@CNRS Research Director @ENS_ULM. Interested in Droplets, Metabolism, Organelles, Lipids, BioPhysics, Microfluidics & Co, 🇸🇳https://bsky.app/profile/abdourachidthiam.bsky.socialhttps://bsky.app/profile/abdourachidthiam.bsky.social/post/3msddpzlqks2rA long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER membrane, which converts small lipid changes into a cooperative transcriptional response. https://www.biorxiv.org/content/10.64898/2026.08.01.740796v105 Aug 2026 10:42 +0000at://did:plc:e3cfgrcbovxuvrsltz4y3k5b/app.bsky.feed.post/3msddpzlqks2rhttps://bsky.app/profile/abdourachidthiam.bsky.social/post/3mngyycgjfs22Happy to share our review of seipin as a lipid rheostat, not just a #lipiddroplet biogenesis factor. Its flexible structure, with cofactors and ligands, integrates metabolic cues at organelle contacts, coordinating lipid storage, membrane synthesis, and signaling. https://rupress.org/jcb/article/225/7/e202602009/282654/04 Jun 2026 06:34 +0000at://did:plc:e3cfgrcbovxuvrsltz4y3k5b/app.bsky.feed.post/3mngyycgjfs22