Vaccines and immune system scientist. Professor and Chief Scientific Officer (CSO), La Jolla Institute for Immunology (LJI), a non-profit research institute.https://bsky.app/profile/profshanecrotty.bsky.socialhttps://bsky.app/profile/profshanecrotty.bsky.social/post/3mjhqdw23tc2pThanks Eric! I worked to make this review of human immune memory to vaccines comprehensive and accessible. And I made an accompanying video lecture for those desiring a different format: https://www.youtube.com/watch?v=8DeZJ6V7nuI [contains quote post or other embedded content]14 Apr 2026 15:51 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3mjhqdw23tc2phttps://bsky.app/profile/profshanecrotty.bsky.social/post/3mjhqatv53k2pMy new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy! @lji.org @cp-immunity.bsky.social https://authors.elsevier.com/sd/article/S107476132600089014 Apr 2026 15:50 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3mjhqatv53k2phttps://bsky.app/profile/profshanecrotty.bsky.social/post/3m5hg32b2mk22In our latest study in @cp-immunity.bsky.social, we followed dynamics of vaccine-specific Tfh cells for 60+ weeks after immunization. https://authors.elsevier.com/a/1m3mV3qNrU-iTH We captured >500,000 CD4 T cells including >36,000 vaccine-specific Tfh by scRNAseq, giving an unprecedented longitudinal detail.12 Nov 2025 19:45 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3m5hg32b2mk22https://bsky.app/profile/profshanecrotty.bsky.social/post/3m5hfog7pec22thanks! [contains quote post or other embedded content]12 Nov 2025 19:38 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3m5hfog7pec22https://bsky.app/profile/profshanecrotty.bsky.social/post/3m3n46vpdfc2tLJI is recruiting! The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.20 Oct 2025 15:14 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3m3n46vpdfc2thttps://bsky.app/profile/profshanecrotty.bsky.social/post/3m3n2fhbvfk2dIn our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. https://www.science.org/doi/10.1126/sciimmunol.adu8878 @scienceimmuno.bsky.social @lji.org20 Oct 2025 14:42 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3m3n2fhbvfk2dhttps://bsky.app/profile/profshanecrotty.bsky.social/post/3lydfwebss22k1/ David Baltimore passed away this weekend. He was one of the greatest biologists of the past 100 years. He made extraordinary contributions to immunology, cancer, molecular biology, virology, HIV, biochemistry, genetics, and genetic engineering. He won the Nobel prize in Medicine at age 37.08 Sep 2025 14:26 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3lydfwebss22khttps://bsky.app/profile/profshanecrotty.bsky.social/post/3lveduzek322hA good news article in Nature today following up on these papers https://www.nature.com/articles/d41586-025-02439-4 [contains quote post or other embedded content]01 Aug 2025 19:06 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3lveduzek322hhttps://bsky.app/profile/profshanecrotty.bsky.social/post/3lv7dkdbn532shttps://www.statnews.com/2025/07/30/mrna-hiv-vaccine-study-science-translational-medicine/30 Jul 2025 19:17 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3lv7dkdbn532shttps://bsky.app/profile/profshanecrotty.bsky.social/post/3lv7dggicys2sAfter 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people. * "Tier 2" neutralizing antibodies, induced consistently. https://www.science.org/doi/10.1126/scitranslmed.adw0721 https://www.science.org/doi/10.1126/scitranslmed.ady683130 Jul 2025 19:15 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3lv7dggicys2shttps://bsky.app/profile/profshanecrotty.bsky.social/post/3luiacorkxc2kIn our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations https://www.biorxiv.org/content/10.1101/2025.07.14.664794v121 Jul 2025 14:48 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3luiacorkxc2khttps://bsky.app/profile/profshanecrotty.bsky.social/post/3lo772kwlnk2rOur wonderful LJI colleague Alex Sette was knighted this week! In recognition of his extraordinary contributions to immunology. As one measure of Alex's impact on immunology, he has over 140,000 scientific citations, and has 964 papers that have been cited at least 10 times. [contains quote post or other embedded content]02 May 2025 16:00 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3lo772kwlnk2rhttps://bsky.app/profile/profshanecrotty.bsky.social/post/3lma44i76l22mOne of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper… @cp-immunity.bsky.social https://www.cell.com/immunity/fulltext/S1074-7613(25)00121-907 Apr 2025 13:50 +0000at://did:plc:hnhqo7zvpkgpyvc4bqqd5i4x/app.bsky.feed.post/3lma44i76l22m