My rubbish research: Tumorigenesis is a process of progressive loss of original cell identity and acquirement of neural stemness, the general stemness that determines both tumorigenicity and pluripotency. EMT/MET/EndMT are groundless 'concepts'https://bsky.app/profile/neuralgrndstate.bsky.socialhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mvf3nvv33s23Understanding cancer cell/complexity/therapy/CANCER PAIN &even the inverse correlation between cancer and Alzheimer's &... as a whole by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. https://frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1843646/full [contains quote post or other embedded content]13 Sep 2026 07:38 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mvf3nvv33s23https://bsky.app/profile/neuralgrndstate.bsky.social/post/3mvf3m6b7zc23Understand cancer related pain in a simpler, more direct, intuitive way Core property of cancer cells is neural stemness, they can differentiate&make connections with host nerve. https://onlinelibrary.wiley.com/doi/10.1002/ctm2.7081713 Sep 2026 07:37 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mvf3m6b7zc23https://bsky.app/profile/neuralgrndstate.bsky.social/post/3mvekhaails2xUnderstanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates @natrevcancer.nature.com https://frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1843646/full [contains quote post or other embedded content]13 Sep 2026 02:30 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mvekhaails2xhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mvekegy5bk2x'Making sense of cancer: a neurobiological perspective'🫡 https://www.nature.com/articles/s41568-026-00975-3 @natrevcancer.nature.com13 Sep 2026 02:29 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mvekegy5bk2xhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mureugqdcc2j@ruxandrabio.bsky.social @nytopinion.nytimes.com How was this beautiful conclusion reached? 'science is no longer the main bottleneck to new drugs' How much cancer cells and cancer have been properly understood? [contains quote post or other embedded content]05 Sep 2026 11:30 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mureugqdcc2jhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mulfwgxzvk2nEMT is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps many are awaiting), &keep instilling 'EMT knowledge' to young researchers. Sigh. @natgenet.nature.com https://www.nature.com/articles/s41588-026-02723-703 Sep 2026 02:33 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mulfwgxzvk2nhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mu7ta7hh2k2fVery very tiny/preliminary research with the last few bucks, but might be somewhat inspiring-[Preprint] ‘Expression of immune checkpoint VISTA represents a differentiated state of cancer cells and plays a role in regulating actin cytoskeleton’ https://biorxiv.org/content/10.64898/2026.08.24.746888v1 [contains quote post or other embedded content]29 Aug 2026 11:59 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mu7ta7hh2k2fhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mu7t6menlc2fQuestions🤔🤨 A gene with high expression in tumor cells&correlating with progression/poor prognosis seems to be a good candidate of target, right? Better to target malignant or nonmalignant, high or weak malignant cells in tumors? Immune checkpoints also play other roles than immunity?29 Aug 2026 11:58 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mu7t6menlc2fhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mu5fbgwff22fAnybody can tell what the hell is the so-called epithelial–mesenchymal-transition stuff&what it can help? @natgenet.nature.com 'These include a poorly differentiated lineage driven by epithelial–mesenchymal-transition-related MRs...' https://www.nature.com/articles/s41588-026-02714-828 Aug 2026 12:44 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mu5fbgwff22fhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mtja6kgtsc2lThe EMT community still cannot face EMT's essential flaws directly They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the undefinable EMT&related stuffs https://link.springer.com/article/10.1186/s13578-024-01282-w [contains quote post or other embedded content]20 Aug 2026 12:19 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mtja6kgtsc2lhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mtja5e6su22lEpithelial-mesenchymal transition is absolutely a magical stuff. Nobody knows what it is. but people said it explains cancer&other things, &can be exploited to develop cancer therapies (perhaps many are awaiting that), &keep instilling 'EMT knowledge' in young researchers. Sigh. [contains quote post or other embedded content]20 Aug 2026 12:19 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mtja5e6su22lhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mtj7migg2k2lThere's been great adrenaline-pumping breakthrough news these days about AI treating or even curing cancer. But I wonder if AI could help with a specific question that is much simpler than curing cancer. What the hell is so-called EMT? https://nature.com/articles/s41392-026-02881-4 https://sciencedirect.com/science/article/pii/S266700542600109220 Aug 2026 12:09 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mtj7migg2k2lhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mt67tvwxus2fYou don't know what are the epithelial/mesenchymal states, specific E/M markers... &You have forgotten cancer cells are the first cells proven to be pluripotent But you know EMT/EMP&they can explain cancer cell plasticity&everything of cancer @cp-trendscancer.bsky.social [contains quote post or other embedded content]16 Aug 2026 03:14 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mt67tvwxus2fhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mt67gmavms2fUnderstanding 'Neuron–tumor communication in solid tumors' through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1843646/full @cp-trendscancer.bsky.social [contains quote post or other embedded content]16 Aug 2026 03:07 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mt67gmavms2fhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mt677y2rh22f"Neural ckeckpoint" @cp-trendscancer.bsky.social Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1843646/full Cancer cells are characteristic of neural cells [contains quote post or other embedded content]16 Aug 2026 03:03 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mt677y2rh22fhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3msx6h2i4gc2nResistance is an integral part of cancer cell property: neural stemness, and its reg. net. Without effective suppression of neural stemness, resistance is always there. There are ways to reprogram the whole reg. net, instead of single or combi. of single molecules, cancer cell: via differentiation [contains quote post or other embedded content]13 Aug 2026 08:00 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msx6h2i4gc2nhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3msx66usiek2nAs generalized before, most cancer promoting genes are enriched in embryonic neural/neural stem cells, incl. KRAS/AKT/MYC/ERK... They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells. https://frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1843646/full [contains quote post or other embedded content]13 Aug 2026 07:56 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msx66usiek2nhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3msx64d64o22nBeautiful mechanisms and illustrations. Similar mechanisms have appeared numerous times: resistance results from activation/upregulation of other oncofactors, MYC, AKT, ERK... What does this mean? https://www.nature.com/articles/s41591-026-04537-w13 Aug 2026 07:54 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msx64d64o22nhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3msrsz3h5k22t@bloodjournals.hematology.org [contains quote post or other embedded content]11 Aug 2026 04:52 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msrsz3h5k22thttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3msrsgk5apk2tPure data analysis generates revolutionary conclusion🤔🫡. https://pnas.org/doi/10.1073/pnas.2528110123 https://ashpublications.org/blood/article/140/24/2611/486649/Tracing-the-evolutionary-history-of-blood-cells-to @pnas.org @bloodjournal.bsky.social11 Aug 2026 04:42 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msrsgk5apk2thttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3msrom6fjxk26The evolutionary&developmental origin of 'plasticity'👇 @cp-cellstemcell.bsky.social 'Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates' https://frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1843646/full [contains quote post or other embedded content]11 Aug 2026 03:34 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msrom6fjxk26https://bsky.app/profile/neuralgrndstate.bsky.social/post/3msroia2kxk26The price of plasticity: Losing colon identity to gain metastatic potential https://www.cell.com/cell-stem-cell/abstract/S1934-5909(26)00265-1 @cp-cellstemcell.bsky.social11 Aug 2026 03:31 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msroia2kxk26https://bsky.app/profile/neuralgrndstate.bsky.social/post/3msrobcdg2226The EMT community still cannot face EMT's essential flaws directly They remain a stance of ignoring&silent about related controversies (though not without verbal attacks in private), &keep repeating the mythic tales about the misbegotten EMT&related stuffs [contains quote post or other embedded content]11 Aug 2026 03:27 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msrobcdg2226https://bsky.app/profile/neuralgrndstate.bsky.social/post/3msro4wedxk26Those who believe that EMT is helpful for understanding cancer and other things should first figure out what the hell is the so-called EMT&how it can be helpful 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' https://link.springer.com/article/10.1186/s13578-024-01282-w [contains quote post or other embedded content]11 Aug 2026 03:25 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msro4wedxk26https://bsky.app/profile/neuralgrndstate.bsky.social/post/3msrnw6nq6c26EMT is absolutely a magical stuff Nobody knows what it is but people say it explains cancer&other things, &can be exploited to develop cancer therapy (perhaps many are awaiting that) &keep instilling 'EMT knowledge' to young researchers Sigh https://www.nature.com/articles/s41467-026-75521-8 @natcomms.nature.com11 Aug 2026 03:21 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msrnw6nq6c26https://bsky.app/profile/neuralgrndstate.bsky.social/post/3msfqold4ak2oIf this still isn't the true face of cancer, then maybe another 6M papers need to be published to uncover it, or we'll just have to turn to artificial intelligence. [contains quote post or other embedded content]06 Aug 2026 09:39 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msfqold4ak2ohttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3msfqbn2egc2oAfter trillions$ spent on cancer research and ~6M cancer papers published, how much is known about cancer cells&cancer? A latest review summarizing how cancer cells&cancer look like👇 https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1843646/full06 Aug 2026 09:31 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3msfqbn2egc2ohttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3ms6hzwvg3k2uPlus, you don't know what the hell is EMT, but you know clearly EMT is responsible for resistance. LOL. 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' https://link.springer.com/article/10.1186/s13578-024-01282-w [contains quote post or other embedded content]03 Aug 2026 12:15 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3ms6hzwvg3k2uhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3ms6hwusirk2uLike that cancer cells are not solely a problem of single molecules, resistance is not, either The core property of cancer cell is neural stemness. Without fully inhibition of neural stemness of cancer cells, resistance is always there https://www.nature.com/articles/s41392-026-02924-w03 Aug 2026 12:14 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3ms6hwusirk2uhttps://bsky.app/profile/neuralgrndstate.bsky.social/post/3mrwuvodpb22fNO ONE HAS EVER MENTIONED THAT CANCER CELLS THEMSELVES ARE CHARACTERISTIC OF NEURAL CELLS. Or maybe this doesn't deserve to be mentioned at all 1. Cancer (tumorigenic) cells≈Neural stem/progenitor cells 2. Tumors ≈ Conjoined twin-like structures (formed during postnatal stage) [contains quote post or other embedded content]31 Jul 2026 11:44 +0000at://did:plc:gjtrvs25pgss4obzhssj2s7s/app.bsky.feed.post/3mrwuvodpb22f