wallpaper. Customize cell parameters, tweak visuals, and watch #T6SS battles evolve right on your home screen! Download here: https://github.com/BaslerLab/BacFighT6-Android27 Jun 2026 20:05 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3mpcazjnvxk2xhttps://bsky.app/profile/basler-lab.bsky.social/post/3mpcaw6vuic2xNew version of BacFighT6! sites.google.com/view/bacfight6 Diffusible toxins produced by prey to impact interactions of Attackers, Defenders and Prey! This can make #T6SS battles interestingly unstable. Like this simulation with no winner after 100k steps: https://baslerlab.github.io/BacFighT6/index.html?Simulation_Seed=42&preset=battleroyale 👇27 Jun 2026 20:03 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3mpcaw6vuic2xhttps://bsky.app/profile/basler-lab.bsky.social/post/3m6pwoij4b223Big congrats to @atejadaarranz.bsky.social and co-authors on this paper showing novel insights into the resistance to #T6SS effectors and an unexpected link to antibiotic resistance! Thanks @nccr-antiresist.bsky.social for funding and supporting the collaboration with the Jenal lab! rdcu.be/eShqI https://rdcu.be/eShqI28 Nov 2025 22:29 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3m6pwoij4b223https://bsky.app/profile/basler-lab.bsky.social/post/3m5uc3wkbw225Update to BacFighT6, with presets for easy exploration of complex behaviors: sites.google.com/view/bacfight6 Try "battle royale" preset where prey (blue) produce capsule, attackers (red) move towards prey and feed on it, defenders (orange) retaliate! Took a while to eliminate the reds!17 Nov 2025 22:39 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3m5uc3wkbw225https://bsky.app/profile/basler-lab.bsky.social/post/3m5sy4yilas2mHappy to share our latest T6SS review: https://nature.com/articles/s41579-025-01256-w Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!17 Nov 2025 10:08 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3m5sy4yilas2mhttps://bsky.app/profile/basler-lab.bsky.social/post/3lrnh3h4d2c2oMajor update to BacFighT6: https://sites.google.com/view/bacfight6/ Simulate the role of motility/chemotaxis, capsule production, activation by autoinducers, contact dependent killing, kin-exclusion, foraging and more. Long simulations, extensive data import/export and analysis. Interactive Q&A!15 Jun 2025 12:17 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3lrnh3h4d2c2ohttps://bsky.app/profile/basler-lab.bsky.social/post/3lq3lhrudr22nTo make our research more approachable, I used #Gemini to develop (mostly by #vibecoding) a simulation of #T6SS mediated bacterial interactions. I hope that you'll have as much fun as I have with this and that you'll learn something new! https://sites.google.com/view/bacfight6/26 May 2025 16:22 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3lq3lhrudr22nhttps://bsky.app/profile/basler-lab.bsky.social/post/3lnqblpezrs2zHappy to help William with his high school graduation project: https://inspiration.sjf.ch/the-role-of-uncharacterised-genes-in-the-activity-of-the-acinetobacter-baylyi-type-vi-secretion-system/ https://youtu.be/u0d72T9rRQg?si=koTM0ClrD4H6cXgd Congratulations! Thanks to @biozentrum.unibas.ch and @nccr-antiresist.bsky.social for support!26 Apr 2025 17:36 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3lnqblpezrs2zhttps://bsky.app/profile/basler-lab.bsky.social/post/3ljo2ex5fo22nPoke bacteria with a sharp needle and they poke back in just a few seconds! Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage! Collaboration with Rod Lim's lab @biozentrum.unibas.ch https://www.science.org/doi/10.1126/sciadv.adr171305 Mar 2025 22:41 +0000at://did:plc:drhi7ilbnerinkdc6lefz6ci/app.bsky.feed.post/3ljo2ex5fo22n