@jotbody.bsky.social - Jotbody-Beyond Affinity-

06 Nov 2025 07:47 +0000

💪 Small in size, strong in performance Anti-PD-L1 VHH Antibody (JOT0002-5) by Jotbody: precise PD-L1 detection (ELISA/WB/IHC/IF/FC), 14.4 kDa, KD=0.363 nM. Ideal for research & diagnostics. #PDL1 #VHH #nanobody #lifescience #biotech #researchtools

21 Aug 2025 03:00 +0000

When nanobodies are immobilized directionally via SpyTag/SpyCatcher (90% coupling efficiency), binding capacity triples—and achieves >95% purity from serum with outstanding reuse. https://jotbody.com/could-proper-nanobody-orientation-unlock-peak-performance-in-affinity-chromatography/

19 Aug 2025 02:41 +0000

Plasma EV tau isoform ratios (3R/4R) and TDP-43 levels can distinguish FTD, ALS & PSP with over 90% accuracy—a promising step toward a non-invasive liquid biopsy. #EVs #Neurodegeneration 🔗 Read more about their research: https://jotbody.com/what-if-extracellular-vesicles-in-your-blood-could-reveal-whether-youre-facing-tau-based-dementia-or-tdp-43-related-neurodegeneration/

12 Aug 2025 09:30 +0000

🔍 Can nanobodies transform industrial protein purification? NbHB1 resin hit 96% purity, 81% recovery, stayed stable for 25 cycles, & leaked <1.7 ng/mL ligand. A leap forward for scalable rHBsAg-VLP production. Read more: https://jotbody.com/can-nanobodies-innovate-large-scale-vaccine-purification/

05 Aug 2025 02:30 +0000

❓ What if CRISPR could be delivered safely to brain cells without virus? A new EV platform shows >40% hippocampal editing in vivo—game changer. 📖 Read more: https://jotbody.com/are-evs-the-new-frontier-for-delivering-genome-editors-and-therapeutic-payloads/

30 Jul 2025 02:19 +0000

VS2 nanobody resin binds 16.23 mg/mL of SUMO fusion protein, works across eight targets, and retains >80% capacity after 25 NaOH cleans. Efficient purification, redefined. 🔗 https://jotbody.com/can-nanobody-resin-revolutionize-sumo-tagged-protein-purification/

29 Jul 2025 02:57 +0000

Can dopamine coated EVs target dopamine neurons and stop Parkinson’s damage? 🔬 Dopa EVs show targeted uptake, rescue dopaminergic neurons, and trigger protective autophagy in mouse PD models. https://jotbody.com/can-dopamine-modified-evs-rescue-dopamine-neurons-in-parkinsons-disease/

23 Jul 2025 02:34 +0000

Could EVs carry RNA therapies—safely & efficiently without viruses? ✅ EVs deliver miRNA, mRNA, and CRISPR guides across the BBB & tumors with low immune risk. Read more about the review: https://jotbody.com/could-extracellular-vesicles-evs-redefine-gene-therapy-through-rna-delivery/

22 Jul 2025 02:53 +0000

🚀 Nanobody + quantum microspheres detect aflatoxin B₁ at 0.03 ng/mL in just 8 min—10× more sensitive than gold strips! Precision food safety, no lab needed. 🔗 https://jotbody.com/is-your-food-safety-test-sensitive-enough/

16 Jul 2025 06:12 +0000

🧬Nanobody-based AuNP cluster LFIA rapidly detects survivin in urine—LOD just 3.90 ng/mL. Fast, stable & precise bladder cancer diagnosis in minutes, no labs needed! 🔗https://jotbody.com/can-nanobody-strips-outsmart-invasive-bladder-cancer-tests/ #Nanobody #IVD #BladderCancer #Diagnostics #RapidTest

09 Jul 2025 03:47 +0000

🔬 Nanobody rapid test detects NMP22 & survivin for bladder cancer: • 100% sensitivity, 90.9% specificity (dual marker strip) • Visual results in minutes 📖 Read:https://jotbody.com/can-a-nanobody-urine-strip-outperform-invasive-bladder-cancer-screening/

08 Jul 2025 02:54 +0000

🧬 Modular EV targeting breakthrough: Fc EVs (antibody decorated) show 339 times cancer cell uptake & 180 times tumor accumulation, delivering doxorubicin effectively in mice. A new era for precision EV therapies. 🔗 https://jotbody.com/can-antibody-decorated-evs-deliver-drugs-with-180-times-tumor-targeting-efficiency/ #ExtracellularVesicles #CancerTherapy

03 Jul 2025 06:18 +0000

✨ Nanobody Breakthrough in Zika Detection! 🦠 Nanobody test detects 1 ng/mL Zika NS1, results in 15 minutes ⏱️, no Dengue cross-reaction. Affordable, portable, and stable for 28 days 🌡️—ideal for self-testing. 🔗 https://jotbody.com/could-a-small-nanobody-be-the-key-to-ultra-sensitive-portable-virus-testing/ #Nanobody #IVD #Diagnostics #Zika

02 Jul 2025 06:14 +0000

🧬 Hybrid EVs hit ≈40% loading efficiency for siRNA/plasmids using a 30-min pH-triggered fusion with LCNPs—double the performance of passive methods. Surface proteins and function intact. 🔗 https://jotbody.com/why-loading-nucleic-acids-into-evs-is-so-hard-and-how-researchers-doubled-efficiency-to-40/ #EVResearch #GeneDelivery

24 Jun 2025 07:25 +0000

🎯 Nanobody raises extracellular pH by ~0.11 units 🚫 Blocks invasion (Ki ≈ 15.6 nM) 🌬 Lung metastasis drops 50% → 13% in mice (~74% reduction) ✅ No tumor shrinkage or toxicity Oncotarget study 👇 https://jotbody.com/could-one-tiny-nanobody-stop-breast-cancer-from-spreading-to-the-lungs/

24 Jun 2025 02:54 +0000

🚨 Storing EVs in plain PBS? You might be losing 50–90% of your sample—even at –80 °C. 💡 Add albumin + trehalose, and get 75–95% recovery—even after 26 weeks. Don’t let your buffer cost you results! 🔗 https://jotbody.com/is-your-ev-storage-buffer-causing-the-loss-of-up-to-90-of-your-sample/

17 Jun 2025 02:23 +0000

🧊 Lyophilizing EVs without protection kills ~40% of vesicles and degrades miRNAs. 🧪 Adding trehalose or mannitol preserves structure, cargo, and enzyme activity—even at room temp. 📦 Room-temp EV storage = cost savings + broader access. 🔗 Read the full study: https://jotbody.com/whats-the-recommended-approach-for-lyophilizing-evs-to-guarantee-recovery-and-performance/

10 Jun 2025 02:31 +0000

🔬 How strong is your EV lysis buffer? Mild buffer gently extracts surface markers like CD55/CD59. Moderate buffer boosts tetraspanins (CD9/CD81/CD63). Need deep cargo? Harsher lysis works—but requires cleanup. Which are you using? 🤔 https://jotbody.com/choose-wisely-to-unlock-biomarkers/

03 Jun 2025 09:21 +0000

Nanobodies are revolutionizing cancer therapy by targeting the tumor microenvironment for precise drug delivery, including: Glioblastoma Invasion Inhibition Enhanced Imaging in Gastric Cancer Targeted Photodynamic Therapy Discover the latest research: https://jotbody.com/nanobodies-precision-tools-targeting-the-tumor-microenvironment/

03 Jun 2025 02:32 +0000

Storing EVs in PBS leads to ~40% loss over 10 weeks. PBS + 30% Glycerol: 22.7% reduction PBS + 6% DMSO: 16.4% reduction PBS + 25 mM Trehalose: Less than 10% reduction. Optimize your EV storage today! https://jotbody.com/enhancing-extracellular-vesicle-preservation-the-role-of-cryoprotectants/

27 May 2025 02:03 +0000

Milk-derived extracellular vesicles (mEVs) offer natural therapeutic benefits and can be engineered for targeted drug delivery, including oral administration. Learn more: https://link.springer.com/article/10.1186/s44301-025-00005-5

20 May 2025 02:47 +0000

Bovine milk-derived EVs combat K. pneumoniae-induced oxidative stress & ferroptosis in bMECs, offering a natural mastitis remedy. Study: https://jotbody.com/bovine-milk-derived-extracellular-vesicles-a-natural-defense-against-mastitis/ https://jasbsci.biomedcentral.com/articles/10.1186/s40104-025-01151-7

13 May 2025 10:01 +0000

Can humanized nanobodies match native performance? Yes! A 2024 study shows CD19 CAR-Ts with humanized VHHs retained full cytotoxicity. 🔗 https://jotbody.com/can-humanized-nanobodies-match-native-performance-in-car-t-therapies/

13 May 2025 06:45 +0000

Plant nanoparticles from red cabbage cut gut inflammation by 50%! Engineered vesicles safely targeted and repaired colon damage orally. Future IBD treatment? 🌿 https://jotbody.com/plant-derived-extracellular-vesicles-target-and-tame-gut-inflammation/

06 May 2025 16:13 +0000

Researchers engineered two nanobodies that bind to Ebola to neutralise viral particles in vitro. 🚀 The result: •⁠ ⁠Animal Survival: 50% longer survival day. •⁠ ⁠Viral Load Reduction: Up to 1,000-fold decrease. Read more about the study: https://jotbody.com/event_categories/latest-research/

06 May 2025 04:32 +0000

🌳 Plant-derived extracellular vesicles (PDEVs) are emerging as sustainable, biocompatible nanocarriers for drug delivery. 📖 Dive into the latest research: https://jotbody.com/plant-derived-extracellular-vesicles-natures-nanocarriers-for-advanced-drug-delivery/

22 Apr 2025 05:55 +0000

With a projected CAGR of 18.5%, the global extracellular vesicle market. With a projected compound annual growth rate (CAGR) of 18.5%, the global EV Diagnostics & Therapeutics market EV market is expected to reach $3.28 billion by 2030. Read more: https://jotbody.com/the-booming-ev-market-trends-insights-ahead-of-isev-2025/

22 Apr 2025 05:53 +0000

🥜 Are your current food allergen detection methods sensitive and reliable enough? A recent review in Food Quality and Safety demonstrates that nanobody-based immunoassays are setting new standards for food allergen surveillance. Read more : https://jotbody.com/nanobodies-revolutionizing-food-allergen-surveillance/

09 Apr 2025 02:11 +0000

🦈 Shark - derived nanobodies target CD22 in cancer immunotherapy. Conventional CD22 - positive B - cell malignancy therapies have issues. CD22 is a great immunotherapy target. A study in Molecular Therapy – Oncolytics by Scott McComb, Read more: https://jotbody.com/revolutionize-cancer-immunotherapy-how-shark-derived-nanobodies-target-cd22-to-solve-critical-therapeutic-challenges/

01 Apr 2025 07:23 +0000

Are Alpaca Overuse Hurting #Nanobody Innovation? 🦙✨ Nanobody research is growing, but are we overusing alpacas? A new China report reveals problems: 🔗 Read Report: https://jotbody.com/the-challenges-of-overusing-alpacas-in-nanobody-research/