Prof @ucsf/immunox, co-founder Solvingfor.org, Immunologist,Immunotherapy pioneer,believer in the power of curiosity,striving to make sense of complicated things, typically enthusiastic.https://bsky.app/profile/maxkrummel.bsky.socialhttps://bsky.app/profile/maxkrummel.bsky.social/post/3me64z33nec2oRegistration is now open and an all-in roster of immunologists anchor the premiere Dendritic cell meeting. https://www.dc2026sandiego.com/invited-speakers Sunny (blue state) San Diego. Sessions devoted to honoring 15 year anniversary of Nobel prize (Steinman) and translational advances…what is not to like.?06 Feb 2026 05:05 +0000at://did:plc:ik2ca43oawwornfwpxruof3f/app.bsky.feed.post/3me64z33nec2ohttps://bsky.app/profile/maxkrummel.bsky.social/post/3lyzuwtmiik2cHow will our increasingly deep understanding of diverse immune archetypes in cancers guide our search for cures? This perspective describes a future in which we discover drugs based on transitions of tissue/immunobiology through intermediate states, to health. https://authors.elsevier.com/a/1llig5TA51lD9X17 Sep 2025 12:53 +0000at://did:plc:ik2ca43oawwornfwpxruof3f/app.bsky.feed.post/3lyzuwtmiik2chttps://bsky.app/profile/maxkrummel.bsky.social/post/3lccazyw5242qMany tx studies (Mujal... Azizi…)failed to validate M1/M2 signatures in vivo. Many also suspected that calling cells bearing ‘prototypical M2’ genes ‘‘immunosuppressive’ was simplistic + incorrect. Nonetheless many (us too!) leaned on the simplification. Arja addresses the reality head on…thnx JEM [contains quote post or other embedded content]02 Dec 2024 04:11 +0000at://did:plc:ik2ca43oawwornfwpxruof3f/app.bsky.feed.post/3lccazyw5242qhttps://bsky.app/profile/maxkrummel.bsky.social/post/3kdkiho5n6j2cAre so-called 'M2-like' CD206+ macrophages immunosuppressive? On the contrary, we find that they are critical for T cell mediated anti-tumor immunity. Arja Ray drove this study with help from Ken Hu, Kelly Kersten, Alexis Combes and others https://www.biorxiv.org/content/10.1101/2023.10.31.560822v106 Nov 2023 22:45 +0000at://did:plc:ik2ca43oawwornfwpxruof3f/app.bsky.feed.post/3kdkiho5n6j2c