To those lacking effective treatment options: We hear you. And we are relentlessly driving toward much-needed solutions. #MELAS #MitochondrialDiseasehttps://bsky.app/profile/tisentotx.bsky.socialhttps://bsky.app/profile/tisentotx.bsky.social/post/3mh6gpqaqx62yIt’s #BrainAwarenessWeek! Many #MitochondrialDiseases can have negative implications for brain health. That’s because the brain requires a massive amount of energy, which can only be sufficiently produced when mitochondria are functioning well. #UMDF #Biosky16 Mar 2026 12:15 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3mh6gpqaqx62yhttps://bsky.app/profile/tisentotx.bsky.social/post/3mgpd4zk2ki2lLearnings from #RareDisease #ClinicalDevelopment are shaping the future of medicine– from sharpened trial design discipline and innovation to deepened collaborations with patients, families, and other stakeholders around the world. #WeHearYou #Biosky https://www.the-scientist.com/what-rare-disease-research-teaches-us-about-the-future-of-precision-medicine-7410010 Mar 2026 12:01 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3mgpd4zk2ki2lhttps://bsky.app/profile/tisentotx.bsky.social/post/3mfw6hzzy422gToday is #RareDiseaseDay. We stand with the 300 million people globally who live with a rare disease, including those with rare #MitochondrialDiseases like #MELAS. Read stories of #RareDisease heroes: www.rarediseaseday.org/heroes/ #Biosky28 Feb 2026 12:01 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3mfw6hzzy422ghttps://bsky.app/profile/tisentotx.bsky.social/post/3mfjzmga3sd2vThere are 6,000+ rare diseases—and expertise and information are often scarce. In health systems designed for common diseases, rare diseases often face inequities. https://download2.rarediseaseday.org/2025/campaign_materials/Toolkits/Equity_Toolkit.pdf #RareDiseaseDay #HealthEquity #MitochondrialDisease #MELAS #Biosky https://youtu.be/7J1oTfoIOGw23 Feb 2026 16:02 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3mfjzmga3sd2vhttps://bsky.app/profile/tisentotx.bsky.social/post/3meizg3sux42jThe #MELAS Externally Led Patient-Focused Drug Development meeting is today! Hosted by #MitoAction, the event invites those affected by MELAS to share their experiences and be part of shaping #MitochondrialDisease care and treatment. https://www.mitoaction.org/join-the-cause/patient-focused-drug-development-meeting-on-melas/ #Biosky10 Feb 2026 13:00 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3meizg3sux42jhttps://bsky.app/profile/tisentotx.bsky.social/post/3me4h7tia2f2eNext week, #MitoAction is hosting an Externally Led Patient-Focused Drug Development meeting dedicated to #MELAS. We’re proud to sponsor this important opportunity to elevate MELAS voices. Virtual event open to all! Register: https://www.mitoaction.org/join-the-cause/patient-focused-drug-development-meeting-on-melas/ #Biosky05 Feb 2026 13:03 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3me4h7tia2f2ehttps://bsky.app/profile/tisentotx.bsky.social/post/3mcx6oxovvc23We believe meaningful innovation starts with listening. That’s why we’re conducting an interview study with adolescents (12-17 years) who are living with #MELAS, a rare #MitochondrialDisease. The final group is enrolling now! https://www.tisentotx.com/s/Tisento-Ado-Flyer-Aug24-TEENAPPROVED.pdf #biosky21 Jan 2026 17:22 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3mcx6oxovvc23https://bsky.app/profile/tisentotx.bsky.social/post/3mchod5aw322xWhat will 2026 bring for the #MitochondrialDisease community? Join the @MitoAction town meeting on Friday to hear insights from advocates, clinicians, and industry leaders, including our VP of Program Leadership, Jennifer Chickering. Register here: https://www.mitoaction.org/resources/2026-mito-town-meeting/ #Biosky #MELAS15 Jan 2026 13:19 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3mchod5aw322xhttps://bsky.app/profile/tisentotx.bsky.social/post/3mbvxaz2q722qWe’ve completed enrollment in PRIZM, our global Phase 2b study evaluating our investigational medicine’s impact on fatigue and cognitive function in MELAS – a #RareDisease that currently has no approved treatments. #MitochondrialDisease #Biosky https://www.tisentotx.com/news/tisento-therapeutics-completes-enrollment-in-prizm-a-global-phase-2b-study-of-zagociguat-for-the-treatment-of-melas08 Jan 2026 12:11 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3mbvxaz2q722qhttps://bsky.app/profile/tisentotx.bsky.social/post/3malb7jibzc2uThis year was filled with momentum and meaningful moments as we worked alongside the #MitochondrialDisease community to amplify MELAS voices and advance our mission to deliver medicines that can address what matters most. Take a look at our #2025Wrapped. #WeHearYou #BioSky22 Dec 2025 12:44 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3malb7jibzc2uhttps://bsky.app/profile/tisentotx.bsky.social/post/3m7hrioddr52wTune into today’s UMDF Bench-to-Bedside Clinical Trials Update! Chad Glasser, our VP of Clinical Research, will share an update on our Phase 2b PRIZM study in MELAS. #Biosky https://www.umdf.org/event/umdf-bench-to-bedside-clinical-trials-update-part-2/08 Dec 2025 10:00 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3m7hrioddr52whttps://bsky.app/profile/tisentotx.bsky.social/post/3m6mhaptd522pOn U.S. Thanksgiving, we want to say thank you to our global community who partner with us on our mission to develop medicines that address what matters most. Thank you to those living with MELAS, their loved ones, advocates, healthcare providers, and our team! #Biosky #Thanksgiving202527 Nov 2025 13:15 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3m6mhaptd522phttps://bsky.app/profile/tisentotx.bsky.social/post/3m63rysu56s2fThanks, @MitoCanada, for creating an accessible, community-friendly summary of our interview study with adults who have MELAS! #MitochondrialDisease #MitoInsights #WeHearYou #Biosky https://mitocanada.org/signs-symptoms-and-health-related-quality-of-life-in-melas/20 Nov 2025 22:12 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3m63rysu56s2fhttps://bsky.app/profile/tisentotx.bsky.social/post/3m5e64dsxxk2cTomorrow, Chad Glasser, VP of Clinical Research, will present at the Wellcome Mitochondrial Medicine Conference on assessing cognitive function in #PrimaryMitochondrialDisease clinical trials. #MELAS #ClinicalDevelopment #Biosky https://coursesandconferences.wellcomeconnectingscience.org/event/mitochondrial-medicine-therapeutic-development-20251110/11 Nov 2025 12:45 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3m5e64dsxxk2chttps://bsky.app/profile/tisentotx.bsky.social/post/3m4pysbe7ac24Findings from our #MELAS interview study were recently published in the Journal of Patient-Reported Outcomes. The study highlighted the symptoms & impacts most important to patients and informed our Phase 2b PRIZM study. #MitochondrialDisease #PRO #Biosky https://www.tisentotx.com/news/tisento-therapeutics-announces-publication-of-melas-interview-study-incorporating-patients-perspectives-to-elucidate-symptoms-and-impacts-of-rare-mitochondrial-disease03 Nov 2025 12:16 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3m4pysbe7ac24https://bsky.app/profile/tisentotx.bsky.social/post/3m4awootqwt2iMeet Roberto and Anna! Married for 30+ years, they support one another through Roberto’s journey with MELAS. We’re honored to support #MitoCon in telling stories of those affected by this #RareDisease. See their story (Italian w/ English subtitles): youtu.be/mwkczr_QDxg #Biosky https://youtu.be/mwkczr_QDxg28 Oct 2025 12:29 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3m4awootqwt2ihttps://bsky.app/profile/tisentotx.bsky.social/post/3m3ugx7q7rc2dMeet Morena! She’s a mom and a retired nurse, loves deeply connecting with people, and lives with #MELAS. We’re honored to support #MitoCon in telling stories of those affected by this #RareDisease. See Morena’s story (Italian w/ English subtitles): youtu.be/bFciPejLNPg #Biosky https://youtu.be/bFciPejLNPg23 Oct 2025 13:15 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3m3ugx7q7rc2dhttps://bsky.app/profile/tisentotx.bsky.social/post/3lznvxhuk3p2zLast call for our PRIZM clinical study in #MELAS! We’re expecting to complete enrollment in the next few weeks. Those who are interested in participating at one of our sites around the world can find out more by talking to their doctor. #ClinicalResearch #MitochondrialDisease www.tisentotx.com/prizm25 Sep 2025 12:05 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lznvxhuk3p2zhttps://bsky.app/profile/tisentotx.bsky.social/post/3lzgidd5qe225It was so inspiring to see so many people around the world sharing stories and raising awareness about #MitochondrialDisease during #WorldMitoWeek2025. We’re honored to be part of such a wonderful global community. #DecodeTheMitoPuzzle #LightUpForMito #BioSky [contains quote post or other embedded content]22 Sep 2025 13:12 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lzgidd5qe225https://bsky.app/profile/tisentotx.bsky.social/post/3lzcbl7hwk72jTo us, #LightUpForMito is personal. While monuments and landmarks around the world are lit up in green, we’re lighting up our homes, our pets, and ourselves. We stand with the #MitochondrialDisease community! #WorldMitoWeek2025 #DecodeThePuzzle #Biosky20 Sep 2025 21:01 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lzcbl7hwk72jhttps://bsky.app/profile/tisentotx.bsky.social/post/3lzblqnxwtx2wTonight, landmarks, buildings & monuments around the world will light up in GREEN to shine a light on #MitochondrialDiseases. This display raises visibility, sparks conversations & shows solidarity with the mito community. #LightUpForMito #WorldMitoWeek2025 #Biosky https://mitopatients.org/light-up-for-mito/#2025-mito-map20 Sep 2025 14:30 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lzblqnxwtx2whttps://bsky.app/profile/tisentotx.bsky.social/post/3lz6ulrmzhi2wYour voice matters for those affected by #MitochondrialDisease! International Mito Patients (IMP) has practical tips and useful resources for getting involved during #WorldMitoWeek2025 and beyond! #DecodeTheMitoPuzzle #Biosky mitopatients.org/mito-week/19 Sep 2025 12:30 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lz6ulrmzhi2whttps://bsky.app/profile/tisentotx.bsky.social/post/3lz4fy4t6d52j#MELAS can affect multiple organ systems and frequently causes a range of severe and burdensome symptoms. We are working on what could be the first treatment for this devastating disease through our PRIZM MELAS study. #WorldMitoWeek2025 #MitochondrialDisease #DecodeTheMitoPuzzle #Biosky18 Sep 2025 13:03 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lz4fy4t6d52jhttps://bsky.app/profile/tisentotx.bsky.social/post/3lyzqc6roml23Collaboration among researchers, clinicians & patients translates science into real-world impact for those with #MitochondrialDisease. We’re proud to be part of this network with our PRIZM #MELAS clinical study. #WorldMitoWeek2025 #DecodeTheMitoPuzzle #Biosky www.tisentotx.com/prizm17 Sep 2025 11:30 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lyzqc6roml23https://bsky.app/profile/tisentotx.bsky.social/post/3lyxnazgu7e2rMitochondria are known as “the powerhouse of the cell,” generating ~90% of the energy our bodies need and playing a critical role in many different bodily systems and organs. #MitochondrialDiseases have broad and debilitating consequences. #WorldMitoWeek2025 #DecodeTheMitoPuzzle #Biosky16 Sep 2025 15:30 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lyxnazgu7e2rhttps://bsky.app/profile/tisentotx.bsky.social/post/3lyukggcjfn2d#WorldMitoWeek2025 starts today! This advocacy week is intended to raise awareness about #MitochondrialDiseases with a goal of improving the lives of people affected by these diseases. Join us in supporting this global community! #MitochondrialDisease #DecodeTheMitoPuzzle #Biosky15 Sep 2025 10:02 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lyukggcjfn2dhttps://bsky.app/profile/tisentotx.bsky.social/post/3lyfp2xkej62yNext week is #WorldMitoWeek2025. We love the theme, #DecodeTheMitoPuzzle, focused on connecting science to lived experiences with #MitochondrialDisease. Our PRIZM #MELAS study is rooted in this approach & is screening now but not for much longer! #WeHearYou #Biosky www.tisentotx.com/prizm09 Sep 2025 12:15 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lyfp2xkej62yhttps://bsky.app/profile/tisentotx.bsky.social/post/3lx7y4djvpy2mWe’re on a mission to deliver medicines that address what matters most for people with #MitochondrialDiseases, beginning with MELAS and our Phase 2b PRIZM study. Learn more: www.tisentotx.com/prizm #ClinicalResearch #NowEnrolling #RareDisease25 Aug 2025 12:15 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lx7y4djvpy2mhttps://bsky.app/profile/tisentotx.bsky.social/post/3lwwbwssfzk2uInterested in participating in our Phase 2b PRIZM study for adults with MELAS? We expect to complete enrollment soon, but we are still looking for a few more participants. Reach out right away! www.tisentotx.com/prizm #ClinicalResearch #MitochondrialDisease #RareDisease #Biosky21 Aug 2025 15:45 +0000at://did:plc:hy4ptr7gmkjmgvebjm2iphsv/app.bsky.feed.post/3lwwbwssfzk2u