Biomedical Data Science Center Director @CHUV. Professor at @UNIL and @EPFL. AI, ML, and statistical learning for high-dimensional (single-cell/spatial) data in clinical and translational medicine. Interdisciplinary scientist passionate about data.https://bsky.app/profile/rgottardo.bsky.socialhttps://bsky.app/profile/rgottardo.bsky.social/post/3mf5gxv7pi22nNew preprint 🧫🧬 Spatial transcriptomics (~550,000 cells, 2,432 patient-derived organoids): we map gene expression, shape, and function in space to understand cancer biology and drug response. w/ @marianna-raps.bsky.social @khomicsko.bsky.social and Maxim Norkin https://www.biorxiv.org/content/10.64898/2026.02.10.704651v218 Feb 2026 15:56 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3mf5gxv7pi22nhttps://bsky.app/profile/rgottardo.bsky.social/post/3mdpdjipfek24Huge congrats to Teofila, Jeremy & Antoine on the 2026 Pfizer Research Prize 👏 #PrecisionDermatolology driven by translational #DataScience at #CHUV & @unil.bsky.social. More to come with #AI & #SpatialBiology. Hats off to Michel Gilliet for this vision. 🔗 https://www.pfizerresearchprize.ch/awardees-2026/research-projects/a-molecular-map-enables-personalized-skin-treatment31 Jan 2026 07:52 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3mdpdjipfek24https://bsky.app/profile/rgottardo.bsky.social/post/3lsvtolzx6c2p🧬 New paper out! 🔗 https://www.nature.com/articles/s41467-025-61023-6 Frustrated by noisy CITE-seq data? ADTNorm helps normalize it and introduces a staining index to assess antibody quality. Great work by former postdoc Ye Zheng. Supported by @hipcproject.bsky.social #CITEseq #SingleCell #ADTNorm01 Jul 2025 13:49 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lsvtolzx6c2phttps://bsky.app/profile/rgottardo.bsky.social/post/3lstgvxrozk2pBig shoutout to our own Jieran Sun onesinglecell.bsky.social for leading this team effort! 🧠📍 Benchmarking clustering in spatial transcriptomics isn’t easy — but here is SACCELERATOR Preprint: https://www.biorxiv.org/content/10.1101/2025.06.23.660861v1 With markrobinsonca.bsky.social, Naveed Ishaque, Ahmed Mahfouz, Brian Long30 Jun 2025 14:55 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lstgvxrozk2phttps://bsky.app/profile/rgottardo.bsky.social/post/3lsbkq6cuck2sAre you interested in #Xenium panel comparisons: 5K vs targeted? Want to increase cell-type resolution with Xenium? Read our paper and check out our SPLIT method. https://www.biorxiv.org/content/10.1101/2025.04.23.649965v1 Collaboration with @khomicsko.bsky.social cc: @10xgenomics.bsky.social #SpatialTranscriptomics23 Jun 2025 12:15 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lsbkq6cuck2shttps://bsky.app/profile/rgottardo.bsky.social/post/3ls6jdnthhk24🚀 First MOSAIC consortium paper and MOSAIC Window: a rich 60-patient public (multimodal) dataset accessible via EGA. 📄 https://www.biorxiv.org/content/10.1101/2025.05.15.654189v1 #CancerResearch #SpatialTranscriptomics #SingleCell #PrecisionOncology #AI cc: @owkin.bsky.social @10xgenomics.bsky.social22 Jun 2025 07:12 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3ls6jdnthhk24https://bsky.app/profile/rgottardo.bsky.social/post/3ls6gg2h24k2k🎉 New paper alert. We benchmarked Visium, GeoMx, and Chromium for FFPE tumor analysis. Thanks @estellayixingdong.bsky.social for pushing this forward, & MOSAIC collaborators! 📄 https://www.nature.com/articles/s41467-025-59005-9 #SpatialTranscriptomics #CancerResearch cc: @owkin.bsky.social @10xgenomics.bsky.social22 Jun 2025 06:20 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3ls6gg2h24k2khttps://bsky.app/profile/rgottardo.bsky.social/post/3ls6fwmk3dc2kNew expanded @hipcproject.bsky.social starter pack: go.bsky.app/AozZWPx [contains quote post or other embedded content]22 Jun 2025 06:12 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3ls6fwmk3dc2khttps://bsky.app/profile/rgottardo.bsky.social/post/3llh6cyq4cs2yCongratulations @rrmsky.bsky.social ! [contains quote post or other embedded content]28 Mar 2025 15:53 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3llh6cyq4cs2yhttps://bsky.app/profile/rgottardo.bsky.social/post/3lfrevjmubk2w#NIH HIPC consortium starter pack with added members @slimfourati.bsky.social @bjoernpeters.bsky.social @joanndarce.bsky.social @immunespace.bsky.social go.bsky.app/AozZWPx [contains quote post or other embedded content]15 Jan 2025 08:46 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lfrevjmubk2whttps://bsky.app/profile/rgottardo.bsky.social/post/3lduuy7obvs2fPrecision Dermatology 2.0: #DataScience + #Immunology + #Genomics + #Clinical Science. Interdisciplinary collaboration at its best at the @CHUV. https://www.chuv.ch/fr/chuv-home/espace-pro/journalistes/communiques-de-presse/detail/eczema-psoriasis-lupus-et-autres-maladies-inflammatoires-de-la-peau-des-signatures-genomiques-pour-ameliorer-le-diagnostic-et-le-traitement Paper on @naturecomms.bsky.social https://www.nature.com/articles/s41467-024-54559-622 Dec 2024 07:22 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lduuy7obvs2fhttps://bsky.app/profile/rgottardo.bsky.social/post/3lduuq3dprs2fAn older article on why I remain cautiously optimistic about generative #AI in #healthcare: https://www.rts.ch/info/sciences-tech/14069517-lia-generative-dans-le-secteur-de-la-sante-une-revolution-imminente.html22 Dec 2024 07:17 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lduuq3dprs2fhttps://bsky.app/profile/rgottardo.bsky.social/post/3lclhi6sd3s2uThanks #Spotify for letting me know that #Vulfpeck was my #1 artist for 2024. Top 0.05% of listeners worldwide. Almost significant! Of course, not surprised.05 Dec 2024 20:01 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lclhi6sd3s2uhttps://bsky.app/profile/rgottardo.bsky.social/post/3lcl4227xmc2fBy popular demand, I have updated our starter pack in Stats, ML & Omics. Let me know if you'd like to be added. #ML #AI #singlecell #spatial #omics #statistics go.bsky.app/73rcuJn [contains quote post or other embedded content]05 Dec 2024 16:36 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lcl4227xmc2fhttps://bsky.app/profile/rgottardo.bsky.social/post/3lcl3vfvtn22fGreat news! Thrilled about this new appointment at EPFL to strengthen collaborations in biomedical data science across CHUV, @unil.bsky.social, and the EPFL. Excited to work closely with EPFL colleagues and students ! #datascience #AI #medicine #biology https://actu.epfl.ch/news/two-appointments-at-the-school-of-life-sciences/05 Dec 2024 16:33 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lcl3vfvtn22fhttps://bsky.app/profile/rgottardo.bsky.social/post/3lck7uxc5v22fInteresting work from @deep-mind.bsky.social on probabilistic weather forecasting (aka GenCast) https://www.nature.com/articles/s41586-024-08252-9 BUT why didn't they cite previous work in this space by Raftery and colleagues: https://www.science.org/doi/full/10.1126/science.1115255 https://journals.ametsoc.org/view/journals/mwre/133/5/mwr2906.1.xml?tab_body=abstract-display and many other papers!05 Dec 2024 08:12 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lck7uxc5v22fhttps://bsky.app/profile/rgottardo.bsky.social/post/3lbyhagddh22fHere is a starter pack for the #NIH Human #Immunology Project Consortium (@hipcproject.bsky.social). #HIPC members, please reach out if you'd like to be added. go.bsky.app/AozZWPx [contains quote post or other embedded content]28 Nov 2024 06:36 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lbyhagddh22fhttps://bsky.app/profile/rgottardo.bsky.social/post/3lbxg3pzdpk2hOk, as requested, here’s an updated list with additional people: go.bsky.app/73rcuJn Reach out if you want to be added! #AI #ML #DataScience #Omics #SingleCell #SpatialBiology [contains quote post or other embedded content]27 Nov 2024 20:43 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lbxg3pzdpk2hhttps://bsky.app/profile/rgottardo.bsky.social/post/3lbtskea4jk2z@lpachter.bsky.social Interesting! Also, Louvain/Leiden determine the number of clusters automatically (through the resolution), often leading users to assume the default is optimal! However, identifying the correct number of clusters is a complex statistical problem, which shouldn't be ignored. [contains quote post or other embedded content]26 Nov 2024 10:15 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lbtskea4jk2zhttps://bsky.app/profile/rgottardo.bsky.social/post/3lbr7sjg4xk2eThanks @tsanglab.bsky.social for putting this together! #immunology #datascience go.bsky.app/PjH2Fuj [contains quote post or other embedded content]25 Nov 2024 09:34 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lbr7sjg4xk2ehttps://bsky.app/profile/rgottardo.bsky.social/post/3lbpc3kzmmk2tOk, I’ve added a few more people to the list: go.bsky.app/73rcuJn Please reach out if you want to be added! The more the better. #AI #ML #DataScience #Omics #SingleCell #SpatialBiology [contains quote post or other embedded content]24 Nov 2024 15:10 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lbpc3kzmmk2thttps://bsky.app/profile/rgottardo.bsky.social/post/3lbojjg26mk2tOk, I tried to create my own list of people working on developing statistical or machine learning models applied to omics data. I am sure I missed a lot of cool people. If you'd like to be added, let me know. #Stats #ML #Omics go.bsky.app/73rcuJn [contains quote post or other embedded content]24 Nov 2024 07:50 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lbojjg26mk2thttps://bsky.app/profile/rgottardo.bsky.social/post/3lbm5ebnw4s2hWe’re about to get started! [contains quote post or other embedded content]23 Nov 2024 09:07 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lbm5ebnw4s2hhttps://bsky.app/profile/rgottardo.bsky.social/post/3lber6odgab2yJacques Fellay (EPFL) and I (UNIL/CHUV) will be discussing applications of #AI in #Health at 10:30 AM. This is one of the areas where #AI is poised to make the biggest impact in the coming decade. Join us, ask your questions, and be part of the conversation. Don’t miss it—be there or be square! 💡🌍 [contains quote post or other embedded content]20 Nov 2024 10:41 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lber6odgab2yhttps://bsky.app/profile/rgottardo.bsky.social/post/3lbf4cdb24s2hThank you for this incredible honor! 🙏 A huge shoutout to the trainees in my lab—this achievement is thanks to you. Excited for what’s ahead from our Biomedical #DataScience Center at UNIL/CHUV 🚀 #Teamwork #Innovation #AI #HighlyCited2024 https://clarivate.com/highly-cited-researchers/ @unil.bsky.social https://clarivate.com/highly-cited-researchers/?campaignname=Highly_Cited_Researchers_Retention_RA_Global_2024&campaignid=701QO00000IvsB2YAJ&utm_campaign=701QO00000IvsB2YAJ&utm_source=Press_Release&utm_medium=Owned_Press&utm_content=&utm_term=20 Nov 2024 13:59 +0000at://did:plc:h457fpl36crp2ojzy5dx2t4e/app.bsky.feed.post/3lbf4cdb24s2h