Neuropsychopharmacology (NPP) is an official peer-reviewed publication of the American College of Neuropsychopharmacology. We report discoveries and promote training & outreach initiatives.https://bsky.app/profile/npp-journal.bsky.socialhttps://bsky.app/profile/npp-journal.bsky.social/post/3mlvpu6cgbk2bThis recent study used a 🐭 model of treatment-resistant depression & RNA sequencing to reveal transcriptional signatures associated with antidepressant treatment & TRD / Angélica Torres-Berrío, PhD @sinaibrain.bsky.social Eric Nestler Eric Parise https://www.nature.com/articles/s41386-026-02366-615 May 2026 16:10 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mlvpu6cgbk2bhttps://bsky.app/profile/npp-journal.bsky.social/post/3mltad3inur2sThis recent review focuses on an evidence-informed stepwise algorithm for approaching precision pharmacotherapy for late-life depression (LLD) 💊 https://www.nature.com/articles/s41386-026-02338-w14 May 2026 16:27 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mltad3inur2shttps://bsky.app/profile/npp-journal.bsky.social/post/3mlqwoxywks2aIn this recent study, an individualized task-guided accelerated continuous theta burst stimulation strategy targeting the right dlPFC shows efficacy in alleviating depressive and anxiety symptoms while improving social dysfunction in MDD https://www.nature.com/articles/s41386-026-02365-713 May 2026 18:29 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mlqwoxywks2ahttps://bsky.app/profile/npp-journal.bsky.social/post/3mlogbnlols2eThis recent study demonstrates that the sodium leak channel NALCN in dopamine D2 receptor-expressing striatal neurons modulates response to anti-dopaminergic treatments in a sex-specific manner https://www.nature.com/articles/s41386-026-02363-912 May 2026 18:30 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mlogbnlols2ehttps://bsky.app/profile/npp-journal.bsky.social/post/3mlnz7r4yzk2xNew drop of #TWiNPP! See below for the latest studies published in NPP👇12 May 2026 14:36 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mlnz7r4yzk2xhttps://bsky.app/profile/npp-journal.bsky.social/post/3mllsi7f6622pThis recent studied leverages machine learning to determine that stress-related neurotoxicity may contribute to cognitive decline in PTSD / Anthony Chesebro https://www.nature.com/articles/s41386-026-02358-611 May 2026 17:31 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mllsi7f6622phttps://bsky.app/profile/npp-journal.bsky.social/post/3mleawhypfy2zIn this recent review, the authors underscore key contributors to heterogeneity in later life and highlight importance of computational psychiatry and implementation science for developing tractable real-world solutions / Olu Ajilore, MD, PhD https://www.nature.com/articles/s41386-026-02342-008 May 2026 17:28 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mleawhypfy2zhttps://bsky.app/profile/npp-journal.bsky.social/post/3mlbiij3zte23This recent study found that that psilocybin microdosing rescues recognition memory deficits, potentially via neurotrophic signaling, in a mouse 🐀 model of Fragile X Syndrome https://www.nature.com/articles/s41386-026-02361-x07 May 2026 15:05 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mlbiij3zte23https://bsky.app/profile/npp-journal.bsky.social/post/3ml7dff445v24This recent study found that adaptive harm avoidance is dependent on a time-sensitive window of GABA-mediated inhibition of VTA dopamine neurons during punishment learning https://www.nature.com/articles/s41386-026-02368-406 May 2026 18:29 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3ml7dff445v24https://bsky.app/profile/npp-journal.bsky.social/post/3ml4zbyyvxc2kWe're back with an all new lineup of what's new #TWiNPP05 May 2026 20:22 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3ml4zbyyvxc2khttps://bsky.app/profile/npp-journal.bsky.social/post/3ml4syto5pp26This recent study explored how exposure to psilocybin during adolescence induces long-term changes in the brain and behavior in a sex-specific manner in 🐭 https://www.nature.com/articles/s41386-026-02356-805 May 2026 18:30 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3ml4syto5pp26https://bsky.app/profile/npp-journal.bsky.social/post/3ml2e5dpv6w2eThis recent study used large-scale phenotyping of rats 🐀 to unveil genetic variants underlying susceptibility to opioid use disorder https://www.nature.com/articles/s41386-026-02348-804 May 2026 18:59 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3ml2e5dpv6w2ehttps://bsky.app/profile/npp-journal.bsky.social/post/3mksj6qoezq2eIn this perspective, the authors emphasize the importance of healthcare delivery science in ensuring successful translation of evidence-based interventions to the clinic https://www.nature.com/articles/s41386-026-02326-001 May 2026 16:08 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mksj6qoezq2ehttps://bsky.app/profile/npp-journal.bsky.social/post/3mkpvexqs2f2zThis diffusion MRI study identified a dorsomedial prefrontal-thalamic pathway underlying harm avoidance in multiple psychiatric disorders https://www.nature.com/articles/s41386-026-02357-730 Apr 2026 15:08 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mkpvexqs2f2zhttps://bsky.app/profile/npp-journal.bsky.social/post/3mknm7rofvc2eThis recent study demonstrated how stereoselective enantiomers of MDMA drive cortical plasticity in a sex-specific manner 🐀 https://www.nature.com/articles/s41386-025-02313-x29 Apr 2026 17:19 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mknm7rofvc2ehttps://bsky.app/profile/npp-journal.bsky.social/post/3mkl7q63jje2sThis recent study used PET imaging to investigate grey matter synaptic terminal density in individuals with schizophrenia https://www.nature.com/articles/s41386-026-02349-728 Apr 2026 18:30 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mkl7q63jje2shttps://bsky.app/profile/npp-journal.bsky.social/post/3mkl5cqhvjk2zWe're back with another round of #TWiNPP and buckle up, because it's a LONG one 🤩 See below for ELEVEN (‼️) of the latest findings from @npp-journal.bsky.social including the newest insights regarding TMS, semaglutide, cannabis, and more 👇28 Apr 2026 17:46 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mkl5cqhvjk2zhttps://bsky.app/profile/npp-journal.bsky.social/post/3mkiqigckhv24This recent study identified immature granule neurons in the hippocampus as a key mediator of the antidepressant effects of electroconvulsive shock therapy ⚡️ https://www.nature.com/articles/s41386-026-02345-x27 Apr 2026 18:52 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mkiqigckhv24https://bsky.app/profile/npp-journal.bsky.social/post/3mkb2j6r3q32zThis recent study investigated hypocretin signaling in early abstinence as a potential therapeutic target in cocaine use disorder 💊 https://www.nature.com/articles/s41386-025-02315-924 Apr 2026 17:30 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mkb2j6r3q32zhttps://bsky.app/profile/npp-journal.bsky.social/post/3mk6grjtn6j2qHow can AI and robotics support—but not replace—mental health of geriatric population? This recent review explores the promise & limitations of computational tools in addressing late-life mental health 🤖🧠 https://www.nature.com/articles/s41386-026-02328-y23 Apr 2026 16:31 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mk6grjtn6j2qhttps://bsky.app/profile/npp-journal.bsky.social/post/3mk3swos2df2mHippocampal perineuronal nets (PNNs) exert a timing-dependent dual role in cognition, balancing plasticity and neuroprotection, with results suggesting PNN–PV interactions as a key regulator of memory and as a potential therapeutic target 🧠💊 https://www.nature.com/articles/s41386-026-02343-z22 Apr 2026 15:31 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mk3swos2df2mhttps://bsky.app/profile/npp-journal.bsky.social/post/3mjzgb6ou6s2tApril showers have brought spring flowers, and by flowers, I mean a beautiful new lineup of NPP articles ready for viewing #ThisWeekInNPP 😍🌻🌷 #TWiNPP21 Apr 2026 16:39 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mjzgb6ou6s2thttps://bsky.app/profile/npp-journal.bsky.social/post/3mjzfrp5c5f23This recent review highlights how late-life bipolar disorder is marked by disproportionate cognitive impairment & medical comorbidity that drive functional decline, underscoring the need for age-adjusted clinical strategies 🧠 https://www.nature.com/articles/s41386-026-02330-421 Apr 2026 16:30 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mjzfrp5c5f23https://bsky.app/profile/npp-journal.bsky.social/post/3mjx5h6lqgq24In a longitudinal study, the authors link cannabis use to blunted reward anticipation signaling, a neural pattern associated with addiction and anhedonia 🧠 / Matt Wall https://www.nature.com/articles/s41386-026-02377-320 Apr 2026 18:54 +0000at://did:plc:ihuhtpw6bbb37om6dynrokc4/app.bsky.feed.post/3mjx5h6lqgq24