Our research focuses on neurological disease modeling using human pluripotent stem cells, with a focus on glial cells.https://bsky.app/profile/krzischlab.bsky.socialhttps://bsky.app/profile/krzischlab.bsky.social/post/3mrqd4znt622pOur collaboration with Franck Polleux's lab is now out in Neuron! The human brain is characterized by prolonged development. Here, C. Diaz-Salazar shows that human-specific SRGAP2B/SRGAP2C genes slow microglial development, delaying the formation of synapses in humans. https://www.cell.com/neuron/fulltext/S0896-6273(26)00536-228 Jul 2026 21:10 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3mrqd4znt622phttps://bsky.app/profile/krzischlab.bsky.social/post/3mkruhcu7sk2eA position of Lecturer (assistant professor) in neuroscience is now available at the School of Biomedical Sciences at the University of Leeds. The University of Leeds is leading, research intensive university in the UK. Please apply through this link if interested: https://jobs.leeds.ac.uk/vacancy.aspx?ref=FBSBM122901 May 2026 09:57 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3mkruhcu7sk2ehttps://bsky.app/profile/krzischlab.bsky.social/post/3m6z4tpc2ac2mGreat post-doctoral opportunity at the Norwegian Center for Stem Cell Research at Oslo University Hospital (co-lead between Dr. Kaja Nordengen at Oslo University Hospital, OUS-Research.no/tng and Prof. Joel Glover at University of Oslo): https://www.jobbnorge.no/en/available-jobs/job/290362/postdoctoral-fellowship-in-in-vitro-human-ips-cell-based-neurodegenerative-disease-modeling https://lnkd.in/emDUZxBP02 Dec 2025 14:13 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3m6z4tpc2ac2mhttps://bsky.app/profile/krzischlab.bsky.social/post/3m4xytao5s227A PhD project co-supervised by Dr. Jamie Johnston is available in my lab. This project offers a unique opportunity to pioneer the world’s first in vivo model of human neuron–microglia interactions. To know more and apply: https://www.findaphd.com/phds/project/building-the-first-in-vivo-model-of-human-neuron-microglia-interactions/?p190305 Deadline: 07.01.2026, 5pm (UK time)06 Nov 2025 16:38 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3m4xytao5s227https://bsky.app/profile/krzischlab.bsky.social/post/3m4jhuhgw2c2aDr. Matthew Livesey (main supervisor), Dr. Scott Allen (co-supervisor), I (co-supervisor) and Prof. Dame Pamela Shaw (co-supervisor) are advertising a PhD project on the role of astrocytes in Motor Neuron Disease. It is open to UK and international students. https://www.findaphd.com/phds/project/mrc-dimen-doctoral-training-partnership-understanding-how-connexin-dysfunction-in-astrocytes-influences-disease-progression-heterogeneity-in-motor-neuron-disease/?p188722 https://lnkd.in/ezqmgT-p31 Oct 2025 21:57 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3m4jhuhgw2c2ahttps://bsky.app/profile/krzischlab.bsky.social/post/3m4jhofjdwc2aI am advertising a PhD project on the role of microglia in Parkinson's, using cryoEM and transplantation models. It is open to UK and international students. https://www.findaphd.com/phds/project/mrc-dimen-doctoral-training-partnership-using-cryoem-and-the-transplantation-of-human-microglia-in-the-mouse-brain-to-decode-microglial-dysfunction-in-parkinson-s-disease/?p189374 Deadline for applications: Thursday 4th December 2025 at 1pm. https://lnkd.in/ePjnRc3E31 Oct 2025 21:54 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3m4jhofjdwc2ahttps://bsky.app/profile/krzischlab.bsky.social/post/3m364vhbzbc2yhttps://www.nature.com/articles/s41586-025-09542-614 Oct 2025 16:17 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3m364vhbzbc2yhttps://bsky.app/profile/krzischlab.bsky.social/post/3lykw5k7hec2oOur Master student Abigail King just passed her viva with flying colours. During her stay, she cultured and differentiated hiPSC into microglia before analysing them using immunofluorescence stainings, and made excellent contributions to our lab. She is now looking for a PhD position in the UK.11 Sep 2025 14:05 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3lykw5k7hec2ohttps://bsky.app/profile/krzischlab.bsky.social/post/3lupxee523k2dThe Krzisch Lab just received the LEAF Gold award! This award rewards laboratories that take actions to improve their environmental sustainability and efficiency. Our sustainability efforts have allowed us to save a good amount of money as a lab. https://krzischlab.wordpress.com/wp-admin/post.php?post=37&action=edit24 Jul 2025 16:29 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3lupxee523k2dhttps://bsky.app/profile/krzischlab.bsky.social/post/3ltyzyfeqrc2mThe Krzisch lab’s website has been launched! https://krzischlab.wordpress.com/2025/07/14/hello-world/15 Jul 2025 13:45 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3ltyzyfeqrc2mhttps://bsky.app/profile/krzischlab.bsky.social/post/3ltlosmlc5k2bhttps://www.leeds.ac.uk/main-index/news/article/5815/university-granted-sanctuary-status10 Jul 2025 06:20 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3ltlosmlc5k2bhttps://bsky.app/profile/krzischlab.bsky.social/post/3lsgbik4wxs2hhttps://www.nature.com/articles/d41586-025-01966-4?utm_source=facebook&utm_medium=social&utm_campaign=nature&linkId=15380119&fbclid=IwZXh0bgNhZW0CMTEAAR4sILTM1xBTnzwjhmFUWZukzTBv1Z9apMKLM6muQEDDNkznkbnuTqQk_4qDxA_aem_R0c3ayX4hWsoCwflcgwMSw25 Jun 2025 09:13 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3lsgbik4wxs2hhttps://bsky.app/profile/krzischlab.bsky.social/post/3lrjc377nos2xI am honored to receive funding from the Autism Science Foundation/FRAXA. Our project will explore the role of microglia in Fragile X syndrome, a leading cause of autism and intellectual disability, by transplanting human microglia into mouse brains. www.fraxa.org?p=38876&prev... https://www.fraxa.org/?p=38876&preview=1&_ppp=1859da4ccb13 Jun 2025 20:37 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3lrjc377nos2xhttps://bsky.app/profile/krzischlab.bsky.social/post/3lrbegzftj22eThe Krzisch lab just received the LEAF Bronze award! This award rewards laboratories that improve their environmental sustainability. We are now working towards the Silver award. Here is more information about the LEAF: https://www.ucl.ac.uk/sustainable/take-action/staff-action/leaf-laboratory-efficiency-assessment-framework @universityofleeds.bsky.social10 Jun 2025 16:58 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3lrbegzftj22ehttps://bsky.app/profile/krzischlab.bsky.social/post/3lmrz3wqx5c2tThe Autism Science Foundation just released a podcast where Dr. Alycia Halladay was joined by I and Dr. Michael Tranfaglia from the FRAXA Research Foundation. We discussed Fragile X syndrome and how microglia, the brain's immune cells, might be a key player in this disorder: lnkd.in/eZfKsHJw https://lnkd.in/eZfKsHJw14 Apr 2025 16:44 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3lmrz3wqx5c2thttps://bsky.app/profile/krzischlab.bsky.social/post/3ll7m7v5g422oI really enjoyed reading the early-career investigator commentary by Dr. Claudia Z. Han (WashU) on our recent paper in Biological Psychiatry: https://www.biologicalpsychiatryjournal.com/article/S0006-3223(25)00057-5/fulltext . We are indeed planning to follow some of the further research directions that were suggested.25 Mar 2025 15:40 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3ll7m7v5g422ohttps://bsky.app/profile/krzischlab.bsky.social/post/3lkkvtxl53k2gOur article has now been published in Biological Psychiatry, and one of our pictures made the cover again :) https://www.biologicalpsychiatryjournal.com/article/S0006-3223(24)01459-8/fulltext17 Mar 2025 10:07 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3lkkvtxl53k2ghttps://bsky.app/profile/krzischlab.bsky.social/post/3lilzhx3xsk27A post-doctoral position is available in the lab of Dr. Kaja Nordengen at the University of Oslo: https://www.jobbnorge.no/en/available-jobs/job/274391/postdoctoral-fellowship-in-in-vitro-human-ips-cell-based-neurodegenerative-disease-modeling20 Feb 2025 09:54 +0000at://did:plc:hhf2z7qbwqsoeupjp5x34map/app.bsky.feed.post/3lilzhx3xsk27