https://bsky.app/profile/realjoshsiegel.bsky.socialhttps://bsky.app/profile/realjoshsiegel.bsky.social/post/3miy2wvbuuk23How Psychedelics Affect the Brain https://www.nytimes.com/2026/04/07/health/psychedelic-medicine-brain.html?smid=nytcore-ios-share08 Apr 2026 10:18 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3miy2wvbuuk23https://bsky.app/profile/realjoshsiegel.bsky.social/post/3me7bpjaq7s23The big questions facing psychedelic science: 1. What’s the biology of psychedelic experiences? 2. Is the experience necessary for clinical benefit? 3. How do we solve expectancy+unblinding in trials? We synthesize what we know and the big Qs in a Nature Med Review: https://nature.com/articles/s41591-025-04194-506 Feb 2026 16:02 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3me7bpjaq7s23https://bsky.app/profile/realjoshsiegel.bsky.social/post/3me2nayy24c2kThis 👇is the last revolution. We are working on the next one - and need your help. HIRING: Postdoc at NYU (Center for Psychedelic Medicine). Looking for strong neuroimaging, human subjects experience, a publication track record, and top scientistiness. Send CV to joshua.siegel@nyulangone.org [contains quote post or other embedded content]04 Feb 2026 19:45 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3me2nayy24c2khttps://bsky.app/profile/realjoshsiegel.bsky.social/post/3lwtpcbflok2lWhat went wrong with MDMA for PTSD at the FDA? Was the recent Compass trial a success or a letdown? Should practitioners have to "trip" themselves? I sat down with the great and wise Dr. Mark Gold to explore the controversy and bleeding edges of psychedelic science: https://youtube.com/watch?v=oitUhjlq8m420 Aug 2025 15:06 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3lwtpcbflok2lhttps://bsky.app/profile/realjoshsiegel.bsky.social/post/3lrjc6tzh2s2hAnyone going to Psychedelic Science 2025 in Denver? I'm on a panel - "Beyond the Blobs: Visualizing the Psychedelic Brain" - with a film maker (Ethan Goldwater) and he made an incredible video JUST for the panel. https://drive.google.com/file/d/1317DeNQBI69po-Jd8QegaJzWPkHqq5Ym/view13 Jun 2025 20:39 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3lrjc6tzh2s2hhttps://bsky.app/profile/realjoshsiegel.bsky.social/post/3lqut6mc6ok23This extraordinary psychedelic dataset is now fully/freely available to all! All the info to access & use it in a newly published Nature Scientific Data Resource: rdcu.be/epxe7 Thanks to the incredible team who created it - Subha S, Rick R, Ginger N, to name a few. Translate that into Japanese! [contains quote post or other embedded content]05 Jun 2025 17:17 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3lqut6mc6ok23https://bsky.app/profile/realjoshsiegel.bsky.social/post/3lqihzgxqa22t"Effects of Psilocybin on Clergy..." The resutls are just ... incredible. "participants rated their psilocybin experiences to be among the top five most spiritually significant (96%) of their lives..." https://liebertpub.com/doi/10.1089/psymed.2023.004431 May 2025 19:25 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3lqihzgxqa22thttps://bsky.app/profile/realjoshsiegel.bsky.social/post/3lptuzzgngc2dThe brain signature of a single dose of Ritalin in six participants in our precision functional mapping study was highly significant and well matched to stimulant effects determined in thousands of subjects in the ABCD data set. PFM provides powerful drug bio markers! Stay tuned for more on this [contains quote post or other embedded content]23 May 2025 14:52 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3lptuzzgngc2dhttps://bsky.app/profile/realjoshsiegel.bsky.social/post/3loopwrl3nk25Major praise to the @nyulangone.bsky.social podcast team. I expected just a little internal thing, but they did an AMAZING job digging into the science and creating a great show. Check it out - YouTube (full-length): https://youtu.be/h8Thc-BDvZ0Apple Spotify: https://open.spotify.com/episode/3WHKV3NLa5AUPizrtTzxCB?si=b036e38b51e14b0a08 May 2025 20:12 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3loopwrl3nk25https://bsky.app/profile/realjoshsiegel.bsky.social/post/3lmumfu3i322eIt's terrifying to watch a tyrannical power grab in America. But also ... kind of fascinating... in a twisted way. Really brings the history books to life, huh? https://www.economist.com/leaders/2025/02/20/donald-trump-the-would-be-king15 Apr 2025 17:35 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3lmumfu3i322ehttps://bsky.app/profile/realjoshsiegel.bsky.social/post/3lmhuzzdmik24This is *crucial* to the future translational potential of resting fMRI [contains quote post or other embedded content]10 Apr 2025 16:05 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3lmhuzzdmik24https://bsky.app/profile/realjoshsiegel.bsky.social/post/3lkqmsple622aJust heard a fascinating talk by Mir Jalil Razavi! 🤯 Cortical folding is driven by surface expansion. Tiny differences in cortical thickness and starting morphology drive patterning of the brain surface. Crucial info to anyone who wants to localize brain function! https://nature.com/articles/srep1447719 Mar 2025 16:41 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3lkqmsple622ahttps://bsky.app/profile/realjoshsiegel.bsky.social/post/3lkltj54fxs2yVote for our Psilocybin study! https://statnews.com/feature/stat-madness/bracket-voting-now-open/ Don't ask me why someone would make a March Madness for academic research. But they did. For the love of science, I guess.17 Mar 2025 18:58 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3lkltj54fxs2yhttps://bsky.app/profile/realjoshsiegel.bsky.social/post/3ldr2nd7xus2aIf you are doing fMRI research, you need to start using NORDIC thermal denoising. It is a game changer. @drdamienfair.bsky.social @drjuliamoser.bsky.social Congrats on the paper officially coming out. https://direct.mit.edu/imag/article/doi/10.1162/imag_a_00426/12563720 Dec 2024 18:52 +0000at://did:plc:fs2rdhtl25cmficft4uefbvv/app.bsky.feed.post/3ldr2nd7xus2a