Our lab seeks an agile and predictive understanding of how RNAs structurally code for information processing and replication in living systems.https://bsky.app/profile/rdaslab.bsky.socialhttps://bsky.app/profile/rdaslab.bsky.social/post/3mlgpxwq7tk2rThe 2nd week of #CASP17 is closing, with more group II introns and some other RNAmake synthetic designs — the dimer targets for both kinds of targets seem challenging! And more #RNA targets are coming in week 3: predictioncenter.org/news.cgi#55709 May 2026 17:02 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3mlgpxwq7tk2rhttps://bsky.app/profile/rdaslab.bsky.social/post/3ml55e5iki22zLatest #CASP17 #RNA targets are a tiny aptamer for tryptophan selected by Yarus lab @colorado.edu, a miniTTR by RNAmake @josephyesselman.bsky.social, and 2 singlet glycine riboswitches discovered by Breaker & Strobel labs. Note first one: 25-nt RNA by #cryoEM? https://predictioncenter.org/casp17/targetlist.cgi?view=rna05 May 2026 21:35 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3ml55e5iki22zhttps://bsky.app/profile/rdaslab.bsky.social/post/3mkuxw4xtgk2rFirst natural #RNA in #CASP17 is a group II self-splicing intron, and it’s also the season's 1st multistate target! Will server algorithms detect homologous group II intron structures to help modeling? Can servers model both unspliced and spliced states? https://predictioncenter.org/casp17/targetlist.cgi?view=rna02 May 2026 15:37 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3mkuxw4xtgk2rhttps://bsky.app/profile/rdaslab.bsky.social/post/3mkq546bsdc23More #CASP17 #RNA targets: OpenKnot @eternagame molecules from AI designers @rosettacommons.bsky.social @chaitjo.bsky.social & triphosphorylating ribozyme selected by Muller lab. All 8 RNA targets are non-natural — how will modeling methods do without MSAs, templates, homologous training examples?30 Apr 2026 17:26 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3mkq546bsdc23https://bsky.app/profile/rdaslab.bsky.social/post/3mkj2vjq3bk2qFirst two targets in #CASP17 are #RNA, and they're designs from the online videogame @eternagame.org. Hope the bots preparing for CASP have been playing Eterna!27 Apr 2026 21:58 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3mkj2vjq3bk2qhttps://bsky.app/profile/rdaslab.bsky.social/post/3mkgl7uey2s2hThe 17th Critical Assessment of Structure Prediction #CASP17 begins tomorrow. 2 #RNA targets per day for next few weeks! >60 servers registered already, including @kaggle teams. Join the fun at predictioncenter.org/casp17/ https://predictioncenter.org/casp17/26 Apr 2026 22:12 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3mkgl7uey2s2hhttps://bsky.app/profile/rdaslab.bsky.social/post/3miexoosg4k2mResults are in for @stanfordmedicine.bsky.social Kaggle #RNA 3D Folding, Part 2! Top teams team_cp and AyPy together just outperform the best template oracle, another milestone in computational biology. Come join the conversation as we prepare for #CASP17: https://www.kaggle.com/c/stanford-rna-3d-folding-2/discussion/68659031 Mar 2026 19:59 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3miexoosg4k2mhttps://bsky.app/profile/rdaslab.bsky.social/post/3mdy6lwvx7k2iFirst public presentation of (Part 1 of) the #Kaggle 3D #RNA Folding challenge results -- see you Thursday! [contains quote post or other embedded content]03 Feb 2026 20:18 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3mdy6lwvx7k2ihttps://bsky.app/profile/rdaslab.bsky.social/post/3md74zgxovc2yIn 2 weeks, 9 Kaggle teams have beat AlphaFold 3 score (0.372) in predicting hidden 3D structures of #RNA, including complexes with small molecules & proteins. What will it take to beat the best template oracle (0.554)? https://www.kaggle.com/c/stanford-rna-3d-folding-224 Jan 2026 21:13 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3md74zgxovc2yhttps://bsky.app/profile/rdaslab.bsky.social/post/3mbwbe72r6k2hInspired by 2025 Stanford #RNA 3D folding @kaggle challenge outcome, we’ve collected cryo-EM of new-to-Nature RNA folds, RNA complexes with small molecules and proteins, and assemblies up to 6000 nts - and launched PART 2! Deadline: March 2026. https://www.kaggle.com/c/stanford-rna-3d-folding-2/08 Jan 2026 15:11 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3mbwbe72r6k2hhttps://bsky.app/profile/rdaslab.bsky.social/post/3mbc3qmyhyk2rPreprint on the Stanford #RNA 3D folding Kaggle challenge is out. My scientific new year’s resolution is to brush up on template-based modeling. #gofai https://www.biorxiv.org/content/10.64898/2025.12.30.696949v131 Dec 2025 14:38 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3mbc3qmyhyk2rhttps://bsky.app/profile/rdaslab.bsky.social/post/3m6dta6p7bk2kWonderful collab with Fu and Zuchero labs, led by @vedtopkar.bsky.social in our lab. How do molecules make it out to the myelin sheath? For the most expressed protein in oligodendrocytes, an #RNA switch appears to be the answer. Meng-meng's posts explain it best! [contains quote post or other embedded content]24 Nov 2025 02:55 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3m6dta6p7bk2khttps://bsky.app/profile/rdaslab.bsky.social/post/3m5gwkrru6c2s@eternagame got single RNAs to compute functions like all logic gates, A>B, and A*B/C^2, relevant for tuberculosis detection! Now looking for partners to scale to complex applications. Collab w/ Greenleaf Khatri labs @christianchoe.bsky.social @stanfordmedicine.bsky.social at https://doi.org/10.1038/s41557-025-01907-812 Nov 2025 15:08 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3m5gwkrru6c2shttps://bsky.app/profile/rdaslab.bsky.social/post/3m5cwdkkhf22n#MD blind predictions of water/ions around Tetrahymena ribozyme #RNA matched cryo-EM data better than our baselines! Congrats #CASP16 + @rachael-kretsch.bsky.social + 23 brave groups. Still a ways to go — time for #DeepLearning of water? Community paper: https://doi.org/10.1002/prot.7007911 Nov 2025 00:53 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3m5cwdkkhf22nhttps://bsky.app/profile/rdaslab.bsky.social/post/3m4gn7xq5xk2vAssessment of blind 3D structure modeling of #RNA and nucleic acid complexes now out in the #CASP16 special issue, led by @RachaelKretsch. We hope this benchmark, paper, metrics, and expert baselines drive much-needed progress by #CASP17 (May 2026)! http://doi.org/10.1002/prot.7007230 Oct 2025 18:55 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3m4gn7xq5xk2vhttps://bsky.app/profile/rdaslab.bsky.social/post/3lzltt3tx3k25The results are in: top codes in Stanford #RNA 3D Folding @kaggle.com competition are competitive with CASP16-leading humans Vfold, beat AlphaFold 3. Top team’s trick was template-based modeling, not #DeepLearning. Congrats: john, odat, Eigen, + all 1706 participants! https://www.kaggle.com/competitions/stanford-rna-3d-folding/discussion/60918724 Sep 2025 16:21 +0000at://did:plc:hv2xuxdevrfohaw77ylrlur4/app.bsky.feed.post/3lzltt3tx3k25