JAMA Neurology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications. 🌐 JAMANeurology.comhttps://bsky.app/profile/jamaneurology.comhttps://bsky.app/profile/jamaneurology.com/post/3mldips2yqe2d📊 JAMA Research Summary: In acute #ischemicstroke without large or medium vessel occlusion, adjunctive #tirofiban after poor tenecteplase response increased excellent 90-day outcomes without excess bleeding or mortality. #ESOC2026 @esostroke.bsky.social ja.ma/4d6Z8nS08 May 2026 10:15 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mldips2yqe2dhttps://bsky.app/profile/jamaneurology.com/post/3mldigtcsz72vFrom @jama.com: In acute #ischemic #stroke without large/medium vessel occlusion, adjunctive IV #tirofiban after suboptimal #tenecteplase response improved excellent outcomes, with low risk of symptomatic intracranial #hemorrhage. #ESOC2026 @esostroke.bsky.social ja.ma/42UJUxv08 May 2026 10:10 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mldigtcsz72vhttps://bsky.app/profile/jamaneurology.com/post/3mld5k5ouva2yFrom @jama.com: Among adults with acute #ischemic #stroke treated 4.5 to 24 hours after onset, intravenous #tenecteplase prior to EVT did not increase functional independence or reduce disability compared with EVT alone. #ESOC2026 @esostroke.bsky.social ja.ma/48JS2o608 May 2026 06:55 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mld5k5ouva2yhttps://bsky.app/profile/jamaneurology.com/post/3mlbetammm42yPhenoconversion in #PureAutonomicFailure is associated with risk for progression to #MultipleSystemAtrophy, #ParkinsonDisease, or #LewyBodyDementia. 🎧 Learn more in this podcast episode: ja.ma/4tXKVRu https://ja.ma/4tXKVRu07 May 2026 14:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mlbetammm42yhttps://bsky.app/profile/jamaneurology.com/post/3mlb64lwlyq2v#PureAutonomicFailure carries an annual phenoconversion rate of 5% to central a-synucleinopathies including #ParkinsonDisease, #MSA, and #DLB; subtle motor signs and REM sleep behavior disorder consistently predict conversion risk. ja.ma/4wfGAKS07 May 2026 12:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mlb64lwlyq2vhttps://bsky.app/profile/jamaneurology.com/post/3ml6ueawcem2pAmong infants with genetic #Epilepsy, 16% had variants amenable to #AntisenseOligonucleotide therapies; most could be considered for precision treatment currently or at seizure onset. ja.ma/3ODbwUz06 May 2026 14:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3ml6ueawcem2phttps://bsky.app/profile/jamaneurology.com/post/3ml4dvfusgs26Delayed onset of hemichorea and dystonia can occur after cortical temporal #Stroke, even when imaging reveals small acute ischemic lesions and routine blood tests are normal. ja.ma/4tOscHX05 May 2026 14:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3ml4dvfusgs26https://bsky.app/profile/jamaneurology.com/post/3ml3zti5xta2dAmong patients younger than 55 years, recurrent #Stroke rates declined prior to 2000 but have remained stable since, indicating that further reductions in stroke recurrence may require new preventive strategies. ja.ma/4ukzseu05 May 2026 11:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3ml3zti5xta2dhttps://bsky.app/profile/jamaneurology.com/post/3ml224ytlvi2m💬 Editorial: #PureAutonomicFailure is firmly established as prodromal for central a-synucleinopathies, with mild motor signs, REM sleep behavior disorder, and bladder symptoms reliably predicting conversion to #ParkinsonDisease, #MSA, or #DLB. ja.ma/4w5UxuS04 May 2026 16:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3ml224ytlvi2mhttps://bsky.app/profile/jamaneurology.com/post/3mkzyhe5z4a2v#PureAutonomicFailure carries an annual phenoconversion rate of 5% to central a-synucleinopathies including #ParkinsonDisease, #MSA, and #DLB; subtle motor signs and REM sleep behavior disorder consistently predict conversion risk. ja.ma/49bELVl04 May 2026 15:30 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mkzyhe5z4a2vhttps://bsky.app/profile/jamaneurology.com/post/3mkpo7gzdoe2dAmong patients younger than 55 years, recurrent #Stroke rates declined prior to 2000 but have remained stable since, indicating that further reductions in stroke recurrence may require new preventive strategies. ja.ma/4cMkiHy30 Apr 2026 13:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mkpo7gzdoe2dhttps://bsky.app/profile/jamaneurology.com/post/3mklaow4can2mIn a nationwide cohort, adults with a first-time seizure had a markedly increased risk of both neurological and nonneurological #Cancer within 1 year, with slightly higher long-term risk, supporting broader diagnostic assessment in select patients. ja.ma/3R6zqbC28 Apr 2026 18:47 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mklaow4can2mhttps://bsky.app/profile/jamaneurology.com/post/3mkij2ldmek2tIn cryptogenic new-onset refractory status epilepticus, serum #NeurofilamentLightChain levels indicated greater and faster neuronal injury than in etiology-defined status epilepticus or chronic #Epilepsy. ja.ma/3Qzl4Av27 Apr 2026 16:39 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mkij2ldmek2thttps://bsky.app/profile/jamaneurology.com/post/3mkfpp2duqq2lIn #AlzheimerDisease risk, a high-intensity multidomain lifestyle intervention did not alter brain biomarker trajectories, but older adults with lower baseline hippocampal volume derived greater cognitive benefit from structured intervention. ja.ma/4etg1vt26 Apr 2026 14:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mkfpp2duqq2lhttps://bsky.app/profile/jamaneurology.com/post/3mkffn6t4ky26This case report describes a 73-year-old man with a type B aortic dissection and quadriplegia. ja.ma/4mUjSUm26 Apr 2026 11:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mkffn6t4ky26https://bsky.app/profile/jamaneurology.com/post/3mkcv6bl5nc2vThis case report discusses a patient with vertebral pseudoaneurysm that spontaneously ruptured and led to vertebro-vertebral arteriovenous fistula requiring endovascular therapy. ja.ma/4mUGyE625 Apr 2026 11:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mkcv6bl5nc2vhttps://bsky.app/profile/jamaneurology.com/post/3mk5uahc6vq2lGreater adherence to the #DASH diet, plant-based dietary patterns, or diets with lower hyperinsulinemia and inflammation was associated with lower risk of subjective cognitive decline and better cognitive function in adults. ja.ma/4ttMV3D23 Apr 2026 11:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mk5uahc6vq2lhttps://bsky.app/profile/jamaneurology.com/post/3mk3ntfbezz2mIn an exploratory analysis of the ARCADIA randomized clinical trial, hypertension with high‑risk features was associated with modification of antithrombotic treatment effects after cryptogenic stroke. ja.ma/4u6hD2I22 Apr 2026 14:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mk3ntfbezz2mhttps://bsky.app/profile/jamaneurology.com/post/3mk3hjclolv2mIn preclinical #AlzheimerDisease, women exhibited higher plasma phosphorylated tau 217 at greater amyloid-β burden and faster tau accumulation and cognitive decline compared with men. ja.ma/4n372U122 Apr 2026 12:07 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mk3hjclolv2mhttps://bsky.app/profile/jamaneurology.com/post/3mjze2zpmmc22Among adults with newly diagnosed focal #Epilepsy, suicidality at diagnosis was associated with more than double the risk of future drug resistance vs mood or anxiety disorders alone. ja.ma/4tS5RbS21 Apr 2026 16:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjze2zpmmc22https://bsky.app/profile/jamaneurology.com/post/3mjzapq7q2j2gIn #Stroke due to medium or distal vessel occlusion, endovascular treatment plus best medical treatment preserved more brain tissue and was linked to improved imaging outcomes and better clinical recovery compared with medical treatment alone. ja.ma/4sOrKYO21 Apr 2026 15:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjzapq7q2j2ghttps://bsky.app/profile/jamaneurology.com/post/3mjwtm3rzew23Interview with Susan M. Landau, PhD, author of Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention:The POINTER Imaging Ancillary Study. Hosted by Cynthia E. Armand, MD. ja.ma/4eDthgK20 Apr 2026 16:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjwtm3rzew23https://bsky.app/profile/jamaneurology.com/post/3mjwrwh3ibm2pIn #AlzheimerDisease risk, a high-intensity multidomain lifestyle intervention did not alter brain biomarker trajectories, but older adults with lower baseline hippocampal volume derived greater cognitive benefit from structured intervention. ja.ma/3QmgWnh20 Apr 2026 15:30 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjwrwh3ibm2phttps://bsky.app/profile/jamaneurology.com/post/3mjwlil44ji2oAmong adults with #ChronicSubduralHematoma, long-term survival was lower than in the general population, and survivors experienced persistent cognitive and functional impairments despite preserved global quality of life, even after surgical treatment. ja.ma/3QAHhxX20 Apr 2026 13:34 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjwlil44ji2ohttps://bsky.app/profile/jamaneurology.com/post/3mjwctny6d322Five years of ublituximab treatment in #MultipleSclerosis demonstrated sustained reduction in relapse rates and confirmed disability progression, with safety profile consistent over time. ja.ma/4vK8tdS20 Apr 2026 11:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjwctny6d322https://bsky.app/profile/jamaneurology.com/post/3mjrbvtdjjz2yIn patients with atrial fibrillation and recent stroke, adding catheter ablation to oral anticoagulation did not significantly reduce recurrent stroke, systemic embolism, death, or hospitalization for heart failure compared to standard therapy. ja.ma/4te51q418 Apr 2026 11:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjrbvtdjjz2yhttps://bsky.app/profile/jamaneurology.com/post/3mjmhoklrg22zPrimeC demonstrated comparable safety to placebo and showed slowed functional decline, reduced ALS-related complications, and modulation of iron-regulatory and microRNA biomarkers in adults with #ALS over 18 months of treatment. ja.ma/4lXjuE216 Apr 2026 13:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjmhoklrg22zhttps://bsky.app/profile/jamaneurology.com/post/3mjk2kwpeg62o#CavernousSinus dural arteriovenous fistula can present with proptosis, conjunctival injection, and ophthalmoplegia; endovascular embolization achieved complete occlusion and rapid symptom resolution in this case. ja.ma/3QFU95P15 Apr 2026 14:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjk2kwpeg62ohttps://bsky.app/profile/jamaneurology.com/post/3mjjvjykd4o2bAerobic exercise, intensive blood pressure and cholesterol reduction, or both did not show differences in cognitive function improvement over 24 months among older adults with family history of #dementia or subjective #cognitive decline. ja.ma/4m2irCI15 Apr 2026 12:30 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjjvjykd4o2bhttps://bsky.app/profile/jamaneurology.com/post/3mjhk3zmqsn2i💬Editorial: Decade-long follow-up highlights that patients with surgically treated #ChronicSubduralHematoma have persistent excess mortality and long-term cognitive and functional impairment, even when overall quality of life appears preserved. ja.ma/4sy8heK14 Apr 2026 14:00 +0000at://did:plc:i5h3b76gf3tu5vfp4ehdkcrw/app.bsky.feed.post/3mjhk3zmqsn2i