Geneticist, Skeletal Muscle, Drug development, Gene therapies. Non-coding RNA, and Zebrafish Aficionado. Lover of all things muscle. All posts are my own. Instagram @thealexanderlab Lab website: https://www.uab.edu/medicine/peds/research/division-researchttps://bsky.app/profile/mattmuscleguy.bsky.socialhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mu3iubchms2cNew #Dev_Cell paper from @RelaixLab #Morikis #LeGrandLab1 and colleagues: Postnatal Pax7-expressing limb cells are multipotent and generate non-myogenic lineages that persist into adulthood. #Myoblue tinyurl.com/4btwerez https://tinyurl.com/4btwerez27 Aug 2026 18:42 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mu3iubchms2chttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mtysdgubbs2jInteresting new #NatureAging paper: Contractile myografts confer systemic anti-aging benefits. #Myoblue tinyurl.com/49unvd2s https://tinyurl.com/49unvd2s26 Aug 2026 16:54 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mtysdgubbs2jhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mtwekk3hbs2uNew #jclinicalinvest paper: Immune Cell–Specific SMN Expression and Sustained Immune Alterations in Treated Spinal Muscular Atrophy. #SMA #Myoblue tinyurl.com/3kdmc7wj https://tinyurl.com/3kdmc7wj25 Aug 2026 17:42 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mtwekk3hbs2uhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mtjuiv6zo22rNew #stemcellreports paper from Brad Olwin's group: TDP-43 sustains satellite cells to maintain and regenerate skeletal muscle. #Myoblue tinyurl.com/4msphru6 https://tinyurl.com/4msphru620 Aug 2026 18:23 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mtjuiv6zo22rhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3msgrb5blvc2rNew #MolTherNucAcids paper: Givinostat enhances antisense oligonucleotide efficacy in the mdx52 model of Duchenne muscular dystrophy. #DMD tinyurl.com/y9a6shwu https://tinyurl.com/y9a6shwu06 Aug 2026 19:22 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3msgrb5blvc2rhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3msdqstawd227New #SkeletalMuscle paper: Human iPSC-based skeletal muscle model of LAMA2-related congenital muscular dystrophy. tinyurl.com/mvzve72j https://tinyurl.com/mvzve72j05 Aug 2026 14:36 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3msdqstawd227https://bsky.app/profile/mattmuscleguy.bsky.social/post/3msdq55lprk27New #SkeletalMuscle paper: An integrative multi-omic analysis of skeletal muscle in response to disuse and recovery resistance training in resistance trained and untrained young adults. tinyurl.com/3pupd9n9 https://tinyurl.com/3pupd9n905 Aug 2026 14:24 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3msdq55lprk27https://bsky.app/profile/mattmuscleguy.bsky.social/post/3mqjvdgyblc2fInteresting new #SkeletalMuscle paper: Evaluation of a serum protein signature as monitoring biomarker for Duchenne muscular dystrophy in a long-term clinical trial with corticosteroids. #DMD tinyurl.com/58m6aprh https://tinyurl.com/58m6aprh13 Jul 2026 14:22 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mqjvdgyblc2fhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mptjvgx4oc2bNew #CommsBio paper: Myofiber-specific knockout of TGF-β type I receptors in mice concurrently drives muscle hypertrophy, oxidative metabolism, and absolute force. #Myoblue tinyurl.com/42b9p8yr https://tinyurl.com/42b9p8yr04 Jul 2026 16:59 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mptjvgx4oc2bhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mpogbf7lbs2xNew #CardiologyandTherapy paper: Cardiac Safety Outcomes in Delandistrogene Moxeparvovec Clinical Trials for Duchenne Muscular Dystrophy with Up to 5 Years of Follow-up. #DMD #Myoblue tinyurl.com/2k59duv6 https://tinyurl.com/2k59duv602 Jul 2026 16:11 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mpogbf7lbs2xhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mpo2itjne22bCongrats to #Rudnicki_Lab & colleagues for their new #SkeletalMuscle paper: Regenerative Index: a method to assess muscle regeneration in patients with Duchenne muscular dystrophy. #Myoblue tinyurl.com/yjjswwe8 https://tinyurl.com/yjjswwe802 Jul 2026 12:40 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mpo2itjne22bhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mp53jhkqgc2cNew #stemcellreports paper: Resident mesenchymal progenitor cells require autocrine IGF-I in homeostatic and regenerating skeletal muscle. #Myoblue tinyurl.com/3b9k89pe https://tinyurl.com/3b9k89pe25 Jun 2026 18:43 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mp53jhkqgc2chttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mp2vtgzlx22iNew #ScienceTM paper: Kbtbd13 knockdown restores muscle function in a clinically relevant mouse model of nemaline myopathy type 6. #Myoblue tinyurl.com/mmp34wsw https://tinyurl.com/mmp34wsw24 Jun 2026 21:56 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mp2vtgzlx22ihttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3moq4xhmlvs2nNew #SkeletalMuscle paper: Targeting muscle fibrosis using non-specific collagenase injections destabilizes the basal lamina and induces matrix remodeling. #Myoblue tinyurl.com/yk4fhxda https://tinyurl.com/yk4fhxda20 Jun 2026 15:04 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3moq4xhmlvs2nhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3moga62uflk2sNew #PNAS paper: Restoring the interplay between the endoplasmic reticulum and mitochondria by gene therapy improves Charcot–Marie–Tooth type 2A disease. #Myoblue tinyurl.com/743nhb8k https://tinyurl.com/743nhb8k16 Jun 2026 16:35 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3moga62uflk2shttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3moga2fr6hc2sNew #PNAS paper: Elevated MyoD1 levels expand genome-wide binding and the repertoire of regulated genes. #Myoblue tinyurl.com/bdzxm8zv https://tinyurl.com/bdzxm8zv16 Jun 2026 16:33 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3moga2fr6hc2shttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mog7vmxsik2sCongrats #ToshifumiYokota & colleagues for their new #PNAS paper: DMD-Null mice exhibit severe muscle weakness, impaired regeneration, and deficient satellite cell function. #Myoblue tinyurl.com/hhhwpw3k https://tinyurl.com/hhhwpw3k16 Jun 2026 16:30 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mog7vmxsik2shttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mnzao47akk2zNew #Cell paper: Long-term reversal of Duchenne muscular dystrophy via circular arRNA-guided exon skipping in monkeys and humans. #Myoblue tinyurl.com/nvb5zftp https://tinyurl.com/nvb5zftp11 Jun 2026 12:39 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mnzao47akk2zhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mnhzimz25c2gNew #MolTherapyAdv paper: Preclinical efficacy of a gene therapy for CHKB-mediated muscular dystrophy. #Myoblue tinyurl.com/3vjanc7f https://tinyurl.com/3vjanc7f04 Jun 2026 16:16 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mnhzimz25c2ghttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mnhra5akn22hNew #MuscleAndNerve paper: Five-Year Outcomes With Delandistrogene Moxeparvovecin Patients With Duchenne Muscular Dystrophy: A Phase1/2a Study. #DMD #Myoblue tinyurl.com/mth3a5ps https://tinyurl.com/mth3a5ps04 Jun 2026 13:48 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mnhra5akn22hhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mndbryige22aNew #PNASNews paper from Blau & colleagues: 15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist–induced weight loss. #Myoblue tinyurl.com/ntmcm8kn https://tinyurl.com/ntmcm8kn02 Jun 2026 19:01 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mndbryige22ahttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mmtgsvf4x22rNew #NatureComms paper: Muscle mitochondria, function, mass, and quality of life in prostate cancer during androgen deprivation therapy. #Myoblue tinyurl.com/mupb2yrf https://tinyurl.com/mupb2yrf27 May 2026 11:48 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mmtgsvf4x22rhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mmr7h47mtc2mNew #jclinicalinvest paper: Deficiency of muscular dystrophy-related gene JAG2 causes NOTCH signaling dysfunction in muscle stem cells. #Myoblue tinyurl.com/2s45t3f2 https://tinyurl.com/2s45t3f226 May 2026 14:31 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mmr7h47mtc2mhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mmgsxsi7zs2dNew #SkeletalMuscle paper: Insights into the heterogeneous muscle lipidome of dysferlin-deficient mice: effects of age, muscle type, and sex. #Myoblue tinyurl.com/2cmrsyu3 https://tinyurl.com/2cmrsyu322 May 2026 11:21 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mmgsxsi7zs2dhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mmesy4sh5s2vCongrats to #EricTWang & colleagues on their new #MolTherapy paper: Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy. #Myoblue tinyurl.com/mt75rmaw https://tinyurl.com/mt75rmaw21 May 2026 16:16 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mmesy4sh5s2vhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mmcff3bmd22rInteresting new #Nature paper: Spinal neuromotor rehabilitation using a portable isokinetic training robot. #SMA #Myoblue tinyurl.com/msb84kwn https://tinyurl.com/msb84kwn20 May 2026 17:07 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mmcff3bmd22rhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mlvc5deyt22xNew #NatureAging paper: Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis. #Myoblue tinyurl.com/3uykus38 https://tinyurl.com/3uykus3815 May 2026 12:05 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mlvc5deyt22xhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mltozvoums2lNew #MolTherAdv paper: Extracellular vesicles as biomarkers of disease progression and therapeutic response in patients with spinal muscular atrophy. #Myoblue tinyurl.com/2b4m6jfx https://tinyurl.com/2b4m6jfx14 May 2026 20:50 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mltozvoums2lhttps://bsky.app/profile/mattmuscleguy.bsky.social/post/3mlto4ql6uc2lNew #stemcellreports paper: Developmental dynamics of skeletal muscle can be recapitulated in vitro from pig embryonic stem cells. #Myoblue tinyurl.com/3sbwd2mn https://tinyurl.com/3sbwd2mn14 May 2026 20:34 +0000at://did:plc:gdzgei7kta5vyvbhogx7adn4/app.bsky.feed.post/3mlto4ql6uc2l