Our laboratory seeks to understand how chromosome structure relates to genome functionshttps://bsky.app/profile/elphegenoralab.bsky.socialhttps://bsky.app/profile/elphegenoralab.bsky.social/post/3mofnwyna422eInterested in hearing about mechanisms of cohesin-dependent vs. -independent enhancer regulation? @karissalhansen.bsky.social will be presenting her work **Tues June 23rd 8am CET** https://www.biorxiv.org/content/10.64898/2026.05.07.723561v1.full https://www.science.org/doi/10.1126/science.adt4221 Thank you @genome-org-aus.bsky.social ! 👇 [contains quote post or other embedded content]16 Jun 2026 11:09 +0000at://did:plc:fluy3lb5ftmtj4fjd5uhzz7t/app.bsky.feed.post/3mofnwyna422ehttps://bsky.app/profile/elphegenoralab.bsky.social/post/3mlovg2633s26Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇12 May 2026 23:01 +0000at://did:plc:fluy3lb5ftmtj4fjd5uhzz7t/app.bsky.feed.post/3mlovg2633s26https://bsky.app/profile/elphegenoralab.bsky.social/post/3mk6kfojfck2j📖 The final version of our paper is out in press Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption https://authors.elsevier.com/a/1m%7EU03vVUPZO2Z or https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00233-9 [contains quote post or other embedded content]23 Apr 2026 17:36 +0000at://did:plc:fluy3lb5ftmtj4fjd5uhzz7t/app.bsky.feed.post/3mk6kfojfck2j