PrIISM at Icahn Mount Sinai | powering immunology research from human profiling through mechanistic studies in preclinical models, towards the development & testing of new immunotherapieshttps://bsky.app/profile/sinaiimmuno.bsky.socialhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mk6cyy74ss2cWe hosted our first Immunotherapeutics retreat recently, bringing together faculty to spotlight the most promising translational therapies and define where we can accelerate impact. A day focused on turning beautiful science into effective interventions.23 Apr 2026 15:24 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mk6cyy74ss2chttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mhizcfk5ik2yLast chance to SIGN UP FOR FREE and hear the latest on immune aging and immunotherapy to extend healthspan from the following founders in the field, online, all welcome, Mar 23 - 25: https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370920 Mar 2026 17:14 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mhizcfk5ik2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mhbkzqldas2y🪩 NEW 🪩 in @aacrjournals.bsky.social Cancer Discovery by @michelletran9.bsky.social @bhardwajlab.bsky.social inflammation in the blood is linked to tumor macrophages that shut down T cells and limit immunotherapy response > new ways to improve bladder cancer therapy: https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-1774/774912/A-tumor-promoting-inflammatory-SPP1-macrophage-IL17 Mar 2026 18:10 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mhbkzqldas2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mgustbo2lc2yAt Immunoschool, Eicke Latz will discuss targeting inflammasomes, the innate immune sensors linking lifestyle exposures - from Western diet to metabolic stress - to the chronic inflammation that impacts healthspan. Hear more at the online Immunoschool Mar 23 - 25: https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370912 Mar 2026 16:25 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mgustbo2lc2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mgfjcf6oek26Join us at the 🌏 Immunoschool Mar 23 - 25 🌇 EST to hear more from John Sedivy about how retrotransposons—ancient elements in our genome—shape immune aging and activate nucleic-acid sensing pathways and inflamaging, opening up new therapeutic opportunities. ✍️ FREE https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370906 Mar 2026 14:24 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mgfjcf6oek26https://bsky.app/profile/sinaiimmuno.bsky.social/post/3mg5vqnm7es2pLike to prep for class? In @nataging.nature.com Dr Merad lays out a key concept in immune aging: protective tissue-resident macrophages are replaced by inflammatory BM–derived macs, driving tissue decline and cancer risk. Restoring TRMs may be central to healthy aging: https://www.nature.com/articles/s43587-025-00898-y [contains quote post or other embedded content]03 Mar 2026 13:46 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mg5vqnm7es2phttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mg5topuzxc2oResearching immune aging means playing the long game. Lifespan & healthspan science demands longitudinal human studies to uncover what drives resilience vs decline. Hear how from NIA Scientific Director Luigi Ferrucci at Immunoschool. Free registration: https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370903 Mar 2026 13:09 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mg5topuzxc2ohttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mg3lt32e522oAt Immunoschool, @gitlinlabmsk.bsky.social will show how VEXAS syndrome is reshaping our understanding of immune aging, late-onset inflammatory disease & new routes to immunotherapy. A powerful 🔗 between clonal hematopoiesis & systemic inflammation. Register FREE: https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370902 Mar 2026 15:43 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mg3lt32e522ohttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mftxo6whzk2yWhen immune cells go senescent, the whole body may follow. But next generation immunotherapies like CAR-T cells and vaccines targeting senoantigens could help us fight back. Don't be a 🧟‍♀️ and 😴 on this opportunity to hear how we can target senescence: FREE sign-up: https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370927 Feb 2026 14:54 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mftxo6whzk2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mfrpbi2zcc2yIn @cp-cancercell.bsky.social, @brownlab1.bsky.social & @miriammerad.bsky.social review how tumor macrophages shape cancer and their plasticity enables new bioengineering approaches to block tumor-promoting signals or reprogram them into tumor-fighting cells. 🧐 https://www.sciencedirect.com/science/article/pii/S1535610826000590?dgcid=author26 Feb 2026 17:18 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mfrpbi2zcc2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mfrhtkczsk2yStill ⏰ to sign up for 3 days of cutting-edge science on how aging reshapes the immune system and interventions to extend healthspan: Register FREE: https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-1981804533709 Learn about Immunoschool from @miriammerad.bsky.social in this interview https://reports.mountsinai.org/article/grad2025-08-miriam-merad-research26 Feb 2026 15:05 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mfrhtkczsk2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mfp55z2afk2y📝 by @drshrutinaik.bsky.social exemplifies our principle: one immune system, different diseases, shared solutions. Hyper-reactive DCs in infant skin trigger eczema and may drive later asthma and food allergy ⏩ distinct diseases with shared biology & prevention targets. https://www.nature.com/articles/s41586-026-10162-x25 Feb 2026 16:49 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mfp55z2afk2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mfmlafjlfs2yWhat do 🍓🍓🍓 have to do with aging? Check out the Immunoschool program and see if you can figure out the 🍓related topic, inspired by research from @mattyousefzadeh.bsky.social and others on immune-driven tissue decline and new ways to slow, halt or even reverse it. PROGRAM: immunoschool.org24 Feb 2026 16:22 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mfmlafjlfs2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mfmkdq7xy22yPreserving 🧠 function helps lifelong learners like scientists keep discovering, mentoring and sharing decades of insight with those who come next. Tony Wyss-Coray will explore how immune factors shape 🧠 aging and resilience in the Immunoschool. Program: immunoschool.org Register: lnkd.in/e3NGpYHW24 Feb 2026 16:06 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mfmkdq7xy22yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mfk7utjnbs2yWhat if aging begins in the youngest immune cells? Emmanuelle Passegué reveals how changes in hematopoietic stem cells drive declining immunity, inflammaging & disease risk, and how restoring them could rebuild resilience. Program: immunoschool.org Register FREE: https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370923 Feb 2026 17:54 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mfk7utjnbs2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mfcyv57ve22yGuido Kroemer joins the 2026 Immunoschool to highlight the hallmarks of immune aging and how they drive decline. Aging hallmarks—from genomic instability to inflammaging—are interconnected & potentially targetable. See what's on immunoschool.org FREE to register https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370920 Feb 2026 21:00 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mfcyv57ve22yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mfa3dy6q422yThe immune system profoundly shapes aging as it interacts with every organ. New single-cell & spatial tools now map where this relationship breaks down and where interventions support healthy longevity. More @ Immunoschool Program: immunoschool.org Register (free): https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370919 Feb 2026 17:06 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mfa3dy6q422yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mf3nnen67s2yFREE registration is now open for this year’s International Immunoschool on IMMUNE AGING: ✍️ https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-1981804533709 From mechanism to translation, there’s something for every career stage. Explore the program here: 🧐 immunoschool.org First speaker is @miriammerad.bsky.social...17 Feb 2026 22:50 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mf3nnen67s2yhttps://bsky.app/profile/sinaiimmuno.bsky.social/post/3mey7on4pus2y📣 Immunoschool 2026 is open for registration 📣 Explore how immunotherapy can promote healthy longevity, from targeting senescent cells to rejuvenating exhausted immunity and reducing inflammaging. FREE, online March 23–25. Program: immunoschool.org Register: https://www.eventbrite.com/e/international-course-of-immunotherapy-march-23-25-2026-tickets-198180453370916 Feb 2026 14:02 +0000at://did:plc:fpoy7saihmyglqkkdapboy3a/app.bsky.feed.post/3mey7on4pus2y